2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Agbedemeji Remdesivir COVID-19
Olupese Ipese Iṣowo Remdesivir ati Awọn agbedemeji ibatan pẹlu Didara Giga
Remdesivir CAS 1809249-37-3
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Orukọ Kemikali | 2,3,5-Tri-O-benzyl-D-ribonolactone |
Awọn itumọ ọrọ sisọ | 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone;Remdesivir Intermediate |
Nọmba CAS | 55094-52-5 |
NỌMBA CAT | RF-PI301 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C26H26O5 |
Òṣuwọn Molikula | 418.49 |
Ojuami Iyo | 54.0-55.0 ℃ |
Ibi ipamọ Ipo | Iwọn otutu yara |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Yellowish tabi White Ri to |
Solubility | Tiotuka ni CH2Cl2 ati Insoluble ni H2O |
NMR ati MS | Yẹ ki o tẹle |
Idanimọ | IR ati TLC |
Ọrinrin | ≤1.0% |
Aloku lori Iginisonu | ≤0.50% |
Eyikeyi Olukuluku aimọ | ≤0.50% |
Awọn irin Heavy | ≤50ppm |
HPLC (210nm) | ≥99.0% |
HPLC (ELSD) | ≥99.0% |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji ti Remdesivir (CAS 1809249-37-3) |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
2,3,5-Tri-O-benzyl-D-ribonolactone (CAS 55094-52-5) jẹ agbedemeji Remdesivir.Remdesivir (CAS 1809249-37-3) jẹ oogun apakokoro aramada ni kilasi ti awọn afọwọṣe nucleotide, ti a lo ninu itọju COVID-19.Remdesivir (GS-5734) jẹ afọwọṣe antiviral nucleoside aramada ti o ṣe idiwọ ọlọjẹ jedojedo murine (MHV) pẹlu iru EC50 bii SARS-CoV ati MERS-CoV.Coronaviruses (CoVs) jẹ imọ-daadaa, awọn ọlọjẹ RNA ti o ni okun kan ti o ṣe akoran ọpọlọpọ awọn ogun ẹranko.Ninu eniyan, awọn CoVs ni a mọ bi igbagbogbo nfa otutu ati ẹdọforo titi ti farahan ti arun coronavirus nla ti atẹgun nla (SARS-CoV) ni ọdun 2002 ati Arun atẹgun atẹgun Aarin Ila-oorun coronavirus (MERS-CoV) ni ọdun 2012 lati awọn orisun zoonotic.Remdesivir jẹ oogun monophosphoramidate ti C-adenosine nucleoside analogue GS-441524.Ninu awọn sẹẹli ọpọlọ ti o ni idaduro (DBT) ti o ni arun pẹlu MHV, GS-5734 ṣe idiwọ MHV diẹ sii ju GS-441524, pẹlu GS-5734 EC50 ti 0.03 M. Pẹlupẹlu, awọn iye EC50 ti pinnu lẹhin itọju pẹlu GS-441524 ati GS-5734 ni SARS-CoV- ati MERS-CoV-aarun akọkọ eniyan ti o ni arun epithelial cell (HAE).