Baloxavir Marboxil CAS 1985606-14-1 API Factory Didara Giga

Apejuwe kukuru:

Orukọ Kemikali: Baloxavir Marboxil

CAS: 1985606-14-1

Irisi: Funfun si Paa-White Powder

Ayẹwo: 98.0% ~ 102.0%

Ni itọju ti aarun ayọkẹlẹ A ati aarun ayọkẹlẹ B

Olubasọrọ: Dokita Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Apejuwe:

Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Baloxavir Marboxil (CAS: 1985606-14-1) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Kemikali Properties:

Orukọ Kemikali	Baloxavir Marboxil
Awọn itumọ ọrọ sisọ	BXM;S-033188
Nọmba CAS	1985606-14-1
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram
Fọọmu Molecular	C27H23F2N3O7S
Òṣuwọn Molikula	571.55
iwuwo	1,57 ± 0,10 g / cm3
Solubility	Tiotuka ni DMSO
Ibi ipamọ igba pipẹ	Tọju Igba pipẹ ni -20 ℃
COA & MSDS	Wa
Ipilẹṣẹ	Shanghai, China
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun to Pa-White Powder
Idanimọ	Awọn julọ.Oniranran IR ni ibamu si boṣewa itọkasi Akoko idaduro ni ibamu si boṣewa itọkasi
Akoonu Omi (nipasẹ KF)	≤1.0%
Pipadanu lori Gbigbe	≤1.0%
Aloku lori Iginisonu	≤0.50%
Awọn irin Heavy	≤20ppm
Awọn nkan ti o jọmọ
O pọju Aimọ Olukuluku	≤0.50%
Lapapọ Awọn Aimọ	≤1.0%
Patiku Iwon	D90 Pass 150um
Chiral Mimọ	≥99.0%
Mimo	≥99.0%
Ayẹwo	98.0% ~ 102.0%
Awọn ohun elo ti o ku	Ni ibamu pẹlu awọn ibeere ICH
Gbigbe	Sowo Pẹlu Ice Pack
Igbeyewo Standard	Standard Enterprise
Lilo	API, ni itọju ti Aarun ayọkẹlẹ A ati Aarun ayọkẹlẹ B

Package & Ibi ipamọ:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

Awọn anfani:

FAQ:

1985606-14-1 - Ohun elo:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) jẹ oogun apakokoro ti o dagbasoke nipasẹ Shionogi Co., ile-iṣẹ elegbogi Japanese ati Roche fun itọju aarun ayọkẹlẹ A ati awọn akoran aarun ayọkẹlẹ B.A fọwọsi oogun naa ni ibẹrẹ fun lilo ni Ilu Japan ni Oṣu Keji ọdun 2018 ati fọwọsi nipasẹ FDA ni Oṣu Kẹwa Ọjọ 24, Ọdun 2018 fun itọju aarun ayọkẹlẹ ti ko ni idiju ni awọn alaisan ti o jẹ ọdun 12 ati agbalagba ti o ti jẹ aami aisan fun ko ju wakati 48 Label lọ.Baloxavir marboxil, a cap-endonuclease inhibitor, ni ọna iṣe adaṣe alailẹgbẹ kan nigbati a bawe si kilasi oogun inhibitor neuraminidase ti o wa lọwọlọwọ ti a lo lati tọju awọn akoran aarun ayọkẹlẹ.Baloxavir Marboxil jẹ oogun apakokoro aarun ayọkẹlẹ tuntun pẹlu ẹrọ iṣe tuntun.Baloxavir Marboxil jẹ prodrug ti Baloxavir Acid (S-033447) ti o ni agbara ati yiyan ṣe idiwọ endonuclease ti o gbẹkẹle fila laarin apakan polymerase PA ti aarun ayọkẹlẹ A ati B, ti o yori si idinamọ ti transcription RNA ati ẹda.Baloxavir tun ti ṣe iwadii fun agbara rẹ lati tọju COVID-19 ṣugbọn ko si anfani ti a fihan ti a ṣe akiyesi.

