(S) -3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Ubunyulu ≥99.0% ee≥99.0% Palonosetron Hydrochloride Intermediate
Ubonelelo ngezoRhwebo iPalonosetron Hydrochloride kunye nabaPhakathi abaNxulumeneyo:
(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
I-3-Quinuclidinone Hydrochloride CAS: 1193-65-3
I-1-Naphthoic Acid CAS: 86-55-5
I-Palonosetron Hydrochloride CAS: 135729-62-3 API
| Igama leMchiza | (S) -3-Aminoquinuclidine Dihydrochloride |
| Izithethantonye | (S)-(-)-3-Aminoquinuclidine 2 HCL |
| Inombolo yeCAS | 119904-90-4 |
| Inombolo yeCAT | RF-CC112 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C7H16Cl2N2 |
| Ubunzima beMolekyuli | 199.12 |
| Ukuxinana | 1.24g/cm3 |
| Indawo yokunyibilika | 260℃ |
| Indawo yokubilisa | 470.4℃ ku-760mmHg |
| Ukunyibilika emanzini | Enyibilikayo |
| Imeko yokuthumela ngenqanawa | Ithunyelwe Ngaphantsi Kweqondo Lobushushu Le-Ambient |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Umgubo weCrystalline oMhlophe ukuya koMthubi |
| IR | ISpectra yokufunxa engqinelana neReferensi |
| I-Chloride Reaction | Ukusabela Okulungileyo |
| Ubunyulu (HPLC) | ≥98.0% |
| Ilahleko ekomisweni | ≤0.50% |
| Ukujikeleziswa okuthe ngqo [α]D20 | -22.0°~ -26.0° (C=1, H2O) |
| Iintsimbi ezinzima | ≤20ppm |
| Ugcino | 5-8℃ Ukungangeni moya |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | I-Palonosetron Hydrochloride (CAS: 135729-62-3) Abaphakathi |
(S)-3-Aminoquinuclidine Dihydrochloride (CAS: 119904-90-4) Indlela yokwenziwa
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, Igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi (S) -3-Aminoquinuclidine Dihydrochloride (CAS: 2133-40-6) kunye nomgangatho ophezulu.I-pharmaceutical intermediate ngokuqhelekileyo kwi-synthesis yePalonosetron Hydrochloride (CAS: 135729-62-3).
I-Palonosetron Hydrochloride (i-CAS: 135729-62-3) iyeza lokuthintela isicaphucaphu kunye nokuhlanza, luhlobo olutsha olukhethiweyo oluphezulu, oluhambelana ne-5-HT3 i-receptor antagonist enokuthintela ukugabha iziko le-reflex peripheral neurons presynaptic 5-HT.I-receptor excitement ichaphazela ngokuthe ngqo inkqubo ye-nervous central kwi-5-HT.I-impulse receptor excitement eyenziwa yindima ye-vagal afferent nerve emva kommandla, ukuvimbela i-vagus nerve endings emathunjini, ukukhusela iimpawu kwi-5-HT.Indawo ye-receptor trigger zone inokunciphisa izehlo zesicaphucaphu kunye nokuhlanza.Embindini weklinikhi kunyango lwe-emetogenic ebukhali kakhulu ichemotherapy ebangela ukulibaziseka kwesicaphucaphu kunye nokugabha.Ngenxa yempembelelo yayo ephezulu yokunyanga, isiphumo esincinci, isiqingatha sobomi obude (malunga ne-40 h), idosi encinci, njalo njalo, iye yatsala ingqalelo enkulu.Nge-1,2,3,4-tetrahydro-1-naphthoic acid njengento yokuqala, ukuhlukana, ukuchithwa, ukunciphisa, i-cyclization, ityuwa ye-palonosetron hydrochloride granisetron.Izifundo zeklinikhi zibonise ukuba i-palonosetron ingasetyenziswa ngokukhuselekileyo kunye ne-corticosteroids, i-analgesics, i-antiemetics, i-antispasmodics kunye ne-anticholinergic drug njengezinto zokuqala, ukwahlukana, ukuchithwa, ukunciphisa, i-cyclization, ityuwa ye-palonosetron hydrochloride granisetron.
