Afatinib Dimaleate CAS 850140-73-7 Purity>99.5% (HPLC) API

Apejuwe kukuru:

Orukọ Kemikali: Afatinib Dimaleate

Synonyms: BIBW2992 Dimaleate

CAS: 850140-73-7

Mimọ:> 99.0% (HPLC)

Irisi: Funfun si Paa-White Powder

API Didara Giga, Iṣelọpọ Iṣowo

E-Mail: alvin@ruifuchem.com

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Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	Afatinib Dimaleate
Awọn itumọ ọrọ sisọ	BIBW2992 Dimaleate;(S, E) -N- (4- (3-Chloro-4-Fluorophenylamino) -7- (Tetrahydrofuran-3-yloxy) quinazolin-6-yl) -4- (dimethylamino) ṣugbọn-2-Enamide Dimaleate
Nọmba CAS	618-89-3
NỌMBA CAT	RF-PI2032
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular	C32H33ClFN5O11
Òṣuwọn Molikula	718.08
Ifamọ	Ọrinrin Sensitive
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun to Pa-White Powder
Mimọ / Analysis Ọna	> 99.5% (HPLC)
Pipadanu lori Gbigbe	<0.50%
Aloku lori Iginisonu	<0.10%
O pọju Nikan Aimọ	<0.30%
Lapapọ Awọn Aimọ	<0.50%
Awọn irin Heavy (gẹgẹbi Pb)	≤20ppm
Infurarẹẹdi julọ.Oniranran	Ni ibamu si Eto
NMR	Ni ibamu si Eto
Igbeyewo Standard	Standard Enterprise
Igbesi aye selifu	Awọn oṣu 24 ti o ba fipamọ daradara
Lilo	API

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

Afatinib Dimaleate (CAS: 850140-73-7), iyọ dimaleate ti afanitib, jẹ aṣoju antineoplastic ti o wa ni ẹnu.Afatinib Dimaleate jẹ inhibitor idile EGFR ti ko le yipada pẹlu IC50s ti 0.5 nM, 0.4 nM, 10 nM ati 14 nM fun EGFRwt, EGFRL858R, EGFRL858R/T790M ati HER2, lẹsẹsẹ.Afatinib Dimaleate jẹ itọkasi fun itọju laini akọkọ ti awọn alaisan ti o ni akàn ẹdọfóró ti kii-kekere sẹẹli (NSCLC) ti awọn èèmọ wọn ni olugba idagba ifosiwewe idagba epidermal (EGFR) exon 19 awọn piparẹ tabi exon 21 (L858R) awọn iyipada iyipada bi a ti rii nipasẹ FDA- igbeyewo ti a fọwọsi.Ni iṣaaju, itọju boṣewa pẹlu ilana ilana chemotherapy ti o da lori Platinum ni a gba pe itọju laini akọkọ boṣewa fun gbogbo awọn alaisan ti o ni NSCLC.Bibẹẹkọ, ẹri ti n yọ jade ti ṣe idanimọ awọn agbeka-ipin ninu eyiti itọju ailera ti a fojusi jẹ doko diẹ sii, ti o yori si idagbasoke awọn oogun-iyipada-pato.Afatinib Dimaleate ti ni idagbasoke nipasẹ Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate ti fọwọsi nipasẹ FDA ni ọdun 2013 gẹgẹbi oogun orukan labẹ orukọ iṣowo Gilotrif.Afatinib Dimaleate jẹ iṣelọpọ kemikali nipa lilo awọn ọna boṣewa.Afatinib Dimaleateko ṣiṣẹ nikan ni ilodi si awọn iyipada EGFR ti o ni idojukọ nipasẹ awọn iran akọkọ TKIs bi erlotinib tabi gefitinib, ṣugbọn tun lodi si awọn iyipada bii T790M eyiti ko ni ifarabalẹ si awọn itọju boṣewa wọnyi.Nitori iṣẹ ṣiṣe afikun rẹ lodi si Her2, o ti wa ni iwadii fun akàn igbaya bi daradara bi EGFR miiran ati awọn aarun itọka Her2.