4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9 Mimọ>98.5% (HPLC) Lenvatinib Mesylate Agbedemeji Factory
Ipese Kemikali Ruifu Lenvatinib Mesylate Intermediates Pẹlu Iwa mimọ to gaju
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1- (2-Chloro-4-Hydroxyphenyl) -3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dion CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Orukọ Kemikali | 4-Chloro-7-Methoxyquinoline-6-Carboxamide |
Awọn itumọ ọrọ sisọ | 4-Chloro-7-Methoxy-6-Quinolinecarboxamide;Lenvatinib Aimọ 12;Lenvatinib Iwa Aimọ B;Lenvatinib Aimọ LFS-B |
Nọmba CAS | 417721-36-9 |
NỌMBA CAT | RF-PI1971 |
Iṣura Ipo | Ninu Iṣura, Agbara iṣelọpọ 50MT / Ọdun |
Ilana molikula | C11H9ClN2O2 |
Òṣuwọn Molikula | 236.65 |
Ojuami Iyo | > 205 ℃ (oṣu kejila) |
iwuwo | 1.380 ± 0.060 g / cm3 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Pa-White to Light Yellow Powder |
Mimọ / Analysis Ọna | > 98.5% (HPLC) |
Pipadanu lori Gbigbe | <0.50% |
Aloku lori Iginisonu | <0.50% |
Lapapọ Awọn Aimọ | <1.50% |
Proton NMR julọ.Oniranran | Ni ibamu si Eto |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji ti Lenvatinib Mesylate (CAS: 857890-39-2) |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
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4-Chloro-7-Methoxyquinoline-6-Carboxamide (CAS: 417721-36-9) ti wa ni lilo julọ bi agbedemeji ti Lenvatinib Mesylate (CAS: 857890-39-2).Idagbasoke nipasẹ Eisai Inc., lenvatinib mesylate jẹ olutọpa ti iṣan ti iṣan ti iṣan ti iṣan (VEGF) ti o ni iṣẹ-ṣiṣe lodi si VEGF subtypes 1, 2, ati 3 ati pe FDA fọwọsi ni 2015 fun itọju ti akàn tairodu ti o yatọ ti o jẹ boya ni agbegbe. loorekoore, metastatic, tabi ilọsiwaju ati pe ko dahun si itọju iodine ipanilara.Ni Oṣu Karun ọdun 2016, FDA fọwọsi oogun naa gẹgẹbi apapọ itọju ailera pẹlu everolimus fun itọju ti carcinoma sẹẹli kidirin to ti ni ilọsiwaju.Nitoripe VEGF (ati fibroblast idagba ifosiwewe awọn olugba, ti a mọ ni FGFRs) ni a ro pe o ṣe ipa kan ninu awọn ipa ọna ifihan agbara ẹjẹ, VEGF2R ati FGFR idinamọ ni a ro pe awọn ilana ti o wa lẹhin ipa akọkọ ti lenvatinib mesylate, eyiti o jẹ haipatensonu.
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