7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3 Purity>99.0% (HPLC) Afatinib Dimaleate Agbedemeji Factory Aworan Ifihan

7-Fluoro-6-Nitroquinazolin-4(1H)-ọkan CAS 162012-69-3 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Apejuwe kukuru:

Orukọ Kemikali: 7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan

CAS: 162012-69-3

Mimọ:> 99.0% (HPLC)

Yellow to Reddish Yellow Crystal tabi Lulú

Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

Didara to gaju, iṣelọpọ Iṣowo

E-Mail: alvin@ruifuchem.com

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ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
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(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan
Awọn itumọ ọrọ sisọ	7-Fluoro-6-Nitroquinazolin-4 (3H) -ọkan;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-ọkan
Nọmba CAS	162012-69-3
NỌMBA CAT	RF-PI2025
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Ilana molikula	C8H4FN3O3
Òṣuwọn Molikula	209.13
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Yellow to Reddish Yellow Crystal tabi Lulú
1 H NMR julọ.Oniranran	Ni ibamu Pẹlu Be
Mimọ / Analysis Ọna	> 99.0% (HPLC)
Pipadanu lori Gbigbe	<0.50%
Lapapọ Awọn Aimọ	<1.00%
Proton NMR julọ.Oniranran	Ni ibamu si Eto
Igbeyewo Standard	Standard Enterprise
Lilo	Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan (CAS: 162012-69-3) jẹ agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7).Afatinib jẹ idile ErbB ti ko le yipada ti awọn oludena ti o dinku gbigbe alaye ati dina awọn ipa ọna pataki ti o ni ipa ninu idagbasoke sẹẹli alakan ati pipin.Nitori ẹrọ gbigbe alaye ti idile ErbB le ṣe okunfa nipasẹ ọpọlọpọ awọn homodimers ati heterodimers, idinamọ nigbakanna ti awọn ọmọ ẹgbẹ ẹbi ErbB pupọ (bii EGFR, HER2, ErbB3 ati ErbB4) le ṣe idiwọ gbigbejade alaye isale.Afatinib jẹ oogun ti a fọwọsi fun itọju ti kii-kekere sẹẹli ẹdọfóró carcinoma (NSCLC), ti o dagbasoke nipasẹ Boehringer Ingelheim.O ṣe bi oludena angiokinase.Gẹgẹbi lapatinib ati neratinib, afatinib jẹ inhibitor tyrosine kinase (TKI) ti o tun ṣe idiwọ idilọwọ awọn olugba idagba idagba eniyan epidermal 2 (Her2) ati epidermal growth factor receptor (EGFR) kinases.Afatinib ko ṣiṣẹ nikan ni ilodi si awọn iyipada EGFR ti a fojusi nipasẹ iran akọkọ TKIs likeerlotinib tabi gefitinib, ṣugbọn tun lodi si awọn ti ko ni ifarabalẹ si awọn itọju boṣewa wọnyi.Nitori iṣẹ ṣiṣe afikun rẹ lodi si Her2, o ti wa ni iwadii fun akàn igbaya bi daradara bi EGFR miiran ati awọn aarun itọka Her2.