I-Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
I-Shanghai Ruifu Chemical Co., Ltd. ngumenzi ohamba phambili we-Vitamin E-TPGS (Tocofersolan) (i-CAS: 9002-96-4) enomgangatho ophezulu.I-Ruifu Chemical inokubonelela ngenkonzo yehlabathi jikelele, ixabiso elikhuphisanayo, inkonzo egqwesileyo, encinci kunye nezixa ezininzi ezikhoyo.Thenga iVithamin E-TPGS,Please contact: alvin@ruifuchem.com
| Igama leMchiza | Vitamin E Polyethylene Glycol Succinate |
| Izithethantonye | I-Vitamin E-TPGS;TPGS;iTocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Ubume beStokhwe | Kwisitokhwe, isikali soRhwebo |
| Inombolo yeCAS | 9002-96-4 |
| Ifomula yeemolekyuli | C33H54O5.(C2H4O)n |
| Indawo yokunyibilika | 34.0 ~ 38.0℃ |
| Ukuxinana | 1.01g/cm3 |
| Inovakalelo | Ukungeva kuMoya, ukuKhanya, uBuvane ukufuma |
| WGK eJamani | 2 |
| Ugcino Temp. | Indawo epholileyo neyomileyo (2~8℃) |
| I-COA kunye ne-MSDS | Iyafumaneka |
| Isampulu | Iyafumaneka |
| Chemical Family | I-Vitamin E ephumayo |
| Uphawu | Ruifu Chemical |
| Izinto | ImiGangatho yokuHlola | Iziphumo |
| Imbonakalo | Okumhlophe-kuMhlophe ukuya kuMthubi oMthubi oLuqilima | Iyahambelana |
| Ukuchongwa (GC) | Ixesha lokugcinwa kwencopho enkulu yesisombululo sesampulu sihambelana nesombululo soMgangatho | Iyahambelana |
| Indawo yokunyibilika | 34.0 ~ 38.0℃ | 36.0 ~ 36.6℃ |
| Uvavanyo lwe-D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| I-Tocopherol yasimahla | ≤1.5% | Iyahambelana |
| Ukujikeleziswa okuthe ngqo | ≥+24.0 ° | + 24,5 ° |
| Ukunyibilika emanzini | Isampula ye-20g inokuchithwa kwi-80ml yamanzi abilayo | Cacisa Ngesithuba se-3h |
| Ixabiso le-Acid | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22ml |
| Iintsimbi ezinzima (Pb) | ≤10ppm | <10ppm |
| IArsenic (As) | ≤1ppm | <1ppm |
| Inkokeli | ≤3ppm | <3ppm |
| IMercury (Hg) | ≤0.1ppm | <0.010ppm |
| Izinyibilikisi ezishiyekileyo | ||
| I-Ethyl Acetate | ≤50ppm | Ayifunyanwa |
| I-Ethanol | ≤50ppm | 23ppm |
| Ukubalwa kwePleti iyonke | ≤1000CFU/g | <10CFU/g |
| Igwele kunye nokungunda | ≤100CFU/g | <10CFU/g |
| Salmonella | Ibi | Ibi |
| Escherichia Coli | Ibi | Ibi |
| Psendomonas Aeruginosa | Ibi | Ibi |
| Staphylococcus Aureus | Ibi | Ibi |
| I-Infrared Spectrum | Iyahambelana neSakhiwo | Iyahambelana |
| Ukuqukumbela | Imveliso ivavanyiwe kwaye iyahambelana neenkcukacha ezinikiweyo | |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina kwisitya esivaliweyo.Gcina kwindawo epholileyo, eyomileyo (2~8℃) kunye nendawo yokugcina impahla engenamoya kude nezinto ezingahambelaniyo.Khusela ukukhanya kunye nokufuma.
Ukuhambisa ngenqanawe:Zisa kwihlabathi liphela ngomoya, ngeFedEx / DHL Express.Ukubonelela ngokukhawuleza nangokuthembekileyo.
INGCACISO
I-Vitamin E Polyethylene Glycol Succinate ngumxube owenziwe yi-esterification ye-d-alpha tocopheryl acid succinate kunye ne-polyethylene glycol.Umxube we-ester uquka ngokuyinhloko i-polyethylene glycol ye-mono-esterified kunye nenani elincinci le-di-esterified polyethylene glycol.Iqulethe i-NLT 25.0% ye-d-alpha tocopherol (C29H50O2).
