Afatinib CAS 439081-18-2 Mimọ> 99.5% (HPLC) Aworan Ifihan Factory

Afatinib CAS 439081-18-2 Purity>99.5% (HPLC) Factory

Apejuwe kukuru:

Orukọ Kemikali: Afatirib

Synonyms: BIBW2992

CAS: 439081-18-2

Mimọ:> 99.5% (HPLC)

Irisi: Pa-White Powder

E-Mail: alvin@ruifuchem.com

Fi imeeli ranṣẹ si wa

Alaye ọja

Jẹmọ Products

ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	Afatinib
Awọn itumọ ọrọ sisọ	BIBW2992;BIBW-2992;BIBW2992 Ipilẹ Ọfẹ;Tomtovok;(S, E) - N- (4- (3-Chloro-4-Fluorophenylamino) -7- (Tetrahydrofuran-3-yloxy) quinazolin-6-yl) -4- (Dimethylamino) ṣugbọn-2-Enamide
Nọmba CAS	439081-18-2
NỌMBA CAT	RF-PI2033
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular	C24H25ClFN5O3
Òṣuwọn Molikula	485.94
Solubility	Tiotuka ni DMSO
iwuwo	1.380
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Pa-White Powder
Idanimọ	HPLC, NMR
Mimọ / Analysis Ọna	> 99.5% (HPLC)
Ojuami Iyo	100.0 ~ 102.0 ℃
Pipadanu lori Gbigbe	<0.50%
Aloku lori Iginisonu	<0.20%
Lapapọ Awọn Aimọ	<0.50%
Awọn irin Heavy	≤20ppm
NMR julọ.Oniranran	Ni ibamu si Eto
Igbeyewo Standard	Standard Enterprise
Igbesi aye selifu	Awọn oṣu 24 ti o ba fipamọ daradara
Lilo	API;Afatinib;Afatinib Dimaleate;NSCLC

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

Afatinib, ti a tun mọ ni BIW-2992, (CAS: 439081-18-2) jẹ agbara-iran keji ti o ni agbara ati inhibitor meji ti a ko le yipada ti olugba idagba idagbasoke ti epidermal (EGFR) ati awọn olugba idagba idagba eniyan epidermal 2 (HER2) tyrosine kinase, ni idagbasoke nipasẹ Boehringer Ingelheim, Jẹmánì.O lagbara lati ṣe idiwọ iṣẹ-ṣiṣe ti tyrosine kinase ni aiṣe-padabọ nipasẹ ṣiṣe iṣesi Michael pẹlu ẹgbẹ thiol ti cysteine ni ipo 797 ti EGFR.Ni Oṣu Keje Ọjọ 12, Ọdun 2013, o di oogun tuntun fun akàn ẹdọfóró sẹẹli kekere ti a fọwọsi nipasẹ FDA AMẸRIKA labẹ orukọ iṣowo Gilotrif.Oogun yii jẹ tabulẹti kan.O ti wa ni lilo fun awọn itọju ti awọn alaisan ayẹwo pẹlu metastatic ti kii-kekere cell ẹdọfóró akàn (NSCLC) pẹlu awọn isonu ti 19th exon tabi L858R iyipada ni 21th exon ti tumo epidermal idagbasoke ifosiwewe receptor (EGFR) timo nipa lilo ohun elo ti a fọwọsi. nipasẹ FDA.Oogun naa tun munadoko ninu itọju awọn alaisan HER2-rere pẹlu akàn igbaya to ti ni ilọsiwaju.Afatinib jẹ ti kilasi awọn oogun ti a mọ si awọn inhibitors tyrosine kinase.Awọn inhibitors Tyrosine kinase jẹ apẹrẹ lati dènà iṣẹ ti enzymu kan pato ti a pe ni tyrosine kinase.Enzymu yii ṣe ipa nla ninu iṣẹ ti awọn sẹẹli, ati pe o nṣiṣe lọwọ ni igbega idagbasoke idagbasoke ati ilọsiwaju.Afatinib n ṣiṣẹ lati ṣe idiwọ iṣẹ ti awọn iru meji ti awọn kinases tyrosine: olugba idagba ifosiwewe ti epidermal (EGFR) ati Her2, eyiti o jẹ “ifihan ju” nipasẹ ọpọlọpọ awọn oriṣi ti akàn.Nipa didi iṣẹ ti awọn kinases tyrosine wọnyi, Afatinib le ṣe idiwọ awọn sẹẹli alakan lati pin ati dagba.