Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity>99.0% (HPLC) Aworan Ifihan Factory

Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity>99.0% (HPLC) Factory

Apejuwe kukuru:

Orukọ Kemikali: (S) -N4- (3-Chloro-4-Fluorophenyl) -7-( (Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine

CAS: 314771-76-1

Mimọ:> 99.0% (HPLC)

Irisi: Imọlẹ Yellow to Yellow Powder

Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Fi imeeli ranṣẹ si wa

Alaye ọja

Jẹmọ Products

ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine
Awọn itumọ ọrọ sisọ	N4- (3-Chloro-4-Fluorophenyl) -7-[[(3S) -Tetrahydro-3-Furanyl] oxy] -4,6-Quinazolinediamine;Afatinib Aimọ́ B;Afatinib-des (4-Dimethylamino-2-en-1-oxo)butyl;Des (4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Nọmba CAS	314771-76-1
NỌMBA CAT	RF-PI2028
Iṣura Ipo	Ninu Iṣura, Agbara iṣelọpọ 100MT / Ọdun
Ilana molikula	C18H16ClFN4O2
Òṣuwọn Molikula	374.8
Ojuami farabale	559,0 ± 50,0 ℃
iwuwo	1,473 ± 0,060 g / cm3
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Ina Yellow to Yellow Powder
Idanimọ	Akoko Idaduro ti tente oke akọkọ ni HPLC yẹ ki o baamu si Iwọnwọn
Mimọ / Analysis Ọna	> 99.0% (HPLC)
Pipadanu lori Gbigbe	<0.50%
Aloku lori Iginisonu	<0.20%
Aimọ Kanṣoṣo	<0.50%
Lapapọ Awọn Aimọ	<1.00%
Awọn irin Heavy (gẹgẹbi Pb)	≤20ppm
Igbeyewo Standard	Standard Enterprise
Lilo	Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine (CAS: 314771-76-1) jẹ agbedemeji ti Afatinib Dimaleate. (CAS: 850140-73-7).Afatinib jẹ agbara-iran keji ti o lagbara ati inhibitor meji ti ko ni iyipada ti olugba idagba idagbasoke ti epidermal (EGFR) ati awọn olugba idagbasoke idagbasoke ti eniyan 2 (HER2) tyrosine kinase, ti o ni idagbasoke nipasẹ Boehringer Ingelheim, Germany.O lagbara lati ṣe idiwọ iṣẹ-ṣiṣe ti tyrosine kinase ni aiṣe-padabọ nipasẹ ṣiṣe iṣesi Michael pẹlu ẹgbẹ thiol ti cysteine ni ipo 797 ti EGFR.Išẹ: 1. Bi Lapatinib ati Neratinib, Afatinib jẹ amuaradagba kinase inhibitor ti o tun ṣe aiṣedeede ti o ṣe idiwọ ti o ni idaabobo ti o pọju ti eniyan 2 (Her2) ati epidermal growth factor receptor (EGFR) kinases.2. Afatinib ko ṣiṣẹ nikan ni ilodi si awọn iyipada EGFR ti a fojusi nipasẹ iran akọkọ TKIs bi erlotinib tabi gefitinib, ṣugbọn tun lodi si awọn iyipada bii T790M eyiti ko ni ifarabalẹ si awọn itọju boṣewa wọnyi.Nitori iṣẹ ṣiṣe afikun rẹ lodi si Her2, o ti wa ni iwadii fun akàn igbaya bi daradara bi EGFR miiran ati awọn aarun itọka Her2.3. Afatinib jẹ oogun kan fun itọju laini akọkọ ti awọn alaisan ti o ni awọn iru iyasọtọ ti metastatic (EGFR mutation positive) ti kii-kekere sẹẹli ẹdọfóró carcinoma (NSCLC).O ṣe bi onidalẹkun covalent ti ko le yipada ti olugba tyrosine kinases olugba idagba ifosiwewe epidermal (EGFR) ati erbB-2 (HER2).