Atazanavir CAS 198904-31-3 Mimọ ≥99.0% API Factory Anti-HIV HIV-1 Inhibitor Protease

Atazanavir (CAS 198904-31-3) jẹ antiretroviral, aramada ati oogun azapeptide ti o lagbara ti kilasi inhibitor protease (PI).O ti ta labẹ orukọ iṣowo Reyataz.Gẹgẹbi awọn antiretrovirals miiran, a lo lati ṣe itọju ikolu ti ọlọjẹ ajẹsara ajẹsara eniyan iru 1 (HIV-1) enzymu protease pẹlu idinamọ igbagbogbo Ki ti 66 nmol/L ati pe o tun ṣe idiwọ atunda gbogun ti HIV-1 pẹlu 50% ifọkansi ti o munadoko EC50 lati ọdọ. 2.6 si 5.3 nmol/L.Atazanavir sopọ mọ HIV-1 protease idilọwọ awọn cleavage ti gag ati gag-pol polyproteins, eyi ti àbábọrẹ ni dida awọn virions immature ni HIV-1-ikolu awọn sẹẹli.Atazanavir ni eto kemikali alamimọ C-2 ti o yatọ ati agbara gbogbogbo antiretroviral ni ọpọlọpọ awọn igara HIV ni akawe si awọn inhibitors protease miiran, pẹlu Indinavir, Nelfinavir, Ritonavir, Saquinavir ati Amprenavir.Atazanavir ṣe iyatọ si awọn PI miiran ni pe o le fun ni ni ẹẹkan-ojoojumọ ati pe o ni awọn ipa ti o kere si lori profaili ọra alaisan.Gẹgẹbi awọn inhibitors protease miiran, a lo nikan ni apapo pẹlu awọn oogun HIV miiran.Atazanavir jẹ aramada azapeptide HIV protease inhibitor.Antiviral.O ti wa ni mu nipa ẹnu lẹẹkan ọjọ kan.