Tolvaptan CAS 150683-30-0 API Ucoceko >99.0% (HPLC)
Ubonelelo loMvelisi iTolvaptan kunye neMidiya eNxulumeneyo:
Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-enye CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
I-4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
Igama | eTolvaptan |
Igama leMchiza | N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide |
Inombolo yeCAS | 150683-30-0 |
Inombolo yeCAT | RF-API101 |
Ubume beStokhwe | Kwi-Stock, iMveliso yoMveliso ukuya kwiiToni |
Ifomula yeemolekyuli | I-C26H25ClN2O3 |
Ubunzima beMolekyuli | 448.94 |
Uphawu | Ruifu Chemical |
Into | Iinkcukacha |
Imbonakalo | Mhlophe ukuya kuMhlophe oMhlophe wePowder |
Iindlela zokuchongwa | IR, HPLC |
Ukunyibilika | Inyibilika kwi-Benzyl yoTywala kunye neMethanol kodwa ayinakunyibilika kuManzi kunye neHexane |
Ubunyulu / Indlela yokuHlalutya | >99.0% (HPLC) |
Indawo yokunyibilika | 219.0 ~ 222.0℃ |
Ilahleko ekomisweni | <0.50% |
Intsalela kwi-Ignition | <0.10% |
Ukungacoceki Okukodwa | <0.50% |
Ukungcola ngokupheleleyo | <1.00% |
Iintsimbi ezinzima | ≤20ppm |
Izinyibilikisi ezishiyekileyo | Hlangana neNkcazo |
Umgangatho woVavanyo | Umgangatho woShishino |
Ukusetyenziswa | API;AbaPhakathi bamayeza |
Iphakheji: Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi
Imeko yoGcino:Gcina kwizikhongozeli ezivaliweyo kwindawo epholileyo neyomileyo;Khusela ukukhanya kunye nokufuma
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I-Tolvaptan (i-CAS: i-150683-30-0), eyaziwa ngokuba yi-OPC-41061, i-arginine ekhuphisanayo ye-arginine vasopressin receptor 2 antagonist esetyenziselwa ukunyanga i-hyponatremia (izinga eliphantsi le-sodium yegazi) ehambelana nokungaphumeleli kwentliziyo, i-cirrhosis, kunye nesifo se-syndrome. ihomoni ye-antidiuretic engafanelekanga (SIADH).I-Otsuka Pharmaceutical ilayisensi ye-tolvaptan phantsi kwegama lorhwebo i-Samsca emva kokuba i-FDA ivume ichiza ngoMeyi ka-2009.Kulingo lwe-2004, i-tolvaptan elawulwa nge-diuretics yendabuko yaphawulwa ukuba yandise ukukhutshwa kwamanzi amaninzi kunye nokuphucula amanqanaba e-sodium yegazi kwizigulane ezinentliziyo engaphumeleliyo ngaphandle kokuvelisa iziphumo ezinobungozi ezifana ne-hypotension (uxinzelelo lwegazi oluphantsi) okanye i-hypokalemia (ukunciphisa amanqanaba egazi e-potassium).Ichiza kwakhona alibonisi ziphumo zibi ekusebenzeni kwezintso.