4-Benzyl-2-Hydroxymorpholin-3-ọkan CAS 287930-73-8 Mimọ>99.0% (HPLC) Ile-iṣẹ Agbedemeji Aperepitant
Asiwaju olupese ati olupese
Awọn agbedemeji ti Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-ọkan CAS 287930-73-8
(R) -1- [3,5-Bis (trifluoromethyl) phenyl] ethanol CAS 127852-28-2
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Orukọ Kemikali | 4-Benzyl-2-Hydroxymorpholin-3-ọkan |
Awọn itumọ ọrọ sisọ | 4-Benzyl-2-Hydroxy-Morpholin-3-ọkan;2-Hydroxy-4- (Phenylmethyl) -3-Morpholinone;Ibanujẹ Alaimọ 48;Fosaprepitant Aimọ 23;Agbedemeji agbedemeji Ⅱ |
Nọmba CAS | 287930-73-8 |
NỌMBA CAT | RF2660 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C11H13NO3 |
Òṣuwọn Molikula | 207.23 |
Ojuami Iyo | 134.0 si 138.0 ℃ |
Ojuami farabale | 441,7 ± 45,0 ℃ |
iwuwo | 1,292 ± 0,06 g / cm3 |
Solubility ninu Omi | DMSO (Diẹ), kẹmika (Diẹ, Kikan) |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun to Pa-White Crystal Powder |
Mimọ / Analysis Ọna | > 99.0% (HPLC) |
Ojuami Iyo | 134.0 si 138.0 ℃ |
Omi (nipasẹ Karl Fischer) | <0.50% |
Aloku lori Iginisonu | <0.20% |
Lapapọ Awọn Aimọ | <1.00% |
Proton NMR julọ.Oniranran | Ni ibamu si Eto |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji ti Aprepitant (CAS: 170729-80-3) Oogun Antiemetic |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
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DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
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Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
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Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
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4-Benzyl-2-Hydroxymorpholin-3-ọkan (CAS: 287930-73-8), jẹ agbedemeji ti Aprepitant (CAS: 170729-80-3), ti a lo bi awọn oogun antiemetic.Aprepitant jẹ antagonist olugba neurokinin-1 (NK-1) ati pe o jẹ ti awọn aṣoju itọju ti eebi lakoko kimoterapi ti akàn.Ni akọkọ ni aṣeyọri nipasẹ Merck Company (German).Ni Oṣu Kẹta ọdun 2003, Ile-iṣẹ Ounje ati Oògùn AMẸRIKA fọwọsi rẹ fun lilo ninu itọju eebi kimoterapi.Ọja yii ni isunmọ yiyan giga si awọn eniyan lakoko ti o ni ibatan kekere si serotonin, dopamine ati ibaramu olugba glucocorticoid.Aprepitant, nigba ti a ba ni idapo pẹlu awọn oludena olugba 5-HT3 (gẹgẹbi ondansetron hydrochloride) ati corticosteroid dexamethasone, le tun din cisplatin-induced ńlá ati (tabi) idaduro idaduro.Lilo oogun yii nikan le ni ipa idena diẹ.