Apixaban CAS 503612-47-3 Mimọ ≥99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Apixaban (CAS: 503612-47-3) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Apixaban,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Apixaban |
| Awọn itumọ ọrọ sisọ | 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6- [4- (2-oxo-1-piperidinyl) phenyl] -1H-pyrazolo [3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 503612-47-3 |
| Fọọmu Molecular | C25H25N5O4 |
| Òṣuwọn Molikula | 459,51 g / mol |
| Ojuami Iyo | 235.0 ~ 238.0 ℃ |
| iwuwo | 1.42 |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | API |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Funfun lati Pa-White Crystalline Powder | Ibamu |
| Pipadanu lori Gbigbe | ≤0.50% | 0.10% |
| Aloku lori Iginisonu | ≤0.10% | 0.08% |
| Awọn irin Heavy (gẹgẹbi Pb) | ≤20ppm | Ibamu |
| Awọn nkan ti o jọmọ | ||
| Eyikeyi Nikan Aimọ | ≤0.50% | Ibamu |
| Lapapọ Awọn Aimọ | ≤0.50% | Ibamu |
| Mimọ / Analysis Ọna | ≥99.5% (HPLC) | 99.9% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| 1 H NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Ko si ọja naa ti yoo pese si awọn orilẹ-ede eyiti eyi le ni ilodi si pẹlu awọn itọsi ti o wa.Sibẹsibẹ ojuse ikẹhin wa pẹlu ẹniti o ra.
Fun lilo iwadii imọ-jinlẹ nikan, kii ṣe fun eyikeyi idi iṣowo, kii ṣe fun eniyan tabi lilo iwadii aisan.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Apixaban (CAS: 503612-47-3) jẹ fọọmu tuntun ti oogun ajẹsara ẹnu ti o ni idagbasoke nipasẹ Bristol Myers Squibb ati Pfizer.O jẹ fọọmu tuntun ti inhibitor Xa ifosiwewe oral, ati pe orukọ iṣowo rẹ jẹ Eliquis.A lo Apixaban lati tọju awọn alaisan agbalagba ti o gba ibadi yiyan tabi iṣẹ abẹ rirọpo orokun lati ṣe idiwọ iṣọn-ẹjẹ iṣọn-ẹjẹ (VTE)
Apixaban (CAS: 503612-47-3) jẹ oludena ifosiwewe Xa ifosiwewe ti o yan ati pe o le ṣe idiwọ iran thrombin ati thrombosis.
Apixaban (CAS: 503612-47-3) jẹ anticoagulant tuntun kẹta ti ẹnu lati lọ si tita, ni atẹle dabigatran ati rivaroxaban, ati pe o ti fọwọsi tẹlẹ ni Yuroopu fun idilọwọ iṣọn-ẹjẹ iṣọn-ẹjẹ ni awọn alaisan ti o ngba ibadi yiyan tabi iṣẹ abẹ rirọpo orokun.Ninu awọn oogun anticoagulants mẹta mẹta wọnyi ti a fọwọsi ni Yuroopu, ni akawe si itọju idilọwọ lọwọlọwọ lọwọlọwọ lodi si thromboembolism iṣọn-ẹjẹ, enoxaparin, rivaroxaban bori ninu idanwo igbasilẹ, ati apixaban bori ninu idanwo ilosiwaju.Awọn ipa alumoni ti Rivaroxaban ga diẹ, ṣugbọn o fa ẹjẹ ti o lagbara ju apixaban lọ.Awọn oniwadi ṣe afihan awọn iyatọ wọnyi si akoko oogun, bi a ti mu rivaroxaban ni awọn wakati 6-8 lẹhin iṣẹ abẹ ni idanwo igbasilẹ, lakoko ti a ti lo apixaban ni awọn wakati 18 lẹhin iṣẹ abẹ ni iṣaju iṣaju.Awọn oogun wọnyi ni ipa imularada to dara julọ nigba lilo isunmọ akoko iṣẹ abẹ, ṣugbọn tun ni eewu ẹjẹ ti o pọ si.Iwadi ile-iwosan fihan pe ni akawe si abẹrẹ subdermal ojoojumọ ti 40mg enoxaparin, 2 oral 2.5mg dosages ti apixaban ni awọn ipa idena ti o dara julọ si iṣọn-ẹjẹ iṣọn-ẹjẹ ni atẹle ibadi tabi iṣẹ abẹ rirọpo orokun ati pe ko mu eewu ẹjẹ pọ si.
