Atazanavir Sulfate CAS 229975-97-7 Mimọ ≥99.0% API Factory Anti-HIV HIV-1 Inhibitor Protease
Ipese pẹlu Iwa mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Atazanavir Sulfate
CAS: 229975-97-7
HIV-1 Protease Inhibitor
API Didara Giga, Iṣelọpọ Iṣowo
Orukọ Kemikali | Sulfate Atazanavir |
Awọn itumọ ọrọ sisọ | BMS-232632 imi-ọjọ |
Nọmba CAS | 229975-97-7 |
NỌMBA CAT | RF-API71 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C38H52N6O7.H2SO4 |
Òṣuwọn Molikula | 802.93 |
Ojuami Iyo | 195.0 ~ 198.0 ℃ |
Solubility | Insoluble in Water, Soluble in DMSO |
Ibi ipamọ igba pipẹ | Tọju Igba pipẹ ni -20 ℃ |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Pa-White Powder |
Sulfate | 12.0 ~ 12.5% |
Pipadanu lori Gbigbe | ≤0.50% |
Aloku lori Iginisonu | ≤0.10% |
Awọn irin Heavy | ≤20ppm |
Aimọ Kanṣoṣo | ≤0.30% |
Lapapọ Awọn Aimọ | ≤1.0% |
Mimọ / Analysis Ọna | ≥99.0% (HPLC) |
pH | 5.0 ~ 8.0 |
Igbeyewo Standard | Standard Enterprise |
Lilo | HIV-1 Protease inhibitor Anti-HIV |
Package: Igo, apo apamọwọ Aluminiomu, Ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Atazanavir Sulfate (BMS-232632 Sulfate) (CAS: 229975-97-7) jẹ fọọmu iyọ sulfate ti atazanavir ti o jẹ oludena protease HIV-1 ti o yan pupọ, jẹ oludena protease akọkọ ti a fọwọsi fun iṣakoso lẹẹkan lojoojumọ.Sulfate Atazanavir jẹ sobusitireti ati inhibitor ti CYP3A4, ati inhibitor ati inducer ti P-glycoprotein (P-gp).Atazanavir Sulfate tun jẹ inhibitor SARS-CoV 3CLpro pẹlu IC50 ti 3.49 μM.Atazanavir Sulfate jẹ azapeptide ati inhibitor HIV-protease ti o lo ninu itọju awọn akoran HIV ati Arun Kogboogun Eedi ni apapo pẹlu Awọn Aṣoju Anti-HIV miiran, ti ni idagbasoke ati ifilọlẹ nipasẹ Bristol-Myers Squibb (BMS), labẹ iwe-aṣẹ agbaye lati Novartis, fun itọju ti kokoro HIV.A ṣe ifilọlẹ Atazanavir ni AMẸRIKA bi Reyataz™ ni Oṣu Keje ọdun 2003. Antiviral.Atazanavir ti fihan pe o ni agbara diẹ sii ju marun ti a fọwọsi lọwọlọwọ awọn inhibitors protease HIV-1.Atazanavir yiyan ṣe idiwọ sisẹ-pato ọlọjẹ ti gbogun ti Gag ati Gag-Pol polyproteins ninu awọn sẹẹli ti o ni kokoro HIV-1 nipa didi si aaye ti nṣiṣe lọwọ ti protease HIV-1, nitorinaa idilọwọ dida awọn virions ogbo.Atazanavir ko ṣiṣẹ lodi si HIV-2.