5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Ipese Vonoprazan Fumarate ati ibatan Intermediate
5- (2-Fluorophenyl) pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl kiloraidi CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Orukọ Kemikali | 5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde |
| Awọn itumọ ọrọ sisọ | Vonoprazan Fumarate (TAK-438) Agbedemeji 3 |
| Nọmba CAS | 881674-56-2 |
| NỌMBA CAT | RF-PI330 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C11H8FNO |
| Òṣuwọn Molikula | 189.19 |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Yellow to Brown Powder |
| Ojuami Iyo | 122.0 ~ 131.0 ℃ |
| Idanimọ: RT(HPLC) | Ṣe ibamu pẹlu Iwọn Itọkasi |
| Isonu Lori Gbigbe | ≤0.50% |
| Aloku Lori iginisonu | ≤0.50% |
| Awọn nkan ti o jọmọ | |
| Mimo | ≥99.0% |
| Eyikeyi Nikan Aimọ | ≤0.50% |
| Lapapọ Awọn Aimọ | ≤1.0% |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Agbedemeji ti Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
5- (2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) ṣe bi reagent ninu igbaradi sintetiki ti awọn itọsẹ pyrrole aramada bi potasiomu-idije acid blocker (P-CAB).5- (2-Fluorophenyl) pyrrole-3-Carboxaldehyde jẹ agbedemeji ti Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), ṣe awari ati idagbasoke nipasẹ Takeda ati Otsuka, ti fọwọsi nipasẹ PMDA ti Japan ni Oṣu Kejila ọdun 2014, ati pe o jẹ itọkasi fun itọju ọgbẹ inu, ọgbẹ duodenal ati reflux esophagitis.Vonoprazan fumarate ni ilana ti aramada ti iṣe ti a pe ni awọn blockers acid competitive potasiomu, eyiti o ṣe idiwọ idinamọ ti awọn ions potasiomu si H +, K +-ATPase (ti a tun mọ ni fifa proton) ni ipele ikẹhin ti yomijade acid inu ninu awọn sẹẹli ti inu.Vonoprazan ko ṣe idiwọ iṣẹ Na +, K + -ATPase paapaa ni awọn ifọkansi awọn akoko 500 ti o ga ju ti awọn iye IC50 wọn lodi si iṣẹ H +, K + -ATPase inu.Pẹlupẹlu, oogun naa ko ni ipa nipasẹ ipo aṣiri ikun, ko dabi awọn PPI.