UKUCHAZA
• A. UVavanyo lweChromatographic yegesi
Uhlahlelo: Qhubeka njengoko kuchaziwe kuvavanyo lomxholo weAlpha Tocopherol.
Iinqobo zokwamkelwa: Ixesha lokugcinwa kwencopho enkulu yeSampuli yesisombululo ihambelana nesombululo soMgangatho.
UHLELO
• Umxholo weAlpha Tocopherol
I-solvent: i-0.25 mL ye-phenolphthalein TS kwi-1 L yotywala
Isisombululo somgangatho wangaphakathi: 12 mg / mL ye-ethyl arachidate kwi-isooctane
Isisombululo esisemgangathweni: Dlulisa i-32.5 mg ye-USP Alpha Tocopherol RS kwiflask yokusabela efanelekileyo.Yongeza i-2 mL ye-pyridine kunye ne-0.5 mL ye-N, O-bis (trimethylsilyl) trifluoroacetamide ne-1% ye-trimethylchlorosilane, kwaye ushushu i-flask kwi-100 kwi-10 min.Pholisa i-flask, yongeza i-5.0 mL yesisombululo esisemgangathweni sangaphakathi silandelwa yi-20 mL ye-isooctane, kwaye ungcangcazele.
Isampuli yesisombululo: Dlulisa ubungakanani obulingana ne-0.100–0.160 g ye-Vitamin E Polyethylene Glycol Succinate enyibilikisiweyo ngama-60 kwityhubhu yenkcubeko (malunga ne-20 cm ubude kunye ne-2.5 cm ububanzi) ixhotyiswe nge-screw cap.Yongeza i-40-50 mg ye-ascorbic acid kunye ne-chips ezimbalwa ezibilisayo, ilandelwa yi-20 mL ye-Solvent.[Qaphela—Reflux isisombululo ngobunono ngaphandle kokuphuma kwemixholo.] Beka ityhubhu kwindawo yokufudumeza ebekwe kwi-100-150.Xa isampuli ichithwe ngokupheleleyo, yongeza i-0.25 g ye-potassium hydroxide, kwaye uqhubeke u-reflux kwi-30 min.Susa ityhubhu ekushiseni, kwaye ngelixa iziqulatho ziseshushu, yongeza i-1-2 mL ye-hydrochloric acid dropwise de umbala opinki unyamalale.[Isilumkiso—Ukusabela okumangalisayo.Vumela iasidi ukuba ithontsize ngaphakathi kumbhobho ukunqanda ukuchaphaza.] Pholisa ityhubhu, uze uhlambe amacala ombhobho nge-20 mL yamanzi.Yongeza i-5.0 mL yesisombululo esisemgangathweni sangaphakathi, i-cap, kwaye ushukumise ukuqinisekisa ukuxuba ngokucokisekileyo.Vumela ityhubhu ukuba ime kude kube yimigangatho emibini eyahlukileyo.Dlulisa i-2.5-3.5 mL yoluhlu oluphezulu kwi-flask yokuphendula efanelekileyo, kwaye ungeze i-2.0 mL ye-pyridine elandelwa yi-2.5 mL ye-N, O-bis (trimethylsilyl) trifluoroacetamide ne-1% trimethylchlorosilane.Ukushisa i-flask kwi-100 ye-10 min.Phola, kwaye wongeze i-12 mL ye-isooctane.
Inkqubo yeChromatographic
(Jonga iChromatography 621, Ukufaneleka kweNkqubo.)
Indlela: GC
Umtshina: Iionization yomlilo
Ikholomu: 0.25-mm × 15-m fused-silica capillary;igqunywe ngefilimu ye-0.25-µm yesigaba G27
Ubushushu
Isitofu: 280
Umtshina: 345
Uluhlu: Jonga iTheyibhile 1.
