I-Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Purity >99.0% (HPLC) API Factory High Quality

Inkcazelo emfutshane:

Igama leMichiza: iSitagliptin Phosphate Monohydrate

CAS: 654671-77-9

Ubunyulu:> 99.0% (HPLC kwisiseko esomisiweyo)

Imbonakalo: Mhlophe ukuya kuMhlophe-Mhlophe wePowder

Kunyango lwe-II diabetes mellitus

Umgangatho ophezulu we-API, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

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Inkcazo:

Ubonelelo ngeSitagliptin Phosphate Monohydrate Eziyeleleneyo neziPhakathi:
I-Sitagliptin API CAS 486460-32-6
I-Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
I-Sitagliptin Triazole Hydrochloride CAS 762240-92-6
I-Sitagliptin Phosphate Monohydrate ePhakathi CAS 486460-21-3

Iipropati zeMichiza:

Igama leMchiza	ISitagliptin Phosphate Monohydrate
Izithethantonye	(R) -3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4- (2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate
Inombolo yeCAS	654671-77-9
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C16H20F6N5O6P
Ubunzima beMolekyuli	523.3240802
Indawo yokunyibilika	202.0~204.0℃
Ukunyibilika kwamanzi	Inyibilika emanzini
Ukujikeleziswa okuthe ngqo	-18.0°~-23.0° (C=1, Amanzi)
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya kuMhlophe oMhlophe wePowder
Ukuchongwa yi-HPLC	Ixesha lokugcinwa kwesampulu lihambelana nomgangatho wereferensi
I-IR-Infrared Spectrum	I-IR Absorption Spectrum yesampulu iya kuhambelana naleyo ye-spectrum eqhelekileyo
Iphosphate	Iyahambelana
Ubunyulu / Indlela yokuHlalutya	> 99.0% (HPLC kwisiseko esomisiweyo)
Isiqulatho samanzi (KF)	3.3%~4.4%
Intsalela kwi-Ignition	≤0.20%
Isulphate	≤0.02%
I-Chloride	≤0.05%
Ukungacoceki kweChiral	<0.50%
Izinto ezinxulumeneyo
Ukungacoceki Okukodwa	<0.50%
Ukungcola ngokupheleleyo	<1.0%
I-Ethyl Acetate	<0.50%
Iintsimbi ezinzima	<20ppm
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	AbaPhakathi bamayeza

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.

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Isicelo:

I-Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), ichiza elitsha lokunyanga uhlobo lwe-2 yeswekile.Ngo-Agasti ka-2009, ichiza lamkelwa yiManyano yaseYurophu njengechiza lokuqala kunyango lwe-2 seswekile.I-Sitagliptin Phosphate yeyokuqala i-FDA-evunyiweyo yi-dipeptidyl peptidase-IV inhibitor ukuba isetyenziswe kunyango lwe-2 yeswekile ukuza kuthi ga ngoku, phantsi kwegama lezorhwebo elithi Januvia.I-Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) ithoba ngokukhawuleza nangokufanelekileyo i-GLP-1, i-GLP-1, esesona sikhuthazi sisebenzayo sokuvelisa i-insulin kunye nokukhuselwa Ke ngoko, ukuvinjwa kwe-DPP-IV kunokonyusa indima ye-GLP-1 engapheliyo, ngaloo ndlela inyusa igazi. amanqanaba e-insulin, ngaloo ndlela kunciphisa kunye nokugcina amanqanaba eglucose yegazi kwizigulane ezinesifo seswekile.Okwangoku, iyeza liqinisekisile ukuba i-DPP-IV inhibitor luhlobo olutsha lweziyobisi ezichasayo, kwaye iziphumo zeklinikhi zibonisa ukuba iziyobisi zinefuthe elihle le-hypoglycemic.Ngenxa yokuba i-GLP-1 idlala indima exhomekeke kwi-glucose ekukhuthazeni ukuveliswa kwe-insulin kunye nokukhupha, ukusabela okungathandekiyo okuqhelekileyo okufana ne-hypoglycemia kunye nokuzuza ubunzima okubangelwa ukusetyenziswa kweziyobisi ze-antidiabetic akwenzeki.