Anastrozole CAS 120511-73-1 API Factory High Quality
Ipese Olupese pẹlu Iwa-mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Anastrozole
CAS: 120511-73-1
Oruko | Anastrozole |
Awọn itumọ ọrọ sisọ | Arimidex;α, α, α', α'-Tetramethyl-5- (1H-1,2,4-triazol-1-ylmethyl) -1,3-benzenediacetonitrile |
Nọmba CAS | 120511-73-1 |
NỌMBA CAT | RF-API74 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C17H19N5 |
Òṣuwọn Molikula | 293.37 |
Solubility | Soluble ni DMSO ati Ethanol |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun lati Pa-White Crystalline Powder |
Idanimọ A | IR/MS Ni ibamu pẹlu boṣewa itọkasi |
Idanimọ B | HPLC ati apẹrẹ ti o ga julọ: Ni ibamu si itọkasi |
Ojuami Iyo | 81.0 ~ 84.0 ℃ |
Akoonu Omi (nipasẹ KF) | ≤0.30% |
Aloku lori Iginisonu | ≤0.10% |
Pipadanu lori Gbigbe | ≤0.50% |
Awọn irin Heavy | ≤10ppm |
Awọn nkan ti o jọmọ | |
Aimọ́ A | ≤0.10% |
Aimọ́ B | ≤0.20% |
Iwa aimọ C | ≤0.20% |
Àìmọ́ D | ≤0.10% |
Aimọ́ E | ≤0.10% |
Nikan Miiran Aimọ | ≤0.10% |
Lapapọ Awọn Aimọ | ≤0.50% |
Awọn ohun elo ti o ku | |
Cyclohexane | ≤0.30% |
Ethyl acetate | ≤0.50% |
Ayẹwo | 98.0% ~ 102.0% (lori ipilẹ ti o gbẹ) |
Igbesi aye selifu | 24 osu |
Igbeyewo Standard | Standard Enterprise;United States Pharmacopoeia (USP) Standard |
Lilo | Itoju fun Breast Cancer |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
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Anastrozole (CAS 120511-73-1), jẹ ti kii-sitẹriọdu, iran kẹta achiral triazole itọsẹ fun tita bi ARIMIDEX® nipasẹ AstraZeneca Pharmaceuticals LP1.O jẹ ọkan ninu awọn oludena aromatase iran-kẹta ti o jẹ idije ti o ga julọ ati ti o yan ti aromatase, nitorina ni idinamọ iyipada ti testosterone sinu estradiol ati androstenedione sinu estrone.Idinamọ ti enzymu aromatase waye ni pataki nipasẹ isọdọkan ifigagbaga ti aromatase si ẹgbẹ hemegroup ti cytochrome P450, idinku biosynthesis estrogen ni awọn sẹẹli agbeegbe ti ara ati ninu ọmu.
Anastrozole jẹ itọju ti o farada ni gbogbogbo fun alakan igbaya ipele-ibẹrẹ.Gẹgẹbi awọn inhibitors aromatase miiran, ipa buburu ti o ṣe pataki julọ jẹ ewu ti o pọ si ti awọn fifọ egungun, eyiti o jẹ ihamọ fun anastrozole si akoko itọju naa.O ti iwa ni majele ti ìwọnba nigba akawe pẹlu kimoterapi;sibẹsibẹ, o ti ṣe akiyesi pe diẹ sii awọn alaisan ti a tọju pẹlu anastrozole ti rojọ ti awọn aami aisan apapọ ju ti a ti ṣe yẹ lọ, paapaa lile oni-nọmba ti o jọra si ti arthritis rheumatoid.Diẹ ninu awọn idanwo ile-iwosan ti anastrozole fun awọn obinrin postmenopausal ti o ni ọgbẹ igbaya ni Yuroopu ati awọn ipinlẹ Amẹrika royin awọn rudurudu ti iṣan bi awọn iṣẹlẹ buburu.Anastrozole (Arimidex®) jẹ inhibitor aromatase ti a fọwọsi ni EU, AMẸRIKA ati ni awọn orilẹ-ede miiran ni agbaye fun lilo bi itọju adjuvant ni awọn obinrin postmenopausal ti o ni ibẹrẹ-ipele, akàn igbaya receptor-positive hormone.O tun fọwọsi ni EU ati awọn orilẹ-ede miiran ni agbaye fun itọju ajẹmọra ti o tẹsiwaju ninu awọn obinrin ti o ti ni ọdun 2-3 tẹlẹ ti itọju tamoxifen adjuvant fun akàn igbaya.
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