I-Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV High Quality

Inkcazelo emfutshane:

Igama: Tenofovir Alafenamide Hemifumarate (TAF)

I-CAS: 1392275-56-7

Mhlophe ukuya Phantse iiCrystals eziMhlophe okanye umgubo weCrystalline

Uvavanyo: 98.0% ~ 102.0%

Imveliso ye-Tenofovir, esetyenziswa kunyango oludityanisiweyo kunyango lwe-HIV-1

Umgangatho ophezulu, iMveliso yoRhwebo

Inquiry: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo lwe-Tenofovir oluNxulumene naMaphakathi:
I-Tenofovir CAS: 147127-20-6
I-Tenofovir Disoproxil Fumarate CAS 202138-50-9
I-Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
I-Chloromethyl Isopropyl Carbonate CAS 35180-01-9
I-Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
I-Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5

Iipropati zeMichiza:

Igama leMchiza	I-Tenofovir Alafenamide Hemifumarate
Izithethantonye	TAF;GS-7340 Hemifumarate
Inombolo yeCAS	1392275-56-7
Inombolo yeCAT	RF-API91
Ubume beStokhwe	Kwi-Stock, iMveliso yeMveliso ukuya kumakhulu eeKilogram
Ifomula yeemolekyuli	I-C25H33N6O9P
Ubunzima beMolekyuli	592.55
Ubushushu boGcino	Itywinwe kwindawo eyomileyo, ubushushu beGumbi
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Mhlophe ukuya Phantse iiCrystals eziMhlophe okanye umgubo weCrystalline
Ukunyibilika	I-Soluble kwi-Dimethylformamide, kunye ne-Methanol;Inyibilika kancinane emanzini nakwi-THF;Inyibilika kancinane kwiAcetonitrile kwaye ayinyibiliki kwiDichloromethane kunye neToluene
Isazisi A	I-IR yokufunxa i-spectra kufuneka ihambelane nereferensi
Isazisi B	Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu kwichromatogram yokuzimisela komxholo ihambelana naleyo yesisombululo sereferensi.
Isazisi C	Ixesha lokugcinwa kwe-Fumaric Acid lencopho enkulu kwichromatogram yokuzimisela komxholo ihambelana nencopho yereferensi.
Isiqulatho samanzi (nge-KF)	≤1.0%
Ukucaca kwesisombululo	Ngokwenene akukho zincinci ezibonakalayo kwi-2% (w / v) ye-Methanol Solution yokucacisa
Intsalela yokunyibilika
Acetonitrile	≤410ppm
I-Ethanol	≤5000ppm
Dichloromethane	≤600ppm
Toluene	≤890ppm
Intsalela kwi-Ignition	≤0.10%
Iintsimbi ezinzima	≤20ppm
Izinto ezinxulumeneyo
PMPA	≤1.0%
PMPA Anhydride	≤0.75%
Phenyl PMPA eyodwa	≤1.0%
Nakuphi na Ukungcola Okungachazwanga	≤0.15%
Ukungcola ngokupheleleyo	≤2.0%
Isomer	≤1.0%
Umxholo weFumaric Acid	9.0% ~ 13.0% (kwisiseko se-anhydrous)
Imida yeMicrobial
Ubalo olupheleleyo lweAerobic Microbial	≤1000CFU/g
I-Yeasts iyonke kunye ne-Molds Bala	≤100CFU/g
Escherichia Coli	Ukungabikho
Isivavanyi	98.0% ~ 102.0% (kwisiseko se-anhydrous kunye ne-solvent-free basis)
Umgangatho woVavanyo	Umgangatho woShishino

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, igubu lekhadibhodi, 25kg/Igubu, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ekukhanyeni, ukufuma kunye nokuhlaselwa zizinambuzane.

Izinto eziluncedo:

FAQ:

Isicelo:

I-Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, yi-nucleotide reverse transcriptase inhibitor (NRTIs) kunye neprodrug yenoveli yeTenofovir (TFV).Ngokuthintela i-reverse transcriptase, i-TAF ithintela i-HIV ekubeni iziphindaphinde kwaye inokwehlisa umthamo we-HIV emzimbeni.I-Tenofovir alafenamide liyeza, nto leyo ethetha ukuba lichiza elingasebenziyo.Emzimbeni, i-tenofovir alafenamide iguqulelwa ekubeni yi-Tenofovir diphosphate (TFV-DP).I-Tenofovir Alafenamide Fumarate yamkelwa ngoNovemba ka-2015 kunyango lwe-HIV-1.