Tranexamic Acid CAS 1197-18-8 Assay 99.0~101.0% (Titration)
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili weTranexamic Acid (CAS: 1197-18-8) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iTranexamic Acid,Please contact: alvin@ruifuchem.com
| Igama leMchiza | Tranexamic Acid |
| Izithethantonye | i-trans-4-(Aminomethyl) i-cyclohexanecarboxylic Acid;Trans-Tranexamic Acid;TAMCHA;I-AMCHA;HAKU;I-AMCA;t-AMCHA;trans-Amcha |
| Ubume beStokhwe | Kwi-Stock, iMveliso yoRhwebo |
| Inombolo yeCAS | 1197-18-8 |
| Ifomula yeemolekyuli | C8H15NO2 |
| Ubunzima beMolekyuli | 157.21 g/mol |
| Indawo yokunyibilika | >300℃(lit.) |
| Uzinzo | Hygroscopic |
| Ukunyibilika kwamanzi | Inyibilika Emanzini, Phantse Ukungafihli |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Isampuli yasimahla | Iyafumaneka |
| Imvelaphi | Shanghai, China |
| Uphawu | Ruifu Chemical |
| Izinto | Iinkcukacha | Iziphumo |
| Imbonakalo | Umgubo weCrystalline oMhlophe | Iyahambelana |
| Ukunyibilika | Inyibilika kuManzi kunye neGlacial Acetic Acid, Phantse Ayinyibiliki kwiEthanol kunye neAcetone (96%) | Iyahambelana |
| IR Spectrum | Ngokuhambelana neTranexamic Acid CRS | Iyahambelana |
| pH | 7.0~8.0 | 7.32 |
| Ilahleko ekomisweni | <0.50% | 0.06% |
| I-Sulfate Ash | <0.10% | 0.02% |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| Ikloridi (Cl) | ≤140ppm | <140ppm |
| IArsenic (As) | ≤2ppm | <2ppm |
| Isivavanyi | 99.0 ~ 101.0% (ngeTitration) | 99.84% |
| Izinto ezinxulumeneyo | ||
| Ukungcola A | <0.10% | 0% |
| Ukungcola B | <0.20% | 0.0815% |
| Ukungcola C | <0.10% | 0.0089% |
| Ukungcola D | <0.10% | 0.0063% |
| Ukungcola ngokupheleleyo | <0.20% (Ngaphandle kwe-A,B) | 0.015% |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye ihambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile eFluorinated, iAluminium foil bag, 25kg/Cardboard Drum, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina isikhongozeli sivalwe ngokuqinileyo kwaye usigcine kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engena moya ikude kwizinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
Tranexamic Acid
C8H15NO2 157.2
i-trans-4-(Aminomethyl) i-cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans [1197-18-8].
INGCACISO
I-Tranexamic Acid iqulethe i-NLT 99.0% kunye ne-NMT 101.0% ye-C8H15NO2, ibalwe ngokomisiweyo.
UKUCHAZA
• I-Infrared Absorption <197K>
UVAVANYO
• Inkqubo
Isampuli yesisombululo: 140 mg yeTranexamic Acid kwi-20 mL yeglacial acetic acid
Inkqubo yeTitrimetric
(Jonga i-Titrimetry <541>.)
Imowudi: Ukubhalwa ngokuthe ngqo
I-Titrant: 0.1 N i-perchloric acid VS
Ukubonwa kwendawo yokugqibela: I-Potentiometric
Uhlalutyo
Isampulu: Isampuli yesisombululo
I-Titrate nge-0.1 N perchloric acid VS, imisela i-endpoint potentiometrically.Yenza ititration engenanto.
I-mL nganye ye-0.1 N perchloric acid ilingana ne-15.72 mg ye-C8H15NO2.
Indlela yokwamkela: 99.0% -101.0% kwisiseko esomileyo
UBUNGCOLA
Ukungcola Kwezinto Eziphilayo
• Intsalela ekuZisweni <281>: NMT 0.1%;1-g isampuli isetyenziswa
• Iintsimbi ezinzima, Indlela II <231>: NMT 10 ppm
• I-Chloride ne-Sulfate, i-Chloride <221>: Ingxenye ye-0.51-g ayibonisi i-chloride ngaphezu kokuhambelana ne-0.1 mL ye-0.020 N hydrochloric acid (0.014%).
Ukungcola Okuphilayo
• Inkqubo
Isigaba seselula: Dissolve 11.0 g ye-anhydrous monobasic sodium phosphate kwi-500 mL yamanzi, kwaye ungeze i-5 mL ye-triethylamine, ilandelwa yi-1.4 g ye-sodium lauryl sulfate.Lungisa nge-asidi ye-phosphoric ehlanjululweyo (10% w / w) kwi-pH ye-2.5, kwaye uhlambulule ngamanzi kwi-600 mL.Xuba esi sisombululo kunye ne-400 mL ye-methanol.
