tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7 Ubunyulu >98.0% (HPLC) Palbociclib Intermediate Factory Featured Image

tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7 Ucoceko >98.0% (HPLC) Palbociclib Intermediate Factory

Inkcazelo emfutshane:

Igama leMchiza: tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate

Izithethantonye: 1-Boc-4-(6-Nitro-3-Pyridyl)piperazine

CAS: 571189-16-7

Ubunyulu: >98.0% (HPLC)

Imbonakalo: I-Brown ekhanyayo ukuya kwi-Brown Powder

Umbindi wePalbociclib (CAS: 571190-30-2)

E-Mail: alvin@ruifuchem.com

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Iinkcukacha zeMveliso

Iimveliso ezinxulumeneyo

Iithegi zeMveliso

Inkcazo:

I-Ruifu Chemical Supply Palbociclib Related Intermediates:
Palbociclib CAS 571190-30-2
5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5
I-5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8
tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7
tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5
6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7 (8H)-enye CAS 1016636-76-2
I-2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pyrimidin-7-enye CAS 1013916-37-4

Iipropati zeMichiza:

Igama leMchiza	tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate
Izithethantonye	1-Boc-4-(6-Nitro-3-Pyridyl)piperazine;I-4-(6-Nitro-3-pyridinyl) -1-Piperazinecarboxylic Acid tert-Butyl Ester;tert-Butyl 4-(6-Nitro-3-Pyridinyl)-1-Piperazinecarboxylate
Inombolo yeCAS	571189-16-7
Inombolo yeCAT	RF-PI1850
Ubume beStokhwe	Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni
Ifomula yeemolekyuli	I-C14H20N4O4
Ubunzima beMolekyuli	308.33
Uphawu	Ruifu Chemical

Iinkcukacha:

Into	Iinkcukacha
Imbonakalo	I-Brown eKhanya ukuya kwi-Brown Powder
Ubunyulu / Indlela yokuHlalutya	>98.0% (HPLC)
I-LCMS	Ukungqinelana Nolwakhiwo
Ilahleko ekomisweni	<1.00%
Ukungcola ngokupheleleyo	<2.00%
Umgangatho woVavanyo	Umgangatho woShishino
Ukusetyenziswa	Umbindi wePalbociclib (CAS: 571190-30-2)

Ukupakishwa kunye noGcino:

Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi

Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma

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Isicelo:

tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate (CAS: 571189-16-7) iphakathi kwePalbociclib (CAS: 571190-30-2).I-Palbociclib (ekwaziwa ngokuba yi-compound number PD-0332991) lichiza lovavanyo lonyango lomhlaza wamabele eliphuhliswa yiPfizer.Yi-inhibitor ekhethiweyo ye-cyclin-dependent kinases CDK4 kunye ne-CDK6.I-Palbociclib ivimba ukuqhubela phambili komjikelo weseli ukusuka kwisigaba se-G1 ukuya kwi-S ngokuthintela i-CDK4/6-exhomekeke kwi-retinoblastoma (RB) phosphorylation.I-Palbociclibhas isetyenziselwe unyango lwe-HER2 negative, i-estrogen receptor (ER) yomhlaza webele we-metastatic.