(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS 85977-52-2 Ubunyulu ≥99.0% ee≥99.0% Palonosetron Hydrochloride Intermediate Factory
Ubonelelo ngezoRhwebo iPalonosetron Hydrochloride kunye nabaPhakathi abaNxulumeneyo:
(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
I-3-Quinuclidinone Hydrochloride CAS: 1193-65-3
I-1-Naphthoic Acid CAS: 86-55-5
I-Palonosetron Hydrochloride CAS: 135729-62-3 API
Igama leMchiza | (S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid |
Izithethantonye | (1S)-1,2,3,4-Tetrahydronaphthalene-1-Carboxylic acid |
Inombolo yeCAS | 85977-52-2 |
Inombolo yeCAT | RF-CC111 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C11H12O2 |
Ubunzima beMolekyuli | 176.21 |
Ukuxinana | 1.186g/cm3 |
Indawo yokunyibilika | 54.0 ~ 56.0℃ |
Indawo yokubilisa | 342.7 ° C kwi-760 mmHg |
Refractive Index | 1.576 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo weCrystalline oMhlophe okanye ophantse wamhlophe |
Ucoceko lweMichiza | ≥99.0% |
Enantimoer Ukugqithisa | ee ≥99.0% |
Ukungacoceki kwe-Isomer | ≤1.0% |
Ilahleko ekomisweni | ≤0.50% |
Nxulumanisa Into | ≤1.0% |
Ukufuma (KF) | ≤1.0% |
Ukujikeleziswa okuthe ngqo [α]D20 | -59.0°~ -63.0°(C=0.3 kwi-Benzence) |
Iintsimbi ezinzima | ≤20ppm |
Ugcino | 5-8℃ Ukungangeni moya |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Palonosetron Hydrochloride (CAS: 135729-62-3) Abaphakathi |
(S) -1,2,3,4-tetrahydro-1-Naphthoic Acid CAS: 85977-52-2 Indlela ye-Synthesis
Iphakheji: Ibhotile, Igubu lekhadibhodi, 25kg / Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi (S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) kunye nomgangatho ophezulu.Yinto ephakathi ngokuqhelekileyo kwi-synthesis yePalonosetron Hydrochloride (CAS: 135729-62-3).
I-Palonosetron Hydrochloride (i-CAS: i-135729-62-3) i-noveli ye-5-HT3 ye-receptor antagonist eqaliswe njenge-agent ejoyiweyo yokuthintela isicaphucaphu kunye nokulibaziseka kunye nokuhlanza okuhambelana ne-chemotherapy yomhlaza.Inobude obude besiqingatha sobomi (~ 40 h) kunenye ekhoyo ngoku i-5-HT3 antagonists, ebonelela ngeenzuzo ezisebenzayo ekuthinteleni ukulibaziseka kwesicaphucaphu kunye nokuhlanza okwenzeka ngokuqhelekileyo emva kwe-24 h kunye neentsuku ezintandathu emva kokulawulwa kwe-chemotherapy.Nge-1,2,3,4-tetrahydro-1-Naphthoic Acid njengento yokuqala, ukuhlukana, ukuchithwa, ukunciphisa, i-cyclization, ityuwa ye-palonosetron hydrochloride granisetron.
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