Tolvaptan CAS 150683-30-0 API Ucoceko >99.0% (HPLC)
Ubonelelo loMvelisi iTolvaptan kunye neMidiya eNxulumeneyo:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
I-4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
| Igama | eTolvaptan |
| Igama leMchiza | N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide |
| Inombolo yeCAS | 150683-30-0 |
| Inombolo yeCAT | RF-API101 |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
| Ifomula yeemolekyuli | I-C26H25ClN2O3 |
| Ubunzima beMolekyuli | 448.94 |
| Uphawu | Ruifu Chemical |
| Into | Iinkcukacha |
| Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
| Iindlela zokuchongwa | IR, HPLC |
| Ukunyibilika | Inyibilika kwi-Benzyl yoTywala kunye neMethanol kodwa ayinakunyibilika kuManzi kunye neHexane |
| Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
| Indawo yokunyibilika | 219.0 ~ 222.0℃ |
| Ilahleko ekomisweni | <0.50% |
| Intsalela kwi-Ignition | <0.10% |
| Ukungacoceki Okukodwa | <0.50% |
| Ukungcola ngokupheleleyo | <1.00% |
| Iintsimbi ezinzima | ≤20ppm |
| Izinyibilikisi ezishiyekileyo | Hlangana neNkcazo |
| Umgangatho woVavanyo | Umgangatho woShishino |
| Ukusetyenziswa | API;AbaPhakathi bamayeza |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
I-Tolvaptan (i-CAS: i-150683-30-0), eyaziwa ngokuba yi-OPC-41061, i-arginine ekhuphisanayo ye-arginine vasopressin receptor 2 antagonist esetyenziselwa ukunyanga i-hyponatremia (izinga eliphantsi le-sodium yegazi) ehambelana nokungaphumeleli kwentliziyo, i-cirrhosis, kunye nesifo se-syndrome. ihomoni ye-antidiuretic engafanelekanga (SIADH).I-Otsuka Pharmaceutical ilayisensi ye-tolvaptan phantsi kwegama lorhwebo i-Samsca emva kokuba i-FDA ivume ichiza ngoMeyi ka-2009.Kulingo lwe-2004, i-tolvaptan elawulwa nge-diuretics yendabuko yaphawulwa ukuba yandise ukukhutshwa kwamanzi amaninzi kunye nokuphucula amanqanaba e-sodium yegazi kwizigulane ezinentliziyo engaphumeleliyo ngaphandle kokuvelisa iziphumo ezinobungozi ezifana ne-hypotension (uxinzelelo lwegazi oluphantsi) okanye i-hypokalemia (ukunciphisa amanqanaba egazi e-potassium).Ichiza kwakhona alibonisi ziphumo zibi ekusebenzeni kwezintso.
![7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3 Tolvaptan Intermediate](https://www.ruifuchemical.com/uploads/7-Chloro-1234-tetrahydrobenzobazepin-5-one-CAS-160129-45-3-300x300.jpg)