Isisombululo sokufaneleka kwenkqubo: 0.2 mg / mL ye-USP Tranexamic Acid RS kunye ne-0.002 mg / mL ye-USP Tranexamic Acid eNxulumene neCompound C RS emanzini
Isisombululo esisemgangathweni: 50 µg/mL ye-USP Tranexamic Acid RS emanzini
Isisombululo sesampuli: 10 mg/mL yeTranexamic Acid emanzini
Inkqubo yeChromatographic
(Jonga iChromatography <621>, Ukufaneleka kweNkqubo.)
Indlela: LC
Umtshina: UV 220 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha i-L1
Izinga lokuhamba: 1 mL / min
Ubungakanani betofu: 20 µL
Ixesha lokuqhuba: amaxesha ama-3 ixesha lokugcinwa kwe-tranexamic acid
Ukufaneleka kwenkqubo
Isampulu: Isisombululo sokufaneleka kwenkqubo
Iimfuno zokufaneleka
Isisombululo: I-NLT 2.0 phakathi kwe-Tranexamic Acid kunye ne-0.002 mg / mL ye-tranexamic acid enxulumene nekhompawundi C
Uhlalutyo
Iisampulu: Isisombululo esisemgangathweni kunye nesisombululo seSampuli
Bala ipesenti yokungahlambuluki komntu ngamnye kwisahlulo seTranexamic Acid ethathiweyo:
Isiphumo = (rU/rS) × (CS/CU) × (0.1F)
i-rU = impendulo ephezulu yokungcola ngalunye kwisisombululo seSampuli
rS = impendulo ephezulu ye-tranexamic acid kwisisombululo esiPhakathi
CS = ukuxinwa kwe-USP Tranexamic Acid RS kwisisombululo soMgangatho (µg/mL)
I-CU = i-concentration ye-Tranexamic Acid kwi-Sample solution (mg/mL)
F = isalamane sempendulo (jonga iTheyibhile yoku-1)
Iinqobo zokwamkelwa
Ukungcola komntu ngamnye: Jonga iTheyibhile yoku-1 yokungacoceki.
Ubumdaka bubonke: NMT 0.2%
[Qaphela-Ungakhathali nayiphi na incopho engaphantsi kwe-0.025%.]
Itheyibhile yokungcola 1
Igama lokuGcina iSinxulumano Ixesha leMpendulo enxulumeneyo Umgaqo wokwamkelwa kweFactor, NMT (%)
Tranexamic acid enxulumene ikhompawundi Aa 2.1 1 0.1
Tranexamic acid ezinxulumene ikhompawundi Bb 1.5 1.2 0.2
Tranexamic acid ezinxulumene ikhompawundi Cc 1.1 0.005 0.1
I-Tranexamic Acid 1.0 1.0 —
Tranexamic acid ezinxulumene ikhompawundi Dd 1.3 0.006 0.1
a trans,trans-4,4¢-(Iminodimethylene)di(cyclohexanecarboxylic)asidi.
b cis-4-(Aminomethyl) cyclohexanecarboxylic acid.
c (RS) -4- (Aminomethyl) i-cyclohex-1-enecarbocylic acid.
d 4-Aminomethyl benzoic acid.
IIMVAVANYO EZITHILE
• Ilahleko ekomisweni <731>: Yomisa i-1.00 g kwi-105 phantsi kwe-vacuum nge-2 h.Ilahlekelwa yi-NMT nge-0.5% yobunzima bayo.
IIMFUNO EZONGEZELELWEYO
• Ukupakishwa kunye noGcino: Londoloza kwizikhongozeli eziqinileyo, kwaye ugcine kwiqondo lobushushu elingagqithiyo kuma-30.
• IMigangatho yeReferensi ye-USP <11>
USP Tranexamic Acid RS Cofa ukujonga iSakhiwo
USP Tranexamic Acid Related Compound C RS
(RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
C8H13NO2 155
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
Iimpawu zeHazard Xi - Irritant
Iikhowudi zoMngcipheko 36/37/38 - Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nesikhumba.
Inkcazelo yoKhuseleko
S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36 - Nxiba iimpahla ezifanelekileyo zokukhusela.