Apixaban (CAS: 503612-47-3) jẹ oriṣi tuntun ti inhibitor Xa ifosiwewe oral ti o ni idagbasoke nipasẹ Bristol-Myers Squibb ati Pfizer.Orukọ iṣowo jẹ eratol, eyiti o jẹ iru tuntun ti anticoagulant ẹnu.Nipa idinamọ ifosiwewe coagulation pataki Xa, apixaban le ṣe idiwọ iṣelọpọ thrombin ati thrombosis.Ni Oṣu Kẹrin Ọjọ 26, Ọdun 2007, Bristol-Myers Squibb darapọ mọ ọwọ pẹlu Pfizer lati kede ifowosowopo ni idagbasoke apixaban anticoagulant ti ẹnu tuntun ti Bristol-Myers Squibb bi yiyan igbegasoke si warfarin.Gẹgẹbi adehun ifowosowopo, Pfizer yoo san isanwo ilosiwaju ti US $ 0.25 bilionu si Bristol-Myers Squibb lati jẹri 60% ti idiyele idagbasoke lapapọ ti apixaban anticoagulant (lati ṣe imuse lati Oṣu Kini Ọjọ 1, Ọdun 2007), lakoko ti Bristol-Myers Squibb yoo jẹri 40% to ku, nitorinaa gba ẹtọ lati ṣe idagbasoke apapọ ati ta oogun naa.Ni Oṣu Karun ọdun 2011, apixaban ni akọkọ lati fọwọsi idena ti iṣọn-ẹjẹ iṣọn-ẹjẹ ni awọn alaisan agbalagba ti o gba ibadi yiyan tabi iṣẹ abẹ rirọpo orokun ni awọn orilẹ-ede 27 EU, Iceland ati Norway.Ni Oṣu kọkanla ọjọ 20, Ọdun 2012, Igbimọ Yuroopu fọwọsi Ererto (apixaban) fun idena ikọlu ati iṣọn-ẹjẹ eto ni awọn alaisan agbalagba ti o ni fibrillation atrial ti kii-valvular (NVAF) pẹlu ọkan tabi diẹ sii awọn okunfa ewu.Lẹhinna, Ile-iṣẹ Ounje ati Oògùn ti Ilu Kanada, Japan, ati AMẸRIKA FDA fọwọsi Ererto?(apixaban) fun idena ikọlu ati iṣọn-ẹjẹ eto ni awọn alaisan agbalagba ti o ni fibrillation atrial ti kii-valvular (NVAF) pẹlu ọkan tabi diẹ sii awọn okunfa ewu.Ni Oṣu Kẹrin Ọjọ 12, Ọdun 2013, oogun anticoagulant tuntun Eloto (ELIQUIS)(apixaban) ti o dagbasoke ni apapọ nipasẹ Bristol-Myers Squibb ati Pfizer ti kede ni ifowosi lati ṣe atokọ ni Ilu China.Ererto jẹ oludena ẹnu ara aramada Xa inunibini fun idena ti iṣọn-ẹjẹ iṣọn-ẹjẹ (VTE) ninu awọn alaisan agbalagba ti o ngba ibadi yiyan tabi rirọpo orokun.Atokọ rẹ n pese aṣayan tuntun ti o ni aabo ati imunadoko fun anticoagulation ile-iwosan lẹhin iṣẹ abẹ orthopedic, ati mu awọn iroyin ti o dara wa si awọn alaisan Kannada ti o gba aropo yiyan ibadi/orokun.Awọn ijinlẹ ile-iwosan ti jẹrisi pe ni akawe pẹlu 40mg enoxaparin lẹẹkan ni ọjọ kan, awọn akoko 2 ni ọjọ kan iṣakoso ẹnu ti eratol?(apixaban) 2.5mg jẹ diẹ munadoko fun idilọwọ iṣọn-ẹjẹ iṣọn-ẹjẹ lẹhin ibadi tabi iṣẹ abẹ rirọpo orokun, ati pe ko mu eewu ẹjẹ pọ si.Nọmba 1 fihan awọn tabulẹti Elotoapixaban ti a ṣe nipasẹ Bristol-Myers Squibb ati Pfizer.
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