Uluhlu loku-1
Iqondo lobushushu lokuqala(°) Irempu yoBubushushu (°/min) iBuzulu yokuGqibela (°) Bamba iXesha kuBubushushu bokugqibela (min)
260 20 340 1
Irhasi yokuthwala: iHelium
Izinga lokuhamba: 1.5 mL / min
Ubungakanani bokutofa: 1 µL
Uhlobo lwesitofu: Umlinganiselo wokwahlula, 200:1
Ukufaneleka kwenkqubo
Isampulu: Isisombululo esisemgangathweni
Iimfuno zokufaneleka
Umba wokubala: NMT 2.0 yencopho yealpha tocopherol
Utembuko lomgangatho ozalanayo: I-NMT 2.0% yomlinganiselo wendawo yencopho yealpha tocopherol ukuya kwindawo yencopho esemgangathweni yangaphakathi
Uhlalutyo
Iisampulu: Isisombululo esisemgangathweni kunye neSicombululo seSampuli
Bala ipesenti ye-d-alpha tocopherol (C29H50O2) kwisahlulo seVithamin E Polyethylene Glycol Succinate ethathiweyo:
Isiphumo = (RU/RS) × (WS/WU) × 100
RU = umlinganiselo womgangatho wangaphakathi (indawo ephezulu ye-alpha tocopherol/indawo encopho yomgangatho wangaphakathi) ukusuka kwisisombululo seSample
RS= umlinganiselo womgangatho wangaphakathi (indawo eyincopho yealpha tocopherol/incopho yendawo yomgangatho wangaphakathi) ukusuka kwisisombululo soMgangatho
I-WS= ubunzima be-USP Alpha Tocopherol RS esetyenzisiweyo ukulungisa isisombululo soMgangatho (mg)
WU= ubunzima beVithamin E Polyethylene Glycol Succinate ethathiweyo ukulungisa isisombululo seSampule (mg)
Indlela yokwamkela: NLT 25.0%
IIMVAVANYO EZITHILE
• Ukujikeleziswa kwe-Optical, ukujikeleza okuKhethekileyo 781S
[Qaphela-Olu vavanyo luchonga i-d-alpha tocopherol emva kwe-saponification.]
Isisombululo sesampuli: Dlulisa i-0.9 g ye-Vitamin E Polyethylene Glycol Succinate, etyhidiweyo kwi-60, kwi-tube yokuvavanya efanelekileyo efakwe i-cap, kwaye inyibilike kwi-10.0 mL yotywala.Beka ityhubhu kwindawo yokufudumeza ebekwe kwi-100-105.[Qaphela-Reflux isisombululo ngobunono ngaphandle kokuphuma kwemixholo.] Xa isampuli ichithwe ngokupheleleyo, yongeza i-2-3 iipelisi ze-sodium hydroxide, kwaye uqhubeke uhlaziya i-30 min.Susa ityhubhu ekushiseni, kwaye ngelixa iziqulatho ziseshushu, zithintele ukusebenzisa i-phenolphthalein njengesalathisi ngokufaka kancinci i-10 mL yomxube wamanzi kunye ne-hydrochloric acid (1: 1) de kube umbala opinki unyamalale.[Isilumkiso-Ukusabela okungaqhelekanga.Vumela isisombululo seasidi sithontsize ngaphakathi kumbhobho ukunqanda ukuchaphaza.] Pholisa umbhobho, ikepusi, kwaye ushukumise de izinto ezingaphakathi zixutywe kakuhle.Yongeza i-25.0 mL ye-heptane, i-cap, kwaye ugubungele i-1 min ukuqinisekisa ukuxuba ngokucokisekileyo.Vumela ityhubhu ukuba ime kude kube yimigangatho emibini eyahlukileyo.Dlulisa umaleko ophezulu kwityhubhu yenkcubeko ecocekileyo, eyomileyo, uze udibanise i-10.0 mL yamanzi kwisisombululo esifunyenweyo.I-cap, vuthulula, kwaye uvumele iileya ukuba zahlukane.Dlulisa umaleko ophezulu kwi-tube ecocekileyo, eyomileyo.Yongeza i-10.0 mL yesisombululo se-potassium ferricyanide, elungiselelwe ngokunyibilikisa i-2 g ye-potassium ferricyanide kwi-10.0 mL ye-0.2 M i-sodium hydroxide, kwaye ubeke indawo ye-cap.Gcoba ngamandla kwi-45 s, kwaye uvumele iileyile ukuba zihlukane kwi-30 min.Ukuba uluhlu oluphezulu lwe-heptane lucacile, qhubeka nomlinganiselo wokujikeleza okuthe ngqo;ukuba ayicacanga, yome phezu kwe-anhydrous sodium sulfate ngaphambi kokuba uqhubeke novavanyo.[Qaphela-Sebenzisa iziphumo zovavanyo loMxholo weAlpha Tocopherol ukubala ujikelezo oluthile.]
Indlela yokwamkela: NLT +24.0
• Ukunyibilika emanzini
Isampulu: I-20 g ye-Vitamin E enyibilikileyo ye-Polyethylene Glycol Succinate
Uhlalutyo: Beka iSampulu kwisikhongozeli seglasi kwi-stirrer magnetic.Kwangoko yongeza i-80 mL yamanzi abilayo ngelixa uvuselela.Vumela ukupholisa kwiqondo lokushisa kunye nokuvuselela rhoqo.
