3-Nitrophthalic Anhydride CAS 641-70-3 Pomalidomide Intermediate Purity>98.0% (HPLC)
Ruifu Kemikali jẹ oluṣakoso asiwaju ti 3-Nitrophthalic Anhydride (CAS: 641-70-3) pẹlu didara to gaju, agbedemeji ti Pomalidomide (CAS: 19171-19-8).Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra 3-Nitrophthalic Anhydride,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 3-Nitrophthalic Anhydride |
| Awọn itumọ ọrọ sisọ | 3-Nitrophthalic Acid Anhydride;4-Nitro-2-Benzofuran-1,3-Dion;4-Nitroisobenzofuran-1,3-Dion;4-Nitro-1,3-isobenzofurandione;Pomalidomide Aimọ́ A |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 641-70-3 |
| Fọọmu Molecular | C8H3NO5 |
| Òṣuwọn Molikula | 193,11 g / mol |
| Ojuami Iyo | 161.0 si 165.0 ℃ |
| Ni imọlara | Ọrinrin Sensitive |
| Omi Solubility | Le Idibajẹ ninu Omi |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Ina Yellow to Yellow Crystal Crystal tabi Crystalline Powder | Ibamu |
| Ojuami Iyo | 161.0 ~ 165.0 ℃ | 163.0 ~ 165.0 ℃ |
| Pipadanu lori Gbigbe | <0.50% | 0.10% |
| Mimọ / Analysis Ọna | > 98.0% (HPLC) | 98.85% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| 1H NMR julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
| Ohun elo | Agbedemeji ti Pomalidomide (CAS: 19171-19-8) | |
Apo:Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Afẹfẹ ifarabalẹ.Jeki apo eiyan naa ni wiwọ ni pipade ati fipamọ sinu itura, gbigbẹ ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Jeki kuro lati oorun;yago fun ina;yago fun ọrinrin.Jeki kuro lati oxidizing òjíṣẹ.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Awọn aami ewu Xi - Irritant
Awọn koodu ewu
36/37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Abo
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S36 - Wọ aṣọ aabo to dara.
S37/39 - Wọ awọn ibọwọ ti o dara ati aabo oju / oju
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Bẹẹni
HS koodu 2917399090
3-Nitrophthalic Anhydride (CAS: 641-70-3) ni a lo gẹgẹbi agbedemeji ti Pomalidomide (CAS: 19171-19-8).Ni Kínní 2013, US FDA fọwọsi Pomalidomide fun itọju ti ọpọ myeloma (MM) ni awọn alaisan ti o ni ilọsiwaju arun lẹhin gbigba awọn itọju ailera akàn miiran.Pomalidomide jẹ afọwọṣe 4-amino ti thalidomide pẹlu agbara imudara ati profaili majele ti ilọsiwaju.Pomalidomide ati thalidomide ṣe awọn ipa wọn nipasẹ iyipada ti ajesara, idinamọ angiogenesis, kikọlu pẹlu egungun / tumo microenvironment, ati idinamọ ti amuaradagba cereblon.Pomalidomide ni agbara ni idinamọ in vitro afikun ni ọpọlọpọ awọn laini sẹẹli MM eniyan, IC50 ~ 10 nM, lakoko ti thalidomide fihan fere ko si idinamọ titi di 100 μM.Ninu awọn awoṣe tumo MM mouse, 50 mg/kg awọn iwọn lilo ojoojumọ ti pomalidomide yorisi idinamọ aami ti idagbasoke tumo lẹhin awọn ọjọ 15 ti itọju ati ipadasẹhin pipe ni awọn ọsẹ 3-6 dipo awọn iṣakoso itọju thalidomide ni iwọn kanna.Pomalidomide ti pese sile nipasẹ isunmọ ti 3-Nitrophthalic Anhydride pẹlu 3-Aminopiperidine-2,6-Dion ti o tẹle pẹlu hydrogenation catalytic ti ẹgbẹ nitro.
