I-Sodium 4-Aminosalicylate CAS 133-10-8 Ubunyulu > 99.0% (HPLC)

Inkcazelo emfutshane:

Igama leKhemikhali: I-Sodium 4-Aminosalicylate

CAS: 133-10-8

Ubunyulu: >99.0% (HPLC)

Imbonakalo: Umgubo weCrystalline oMhlophe okanye oMhlophe

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Inkcazo:

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Iipropati zeMichiza:

Igama leMchiza I-Sodium 4-Aminosalicylate
Izithethantonye I-4-Amino-Salicylic Acid Ityuwa yeSodium;I-4-Amino-2-Hydroxybenzoic Acid yeTyuwa yeSodium;I-4-Aminosalicylic Acid Ityuwa yeSodium;Isodium p-Aminosalicylate;p-Aminosalicylic Acid Sodium iTyuwa
Inombolo yeCAS 133-10-8
Inombolo yeCAT RF2771
Ubume beStokhwe Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli C7H6NNaO3
Ubunzima beMolekyuli 175.12
Indawo yokunyibilika 265.0~270.0℃
Inovakalelo Hygroscopic
Ukunyibilika Inyibilika ngokulula emanzini, iNyibilika kancinane kwi-Ethanol, ayinyibiliki kwi-acetone
Uphawu Ruifu Chemical

Iinkcukacha:

Into Iinkcukacha
Imbonakalo Umgubo weCrystalline oMhlophe okanye oMhlophe
Ubunyulu / Indlela yokuHlalutya >99.0% (HPLC)
Amanzi (nguKarl Fischer) <2.00%
3-Aminophenol <0.25%
Ukungcola ngokupheleleyo <1.00%
I-Infrared Spectrum Iyahambelana neSakhiwo
Proton NMR Spectrum Iyahambelana neSakhiwo
Umgangatho woVavanyo Umgangatho woShishino
Ukusetyenziswa abaPhakathi bamayeza;Iarhente yeAntitubercular

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Isicelo:

I-sodium 4-Aminosalicylate (i-CAS: 133-10-8) i-soluble ngokulula emanzini, i-soluble kancinane kwi-ethanol, i-insoluble kwi-acetone.Ingasetyenziswa njengamachiza achasene nesifo sephepha, ingakumbi kunyango olubanzi losulelo lwesifo sephepha.Le mveliso ifana ne-4-Aminobenzoic acid (PABA) kwisakhiwo, i-congener ye-PABA.Ithintela ukukhula kunye nokuveliswa kwesifo sephepha seMycobacterium ngokuthintela ukhuphiswano lwe-folate synthesis.Le mveliso isebenza kuphela kwi-mycobacteria, kungekhona i-mycobacteria ye-atypical.Xa isetyenziswa yodwa, inokukhula ngokukhawuleza ukunganyangeki kumachiza.Le mveliso kufuneka idityaniswe namanye amachiza okulwa nesifo sephepha, anjengestreptomycin kunye ne-isoniazid, ezinokulibazisa ukuveliswa kokumelana namachiza kwi-bacilli yesifo sephepha ukuya kwezi zibini zokugqibela.Ngokonyango, isetyenziselwa ikakhulu isifo sephepha semiphunga kunye nesangaphandle kwemiphunga esibangelwa sisifo sephepha iMycobacterium.Ikwasetyenziswa kwi-hyperthyroidism kwaye inefuthe elinamandla ekunciphiseni i-lipids yegazi.Ifakwe kakuhle kwiphecana le-GI.Ifunxwa ngokukhawuleza ngakumbi kunezinye i-salicylic acids.Emva kokufunxwa, isasazwa ngokukhawuleza kulwelo olwahlukeneyo lomzimba kwaye ifikelela kugxininiso oluphezulu kakhulu kulwelo lwe-pleural, kodwa ugxininiso kulwelo lwe-cerebrospinal luphantsi kakhulu.Imveliso isasazeka ngokukhawuleza kwizintso, imiphunga kunye nezicubu zesibindi, ifikelela kwiindawo eziphezulu kwii-caseous tissues.Ifanelekile kwi-pulmonary and extrapulmonary tuberculosis ebangelwa yi-Mycobacterium tuberculosis.I-sodium para-aminosalicylate iyasebenza kuphela ngokuchasene ne-mycobacteria kwaye hayi ngokuchasene ne-mycobacteria engekhoyo.Ukunganyangeki kungakhula ngokukhawuleza xa isetyenziswa yodwa, ngoko ke kufuneka idityaniswe namanye amachiza alwa ne-TB.I-Streptomycin kunye ne-isoniazid, xa zidityanisiwe nazo, zinokulibazisa ukukhula kokunganyangeki ngamachiza kwe-Mycobacterium tuberculosis kula machiza mabini.Isetyenziswa kakhulu njengechiza elichasene nesifo sephepha kumgca wesibini.Ingasetyenziselwa i-hyperthyroidism, kwaye ifanelekile kwizigulana ezine-hyperthyroidism kunye nesifo sephepha.Xa i-agent ye-iodine ingasebenzi kwaye ichaphazela ukusebenza, inokuthatyathwa ixesha elifutshane ukudala iimeko zokusebenza.Ukufakwa kwi-intravenous ngokuqhelekileyo kusetyenziswa kwiimeko ezinzima ezifana ne-tuberculous meningitis.

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