I-S37/39 - Nxiba iiglavu ezifanelekileyo kunye nokukhusela amehlo / ubuso
WGK eJamani 2
RTECS GU8400000
Ikhowudi yeHS 2922491100
I-Hazard Class IRRITANT
Ubutyhefu LD50 kwiimpuku, iimpuku (mg/kg): 1500, 1200 iv (Melander)
I-Tranexamic Acid (CAS: 1197-18-8) iphuma kwi-amino acid lysine.Tranexamic acid (idla ngokuthengiswa kwifom yethebhulethi njenge-Lysteda kunye ne-IV njenge-Cyklokapron e-US kunye ne-Transamin, i-Transcam e-Asia, kunye ne-Espercil eMzantsi Melika) idla ngokumiselwa ukopha kakhulu.I-Tranexamic acid i-antifibrinolytic ekhuphisanayo inqanda ukusebenza kwe-plasminogen kwi-plasmin, i-molecule ejongene nokuthotywa kwe-fibrin.I-Fibrin yinkqubo esisiseko yokwakhiwa kwehlwili legazi kwi-hemostasis.I-Tranexamic acid inomlinganiselo wamaxesha angama-8 kumsebenzi we-antifibrinolytic we-analogue endala, i-ε-aminocaproic acid.Yaqala ukunikwa ilungelo elilodwa lomenzi ngo-1957 kwaye yafumana imvume yokuqala yase-US ngo-1986. I-Tranexamic Acid Applicaiton Isetyenziswa njengezinto zokuthambisa zokwenza mhlophe Isetyenziswa ngokubanzi kwikliniki kwiinkalo zotyando, amayeza angaphakathi, i-urology, i-obstetrics kunye ne-gynecology, njl. ukopha okungaqhelekanga ngexesha lotyando, njl njl. Ithathwa njengeyeza le-hemostatic, elisetyenziselwa kakhulu ukopha emva kotyando olukhulu kunye nasemva kokubeleka.Ngokuqinisekileyo, i-hemostasis mhlawumbi sesona sizathu sincinci sokuba kutheni ezininzi iintlama zamazinyo zongezwa ngethemba lokuba nefuthe.
I-Tranexamic Acid (CAS: 1197-18-8)
Utyando lwentliziyo
Ngokuqhelekileyo isetyenziselwa utyando lwentliziyo, zombini kunye nangaphandle kwe-cardiopulmonary bypass.Ithatha indawo ye-aprotinin.
Ukopha exesheni
Isetyenziswa njengonyango lokuqala lwe-nonhormonal yokopha kwe-uterine engasebenziyo, kunye nokopha okukhulu okunxulumene ne-uterine fibroids.Uphononongo lwakutsha nje lubonise izigulane ezinyangwa nge-tranexamic acid kunokwenzeka ukuba zibe ne-thrombosis kunye ne-necrosis kwi-fibroids yazo, kwaye zinokukhokelela kwiintlungu kunye nomkhuhlane.
Isiphumo sokwenza mhlophe
Izifundo zeklinikhi iminyaka ziye zangqina ukuba i-tranexamic acid inokunciphisa indawo ngokufanelekileyo kwaye ngokukhawuleza, enceda ukubonisa ulusu olumhlophe olugqibeleleyo kunye noluqaqambileyo.Umphumo wokususa indawo we-tranexamic acid malunga namaxesha angama-50 ngaphezu kwe-Vitamin C, kunye namaxesha e-10 ngaphezu kwe-AHA.Umda wogxininiso wokusetyenziswa yi-2% -3%, kwaye kwi-cosmetics isixa sijikeleze i-0.5%
1. Ukuzinza okulungileyo
Xa kuthelekiswa nezithako ezimhlophe zendabuko, i-tranexamic acid inozinzo oluphezulu, i-asidi kunye nokumelana ne-alkali, kwaye ayichatshazelwa lula yimeko yokushisa;Akukho khuseleko lomthwali, akukho monakalo wenkqubo yokuhanjiswa, akukho vuselelo.
2. Inkqubo yesikhumba kulula ukuyifunxa
Kufanelekile ngokukodwa kwiindawo ezikhanyisayo, ezimhlophe kunye nokulinganisa ithoni yesikhumba ngokubanzi.Ukongeza ekukhanyiseni amabala, i-tranexamic acid inokuphucula ukungafihli kombala wolusu lulonke kunye nokuba buthuntu kobunzima bolusu lwendawo.
3. Iyakwazi ukucima amabala amnyama, i-yellow freckles, i-acne marks, njl
Amabala amnyama abangelwa umonakalo we-UV kunye nokuguga kwesikhumba kunye nezinye izinto.I-asidi ye-clotting inokuthintela umsebenzi we-tyrosinase kunye ne-melanocytes, ukunciphisa ukuveliswa kwe-melanin kwi-basal layer ye-epidermis, kwaye ibe nefuthe lokususa amabala abomvu.
4. Ukhuseleko oluphezulu
Olona gxininiso luphezulu kwizithambiso yi-2% ~ 3%.
5. Umphumo wokuba mhlophe
I-Tranexamic Acid ifanelekile kuzo zonke iintlobo zesikhumba sokususa i-pigmentation, isikhumba esimhlophe kunye nokunciphisa amabala, anje: I-Pigmentation emva kokuphuma kwelanga;Amabala amnyama;Ulusu olubuthathaka;I-acne kunye nokuvuvukala;Ukhathalelo lwe-postoperative emva kwe-laser, unyango olulula lwe-pulsed.
