Temozolomide (TMZ) CAS 85622-93-1 Assay 99.0% ~ 101.0% API Factory High Purity
Ukubonelela ngeTemozolomide kunye neMidiya eNxulumeneyo:
I-Temozolomide CAS: 85622-93-1
4 (5)-Amino-5 (4)-Imidazolecarboxamide CAS: 360-97-4
5 (4)-Amino-4 (5)-Imidazolecarboxamide Hydrochloride CAS: 72-40-2
Igama leMchiza | Temozolomide |
Izithethantonye | 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-Carboxamide |
Inombolo yeCAS | 85622-93-1 |
Inombolo yeCAT | RF-API29 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C6H6N6O2 |
Ubunzima beMolekyuli | 194.15 |
Indawo yokunyibilika | NgoDisemba 212 ℃ |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Umgubo oMhlophe ukuya kokuKhanya oPinki |
Ukuchongwa | Ngo-IR, HPLC |
Izinyibilikisi ezishiyekileyo | I-Dimethyl Sulphoxide ≤0.50% |
Izinto ezinxulumeneyo | |
Ukungacoceki kwe-AIC | ≤0.10% |
Ukungacoceki Okukodwa | ≤0.10% |
Phumla ukungcola okungaziwayo | ≤0.30% |
Ukungcola ngokupheleleyo | ≤0.30% |
Iintsimbi ezinzima | ≤10ppm |
Ilahleko ekomisweni | ≤0.50% |
Intsalela kwi-Ignition | ≤0.10% |
Isivavanyi | 99.0% ~ 101.0% (HPLC kwisiseko esomisiweyo) |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | I-Active Pharmaceutical ingredient (API) |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.
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I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili kunye nomthengisi weTemozolomide (CAS: 85622-93-1) kunye nomgangatho ophezulu.I-Temozolomide (TMZ) yi-agent yomlomo ye-alkylating esetyenziselwa ukuphatha i-Glioblastoma Multiforme (GBM) kunye ne-Astrocytomas, i-Metastatic Melanoma.
I-Temozolomide yinto yokuqala esebenzayo yomlomo-i-imidazole kunye ne-tetrazine-class ye-antiticancer ye-antiticancer yesizukulwana sesibini se-alkylating agent kunye nomsebenzi we-antitumor ngaphandle kokusebenza kwesibindi se-metabolic emva kokulawulwa komlomo.Ibonakala ngokungena lula ngomqobo wegazi-ingqondo, ukunyamezelana kakuhle kunye nokungabekwa phezulu kunye nezinye iziyobisi ezinobungozi, kunye nokuba nefuthe le-synergistic kunye ne-radiotherapy efanelekile ukunyanga ukuphindaphinda kwe-glioma enobungozi emva konyango oluqhelekileyo olufana ne-glioblastoma multiforme tumors okanye i-astrocytoma ewohlokayo.Lichiza lokuqala lonyango lwe-metastatic melanoma.
I-Temozolomide yayiye yaqulunqwa okokuqala yiCancer Research UK Group, kwaye emva koko idluliselwe kwiNkampani yeSchering-Plough (eUnited States) ukuze iphuhliswe.Inoveli yesakhiwo sekhemikhali kwaye iphuma kwi-4-imidazole derivative.Ngo-1999, kuye kwavunywa ukuba kungenwe kwimarike e-EU nase-US apho isalathiso esivunyelweyo e-United States ikakhulu sodidi lwesibini lonyango lwe-glioblastoma multiforme kunye ne-degenerative star gliomas kunye neempawu ezivunyiweyo ze-EU kunyango oluphuhlayo okanye olubuyisela umva i-glioblastoma multiforme. esele iphantsi konyango oluqhelekileyo.Ukusebenza kwe-temozolomide ekunyangeni i-glioblastoma multiforme kuye kwaqatshelwa ngakumbi eYurophu.