1- (2,3-Dichlorophenyl) piperazine Hydrochloride CAS 119532-26-2 Aripiprazole Intermediate Purity>99.0% (HPLC)
Olupese Ipese Intermediates ti Aripiprazole Pẹlu Giga Mimo
Aripiprazole API CAS 129722-12-9
1- (2,3-Dichlorophenyl) piperazine Hydrochloride CAS 119532-26-2
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0
7- (4-Bromobutoxy) -3,4-Dihydro-2 (1H) - Quinolinone CAS 129722-34-5
Orukọ Kemikali | 1- (2,3-Dichlorophenyl) Piperazine Hydrochloride |
Awọn itumọ ọrọ sisọ | 2,3-DCPP HCl;1- (2,3-Dichlorophenyl) piperazine HCl;Aripiprazole EP Aimọ B;Aripiprazole Jẹmọ Agbo C |
Nọmba CAS | 119532-26-2 |
NỌMBA CAT | RF-PI2268 |
Iṣura Ipo | Ni Iṣura, Agbara iṣelọpọ 30 MT / osù |
Ilana molikula | C10H12Cl2N2 · HCl |
Òṣuwọn Molikula | 267.58 |
Ojuami Iyo | 245.0 ~ 247.0 ℃ |
Ibi ipamọ & Ifamọ | Hygroscopic.Awọn iwọn otutu ibaramu |
Solubility ninu Omi | Tiotuka ninu Omi |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Pa-White Powder |
Mimọ / Analysis Ọna | > 99.0% (HPLC) |
Pipadanu lori Gbigbe | <0.50% |
Aloku lori Iginisonu | <0.10% |
Aimọ Kanṣoṣo | <0.50% |
Lapapọ Awọn Aimọ | <1.00% |
Awọn irin Heavy (gẹgẹbi Pb) | ≤20ppm |
Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji ti Aripiprazole (CAS: 129722-12-9) |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Hygroscopic.Tọju kuro lati omi / ọrinrin ati awọn aṣoju oxidizing.Jeki apo eiyan naa ni wiwọ ki o si gbe e si ibi ti o tutu, gbẹ ati ipo atẹgun daradara.Itaja labẹ inert gaasi
1- (2,3-Dichlorophenyl) piperazine Hydrochloride (CAS: 119532-26-2) jẹ agbedemeji pataki ti Aripiprazole (CAS: 129722-12-9).Aripiprazole jẹ iru tuntun ti awọn itọsẹ quinoline ti o ni ọra ti o ga pupọ, awọn ipa elegbogi rẹ ti iwa ni pe kii ṣe awọn antagonist olugba postsynaptic dopamine D 2 nikan, ṣugbọn tun presynaptic dopamine D 2 agonist olugba, o tun le ṣe itara D 1, D 3, D 4 awọn olugba;o ni ipa meji ti imuṣiṣẹ apakan tabi antagonistic olugba lori olugba 5-HT 1A;o ni igbese atako patapata lori olugba 5-HT 2A.Ẹya yii yatọ si iran akọkọ, ati awọn antipsychotics atypical eyiti o jẹ ti awọn oogun antipsychotic iran-keji, ati nitorinaa o jẹ amuduro eto dopamine tabi antipsychotic iran kẹta.Niwọn igba ti o ti n ta ni ọja, o jẹ lilo akọkọ ni schizophrenia ile-iwosan, itọju awọn rudurudu ti o ni ipa ati awọn rudurudu ọpọlọ miiran.Gẹgẹbi awọn iwe-iwe, aripiprazole ni awọn ipa pataki lori schizophrenia rere ati awọn aami aiṣan ti ko dara ati aibalẹ, ibanujẹ, iṣẹ iṣaro, lakoko ti ailewu ti o ga julọ.O tun royin pe oogun naa tun le ṣe itọju awọn rudurudu ọpọlọ miiran, gẹgẹbi awọn rudurudu iṣesi awọn iṣẹlẹ manic, iyawere agbalagba ti o ni nkan ṣe pẹlu awọn rudurudu ọpọlọ, awọn rudurudu aibalẹ, awọn rudurudu ihuwasi awọn ọmọde, ibanujẹ.Lasiko yi, Bristol-Myers Squibb ati Otsuka Pharmaceutical Company kede pe European Union ti fọwọsi Abilify (aripiprazole) ni itọju ohun elo atokọ schizophrenia.