Iinqobo zokwamkela: Isisombululo siyacaca kwiiyure ezi-3.
• Ixabiso le-Acid
Isampuli: 1 g ye-Vitamin E Polyethylene Glycol Succinate
Uhlalutyo: Ukunyibilikisa iSampulu kwi-25 mL yomxube wotywala kunye ne-ether (1: 1) engathathi hlangothi kwi-phenolphthalein kunye ne-0.1 N sodium hydroxide.Yongeza i-0.5 mL ye-phenolphthalein TS, kunye ne-titrate kunye ne-0.10 N i-sodium hydroxide de isisombululo sihlala sipinki ngokukhawuleza emva kokugubha i-30 s.
Indlela yokwamkela: NMT 0.027 mEq/g, ilingana ne-NMT 0.27 mL ye-0.10 N sodium hydroxide
IIMFUNO EZONGEZELELWEYO
• Ukupakishwa nokugcinwa: Yigcine kwizikhongozeli eziqinileyo, kwaye ugcine ukhuselwe ekukhanyeni.
• Ukufakwa ileyibhile: Ukufakwa kweelebhile kubonisa umxholo we-d-alpha tocopherol, ochazwe ngo-mg/g.
• ImiGangatho yeReferensi ye-USP 11
USP Alpha Tocopherol RS
Ukuthenga njani?Nceda uqhagamshelaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Amava Eminyaka Eli-15?Sineminyaka engaphezu kwe-15 yamava ekwenziweni nasekuthumeleni kumazwe angaphandle uluhlu olubanzi oluphezulu lwamayeza aphakathi okanye amachiza alungileyo.
Iimarike eziphambili?Thengisa kwimarike yasekhaya, eMntla Melika, eYurophu, eIndiya, eKorea, eJapan, eOstreliya, njl.
Iingenelo?Umgangatho ophezulu, ixabiso elifikelelekayo, iinkonzo zengcali kunye nenkxaso yobugcisa, ukuhanjiswa ngokukhawuleza.
UmgangathoIsiqinisekiso?Inkqubo yokulawula umgangatho ongqongqo.Izixhobo zobuchwephesha zokuhlalutya ziquka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njl.
Iisampulu?Uninzi lweemveliso zibonelela ngeesampulu zasimahla zokuvavanya umgangatho, iindleko zokuthumela kufuneka zihlawulwe ngabathengi.
Factory Audit?Uphicotho-zincwadi lwasefektri wamkelekile.Nceda wenze idinga kwangaphambili.
MOQ?Akukho MOQ.Umyalelo omncinci wamkelekile.
Ixesha lokuzisa? Ukuba ngaphakathi kwesitokhwe, ukuhanjiswa kweentsuku ezintathu kuqinisekisiwe.
Ezothutho?Nge-Express (FedEx, DHL), ngoMoya, ngoLwandle.
Amaxwebhu?Emva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njl.
Udibaniso lweSiko?Inokubonelela ngeenkonzo zesiko lokudibanisa ukuze zilungele iimfuno zakho zophando.
Immimiselo yokuhlawula?I-invoyisi yeProforma iya kuthunyelwa kuqala emva kokuqinisekiswa kwe-odolo, efakwe kwiinkcukacha zethu zebhanki.Intlawulo nge-T / T (i-Telex Transfer), i-PayPal, i-Western Union, njl.
I-Vitamin E I-Polyethylene Glycol Succinate (i-Vitamin E-TPGS; i-TPGS; i-Tocofersolan) (i-CAS: i-9002-96-4) yimveliso yokwenziwa.Ifumaneka njenge-waxy emhlophe-kumhlophe ukuya kumthubi eluthuthu. Iqinile kwaye ayinancasa.Ngokwekhemikhali, ngumxube oqulunqwe ngokuyintloko kwi-polyethylene glycol 1000, i-polyethylene glycol 1000, i-polyethylene glycol 1000, kunye ne-tocopherol yamahhala.
I-Vitamin E Polyethylene Glycol Succinate isetyenziswe ngokubanzi kuphando lwamachiza, njenge-solubilizer, umgqugquzeli wokufunxa, i-emulsifier, i-plasticizer kunye nomthwali wenkqubo yokuhanjiswa kweziyobisi ezingenakunyibilika emanzini okanye ezinamafutha, ezifana nokusasazeka okuqinileyo, umthwali wokuhanjiswa kweziyobisi kwi-ocular, umthwali we-intranasal. ukuhanjiswa kweziyobisi, njl. Njengezongezo zokutya.
