Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity

Inkcazelo emfutshane:

Igama leKhemikhali: Tacrolimus

Izithethantonye: FK-506;Fujimycin

CAS: 104987-11-3

Imbonakalo: Umgubo oMhlophe oMhlophe okanye oMthubi oLungileyo, ongenavumba, iNcasa eSwiti ekhethekileyo

Uvavanyo: ≥72.0% (HPLC, kwisiseko esomileyo)

I-API, uMgangatho oPhezulu, iMveliso yoRhwebo

E-mail: alvin@ruifuchem.com

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Inkcazo:

Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Tacrolimus
Izithethantonye: FK-506;Fujimycin
CAS: 104987-11-3
I-API, uMgangatho oPhezulu, iMveliso yoRhwebo

Iipropati zeMichiza:

Igama leMchiza	Tacrolimus
Izithethantonye	FK-506;Fujimycin
Inombolo yeCAS	104987-11-3
Inombolo yeCAT	RF-API46
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	C44H69NO12
Ubunzima beMolekyuli	804.02
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe oMhlophe okanye oMthubi oLungileyo, ongenavumba, iNcasa eSwiti ekhethekileyo
Ukuchongwa	Kufuneka kube Ukusabela Okulungileyo
Ukucaca	Thobela uMgangatho
pH	5.0~6.0
I-Chloride	≤0.014%
Isulphate	≤0.029%
Iintsimbi ezinzima (Pb)	≤10ppm
Arsenic	≤0.0002%
Ukufuma (KF)	≤8.0%
Intsalela kwi-Ignition	18.0%~22.0%
Isivavanyi	≥72.0% (HPLC, kwisiseko esomileyo)
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Tacrolimus (kwaye i-FK-506 okanye i-Fujimycin) ichiza le-immunosuppressive elisetyenziswa kakhulu emva kokutshintshwa kwelungu lokunciphisa umsebenzi we-immune system yesigulane kwaye ngoko ke umngcipheko wokulahlwa kwamalungu.Ikwasetyenziswa kulungiselelo lwezihloko kunyango lwe-atopic dermatitis ebukhali, uveitis enqabileyo enqabileyo emva kokutshintshwa komongo wethambo, kunye nemeko yesikhumba i-vitiligo.I-Tacrolimus yaqala ukutsalwa kumhluzi wokubilisa we-Streptomyces tssukuba, intsholongwane yomhlaba efumaneka eTsukuba, eJapan.Igama elithi tacrolimus lithatyathwe ngokuthatha i-'t' ye-Tsukuba, igama lentaba apho isampuli yomhlaba yakhutshwa khona, 'acrol' ye-macrolide kunye ne-'imus' ye-immunosuppressant.Nangona i-structural ingahambelani ne-cyclosporin, i-tacrolimus ibonisa i-spectrum efanayo yemiphumo ye-immunosuppressive kule arhente kwinqanaba leselula kunye ne-molecular.Uphononongo lokuqala lubonise ukuba i-tacrolimus yayiyi-immunosuppressant enamandla, ibonisa malunga ne-100-fold in vitro potency enkulu kune-cyclosporin ekuvimbeleni ukusebenza kwe-T cell.Uphononongo olulandelayo lwe-vivo lubonise i-tacrolimus ukuba isebenze kokubini ekucinezeleni isifo esizenzekelayo kunye novavanyo lwe-autoimmune, kunye nokuthintela i-allograft kunye nokwaliwa kwe-xenograft kwiimodeli zezilwanyana zokufakelwa kwamalungu.Ekuqaleni, i-tacrolimus yayisetyenziselwa i-systemic immunosuppression yezigulana eziye zenziwa uqhaqho-fakelo lwe-allograft ukubanqanda ekwaleni ukufakelwa kwabo okutsha.Kungekudala, nangona kunjalo, ngenxa yenzuzo ye-serendipity yesayensi, kwaphawulwa ukuba i-tacrolimus inokuvelisa iziphumo ezilungileyo kukuphazamiseka kwesikhumba kwezinye izigulana eziye zatshintshwa.Ukufunyaniswa kwe-tacrolimus kukhokelela ekuqondeni ngakumbi i-pathology yesikhumba, umzekelo we-atopic dermatitis.Emva koko, ezinye izicelo ze-tacrolimus zaxelwa kwaye ukusetyenziswa kwale arhente kwidermatology kukhula ngokuthe ngcembe.