Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity
Umenzi onobunyulu obuPhezulu kunye noMgangatho oZinzile
Igama leKhemikhali: Tacrolimus
Izithethantonye: FK-506;Fujimycin
CAS: 104987-11-3
I-API, uMgangatho oPhezulu, iMveliso yoRhwebo
Igama leMchiza | Tacrolimus |
Izithethantonye | FK-506;Fujimycin |
Inombolo yeCAS | 104987-11-3 |
Inombolo yeCAT | RF-API46 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | C44H69NO12 |
Ubunzima beMolekyuli | 804.02 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe oMhlophe okanye oMthubi oLungileyo, ongenavumba, iNcasa eSwiti ekhethekileyo |
Ukuchongwa | Kufuneka kube Ukusabela Okulungileyo |
Ukucaca | Thobela uMgangatho |
pH | 5.0~6.0 |
I-Chloride | ≤0.014% |
Isulphate | ≤0.029% |
Iintsimbi ezinzima (Pb) | ≤10ppm |
Arsenic | ≤0.0002% |
Ukufuma (KF) | ≤8.0% |
Intsalela kwi-Ignition | 18.0%~22.0% |
Isivavanyi | ≥72.0% (HPLC, kwisiseko esomileyo) |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | API |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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I-Tacrolimus (kwaye i-FK-506 okanye i-Fujimycin) ichiza le-immunosuppressive elisetyenziswa kakhulu emva kokutshintshwa kwelungu lokunciphisa umsebenzi we-immune system yesigulane kwaye ngoko ke umngcipheko wokulahlwa kwamalungu.Ikwasetyenziswa kulungiselelo lwezihloko kunyango lwe-atopic dermatitis ebukhali, uveitis enqabileyo enqabileyo emva kokutshintshwa komongo wethambo, kunye nemeko yesikhumba i-vitiligo.I-Tacrolimus yaqala ukutsalwa kumhluzi wokubilisa we-Streptomyces tssukuba, intsholongwane yomhlaba efumaneka eTsukuba, eJapan.Igama elithi tacrolimus lithatyathwe ngokuthatha i-'t' ye-Tsukuba, igama lentaba apho isampuli yomhlaba yakhutshwa khona, 'acrol' ye-macrolide kunye ne-'imus' ye-immunosuppressant.Nangona i-structural ingahambelani ne-cyclosporin, i-tacrolimus ibonisa i-spectrum efanayo yemiphumo ye-immunosuppressive kule arhente kwinqanaba leselula kunye ne-molecular.Uphononongo lokuqala lubonise ukuba i-tacrolimus yayiyi-immunosuppressant enamandla, ibonisa malunga ne-100-fold in vitro potency enkulu kune-cyclosporin ekuvimbeleni ukusebenza kwe-T cell.Uphononongo olulandelayo lwe-vivo lubonise i-tacrolimus ukuba isebenze kokubini ekucinezeleni isifo esizenzekelayo kunye novavanyo lwe-autoimmune, kunye nokuthintela i-allograft kunye nokwaliwa kwe-xenograft kwiimodeli zezilwanyana zokufakelwa kwamalungu.Ekuqaleni, i-tacrolimus yayisetyenziselwa i-systemic immunosuppression yezigulana eziye zenziwa uqhaqho-fakelo lwe-allograft ukubanqanda ekwaleni ukufakelwa kwabo okutsha.Kungekudala, nangona kunjalo, ngenxa yenzuzo ye-serendipity yesayensi, kwaphawulwa ukuba i-tacrolimus inokuvelisa iziphumo ezilungileyo kukuphazamiseka kwesikhumba kwezinye izigulana eziye zatshintshwa.Ukufunyaniswa kwe-tacrolimus kukhokelela ekuqondeni ngakumbi i-pathology yesikhumba, umzekelo we-atopic dermatitis.Emva koko, ezinye izicelo ze-tacrolimus zaxelwa kwaye ukusetyenziswa kwale arhente kwidermatology kukhula ngokuthe ngcembe.
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