I-Vitamin E i-Polyethylene Glycol Succinate yi-derivative yamanzi e-soluble ye-vitamin E, yenziwa ngokusabela kwiqela le-carboxyl le-vitamin E succinate kunye neqela le-hydroxyl ye-polyethylene glycol.Ngenxa yokuba iqulethe zombini i-vitamin E ye-lipophilic kunye ne-polyethylene glycol hydrophilic chain chain, ineempawu ezintle ze-surfactant kunye ne-solubility yamanzi, enokunyusa kakhulu ukufunxa kweziyobisi ezinganyibilikiyo kwi-gastrointestinal tract, ukunyuka kwe-bioavailability.
Kwiminyaka yakutshanje, uphando oluninzi luye lwafumanisa ukuba i-TPGS ayinakusetyenziswa nje kuphela njengabancedisi bamachiza, kodwa ineempawu ezininzi ezizodwa, njengeziphuculi zokufunxa kunye ne-multidrug resistance reversal agents, i-TPGS ingasetyenziselwa kwiiprodrugs, i-micelles, i-liposomes, i-TPGS-copolymer. abathwali ukuphucula i-solubility, permeability kunye nokuzinza kwamalungiselelo, ukwenzela ukuba kuphunyezwe ukukhululwa okucothayo, okulawulwayo kunye nokujoliswe kuyo, ukukhuthaza ukufunxwa kweziyobisi.
1. I-Pharmaceutical - I-Vitamin E-TPGS iphakamisa kakhulu ukufunxa, i-bioavailability kunye nokusebenza kwezithako zonyango (APIs)
2. Izongezo zokutya - I-Vitamin E-TPGS isetyenziselwa ukwenza izongezo, ngakumbi ezo zidalwe ukuphucula i-labsorption ye-vitamin E kunye nezinye izondlo ze-lipophilic kunye ne-nutraceuticals.
3. Ukutya kunye nesiselo - IVithamin E-TPGS inokusetyenziselwa ukomeleza ukutya kunye neziselo, iziselo zezemidlalo, amanzi kunye nejusi.
4. Ukhathalelo lomntu - I-Vitamin E-TPGS isebenza njenge-ethanol yamahhala, i-hypoallergenic, i-emulsifier engacasuli / i-excipient ekunyamekeleni komntu kunye nezicelo zokuthambisa.
5. IiMveliso zeSondlo seZilwanyana - IVithamin E-TPGS ibonelela ngevithamin E enokufunxa kakhulu kunye nebhayoloji efumanekayo kwizilwanyana ezingafunxanga ngokufanelekileyo iindlela zesintu zevithamin E.
I-Vitamin E i-polyethylene glycol succinate yi-esterified vitamin E (tocopherol) ephuma kuqala esetyenziswa njenge-solubilizer okanye i-emulsifying agent ngenxa yeempawu zayo ze-surfactant.Ngokwesakhiwo, i-amphipathic kunye ne-hydrophilic, ngokungafaniyo ne-tocopherols, kwaye ngoko ke i-derivative yamanzi e-soluble enokuthi isetyenziswe kwiifomyula zamachiza ezifana ne-capsules, iipilisi, i-hot-melt extrusion, i-microemulsions, iimveliso ze-topical, kunye ne-parenterals.Esinye sezicelo ezibaluleke kakhulu kukusetyenziswa kwayo njengesithuthi sokuqulunqa ukuhanjiswa kweziyobisi ezisekelwe kwi-lipid.Ingaphinda isetyenziswe njengomthombo we-vitamin E. I-Vitamin E i-polyethylene glycol succinate ibonakaliswe ngokubhekiselele kwindlela yayo yokusebenza kwaye ifundwe njenge-Pglycoprotein inhibitor.
I-Vitamin E i-polyethylene glycol succinate ayihambelani ne-acids eqinile kunye ne-alkali enamandla.
GRAS zidweliswe.Ibandakanyiwe kwi-FDA ye-Inactive Ingredients Database (isisombululo se-ophthalmic okanye amaconsi; ii-capsules zomlomo, isisombululo, ithebhulethi; isisombululo se-topical okanye amaconsi).Ibandakanyiwe kuLuhlu lwaseKhanada lweZithako ezaMkelweyo ezingezizo amayeza.
