Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0%~102.0% API Factory

Inkcazelo emfutshane:

Igama leMichiza: Tenofovir Disoproxil Fumarate

CAS: 202138-50-9

Imbonakalo: Umgubo oMhlophe okanye ophantse wamhlophe

Uvavanyo: 98.0% ~ 102.0% (kwisiseko se-anhydrous)

I-nucleotide reverse transcriptase inhibitor esetyenziselwa ukunyanga i-HIV kunye ne-Chronic Hepatitis B.

Umgangatho ophezulu, iMveliso yoRhwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

Ubonelelo ngezoRhwebo lwe-Tenofovir oluNxulumene naMaphakathi:
I-Tenofovir CAS: 147127-20-6
I-Tenofovir Disoproxil Fumarate CAS 202138-50-9
I-Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
I-Chloromethyl Isopropyl Carbonate CAS 35180-01-9
I-Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
I-Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5

Iipropati zeMichiza:

Igama leMchiza	I-Tenofovir Disoproxil Fumarate
Izithethantonye	I-Tenofovir DF;I-Bis(POC)-PMPA Fumarate;GS 4331 Fumarate
Inombolo yeCAS	202138-50-9
Inombolo yeCAT	RF-API106
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C23H34N5O14P
Ubunzima beMolekyuli	635.52
Indawo yokunyibilika	113.0 ukuba 115.0℃
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	Umgubo oMhlophe okanye ophantse wamhlophe
Isazisi A	I-IR Spectrum ihambelana noMgangatho weReferensi
Isazisi B	Ixesha lokugcinwa kwencopho enkulu kwisisombululo sesampulu sihambelana neso sisombululo siqhelekileyo, njengoko sifunyenwe kuvavanyo.
Isivavanyi	98.0% ~ 102.0% (kwisiseko se-anhydrous)
Amanzi	≤1.0%
I-Fumaric Acid	17.5%~19.0%
Intsalela kwi-Ignition	≤0.20%
Iintsimbi ezinzima	≤20ppm
I-Chloromethyl Isopropyl Carbonate	≤0.15%
Izinto ezinxulumeneyo
I-Tenofovir	≤0.15%
Adenine	≤0.15%
I-Tenofovir Isoproxi Monoester	≤1.0%
Tenofovir Disoproxil Ethyl Ester	≤0.15%
I-Tenofovir Isopropyl Isoproxil	≤0.30%
I-Tenofovir Disoproxil Carbamate	≤0.15%
I-Tenofovir Disproxil	≤0.15%
Nakuphi na Ukungacoceki Okukodwa	≤0.10%
Ukungcola ngokupheleleyo	≤2.0%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	API

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma.

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Isicelo:

I-Tenofovir Disoproxil Fumarate (CAS: 202138-50-9), iprodrug ye-tenofovir (Igama loRhwebo: Viread) ephuhliswe yi-Gilead Sciences, luhlobo lwamachiza e-antiretroviral e-nucleotide-analogues, asebenza ngokusebenza njenge-reverse transcriptase inhibitors[nRTIs] , evimba i-reverse transcriptase, i-enzyme ebalulekileyo kwimveliso yentsholongwane kubantu abane-HIV.Kufuneka kuqatshelwe ukuba yi-nucleotide reverse transcriptase inhibitor yokuqala eye yasetyenziselwa unyango losulelo lwe-HIV.I-Tenofovir Disoproxil Fumarate iguqulelwa ekubeni yi-tenofovir kwi-vivo, eyi-acyclic nucleoside phosphonate[nucleotide] analog ye-adenosine 5'-monophosphate.Isetyenziswa ngokubanzi ngokudityaniswa nezinye iintlobo zamayeza.Amayeza e-HIV akanakunyanga i-HIV/AIDS, kodwa ukuthatha indibaniselwano yamayeza e-HIV [abizwa ngokuba yirejimeni ye-HIV] yonke imihla kunokunceda abantu abane-HIV baphile ubomi obude, obunempilo.Ngokusekwe kuxwebhu lwe-FDA, i-tenofovir disoproxil fumarate inokuba yeyonyango lwentsholongwane ye-hepatitis B engapheliyo [HBV] kubantu abadala nakubantwana abaneminyaka eyi-12 nangaphezulu.