1985606-14-1 - Ilana ti Ise:

Baloxavir Marboxil jẹ aṣoju itọju aarun ayọkẹlẹ kan, pataki, inhibitor enzymu kan ti o fojusi iṣẹ ṣiṣe endonuclease ti o gbẹkẹle ọlọjẹ aarun ayọkẹlẹ, ọkan ninu awọn iṣe ti eka polymerase ọlọjẹ naa.Ni pataki, o ṣe idiwọ ilana kan ti a mọ si jija fila, nipasẹ eyiti ọlọjẹ naa n gba kukuru, awọn alakoko ti a fi silẹ lati awọn iwe afọwọkọ sẹẹli RNA ti gbalejo, eyiti o lo fun iṣelọpọ polymerase-catalyzed ti awọn mRNA ti o nilo gbogun ti o nilo.Subunit polymerase kan sopọ mọ awọn ami-mRNA ti ogun ni awọn bọtini 5' wọn, lẹhinna iṣẹ ṣiṣe endonuclease polymerase ṣe itusilẹ fifọ rẹ “lẹhin awọn nucleotides 10-13”.Bii iru bẹẹ, ẹrọ rẹ yatọ si awọn inhibitors neuraminidase bii Oseltamivir ati Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil jẹ oludena ti o yan ti aarun ayọkẹlẹ fila-ti o gbẹkẹle endonuclease eyiti o ṣe idiwọ iṣẹ polymerase ati nitorinaa aarun ayọkẹlẹ mRNA ẹda 5, 3. O ti ṣe afihan iṣẹ ṣiṣe itọju ailera lodi si aarun ayọkẹlẹ A ati awọn akoran ọlọjẹ B, pẹlu awọn igara sooro si awọn aṣoju antiviral lọwọlọwọ 1. Oogun yii. ṣe idinamọ enzymu kan ti o nilo fun atunwi gbogun, nitorinaa nyara itọju arun ọlọjẹ 5, Aami ati idinku awọn aami aiṣan ti o ni nkan ṣe pẹlu ikolu.Iwọn kan ti aṣoju yii ni a fihan pe o ga ju ibi-aye lọ ni yiyọkuro awọn aami aisan aarun ayọkẹlẹ ati ti o ga ju mejeeji oseltamivir ati oogun ibibo ni awọn abajade virologic (ti a samisi nipasẹ idinku ẹru gbogun).

1985606-14-1 - Awọn itọkasi:

Baroxavir dara fun awọn alaisan ≥ 12 ọdun atijọ ti o jiya lati aarun ayọkẹlẹ ti ko ni idiju ati ti awọn ami aisan rẹ ko kọja awọn wakati 48.Ifarabalẹ yẹ ki o san si awọn idiwọn ti oogun: ọlọjẹ aarun ayọkẹlẹ yipada ni akoko pupọ, ati pe awọn okunfa bii iru ọlọjẹ ati subtype wa.Ni kete ti ilodisi oogun ti ọlọjẹ ati pathogenicity ti ọlọjẹ naa yipada, ipa ile-iwosan ti awọn oogun antiviral le jẹ alailagbara.Nigbati o ba pinnu boya lati mu basalovir dipivoxil, alaye ti o wa lori ifamọ ti igara ọlọjẹ ajakale-arun agbegbe si oogun yẹ ki o gbero.

1985606-14-1 - Nlo:

Baloxavir Marboxil jẹ oogun aarun ayọkẹlẹ, antiviral, eyiti a mu bi tabulẹti iwọn lilo kan, nipasẹ ẹnu, nipasẹ awọn ẹni-kọọkan ti o jẹ ọdun 12 ti ọjọ-ori tabi agbalagba, ti o ti ṣafihan awọn ami aisan ti ikolu yii fun ko ju wakati 48 lọ. baloxavir marboxil ti a nṣakoso lẹhin awọn wakati 48 ko ti ni idanwo.

1985606-14-1 - Awọn ilodisi:

Baloxavir Marboxil ko yẹ ki o jẹ iṣakoso pẹlu awọn ọja ifunwara, awọn ohun mimu ti o ni agbara kalisiomu, tabi awọn laxatives, antacids, tabi awọn afikun ẹnu ti o ni kalisiomu, irin, iṣuu magnẹsia, selenium, aluminiomu tabi zinc.

1985606-14-1 - Awọn ipa ẹgbẹ:

Awọn ipa ẹgbẹ ti o wọpọ ni atẹle iwọn lilo iwọn lilo kan ti baloxavir marboxil pẹlu gbuuru, anm, otutu ti o wọpọ, orififo, ati ríru.Awọn iṣẹlẹ buburu ni a royin ni 21% ti awọn eniyan ti o gba baloxavir, 25% ti awọn ti ngba placebo, ati 25% ti Oseltamivir.

1985606-14-1 - Igbaradi:

Itọsi Japanese JP6212678 ṣe ijabọ ọna iṣelọpọ ti Baloxavir Marboxil.3, 4-difluorobenzoic acid ni a lo bi ohun elo aise lati fesi pẹlu DMF labẹ iṣẹ LDA lati gba 2-formyl-3, 4-difluorobenzoic acid.Lẹhinna o ṣe thioacetal pẹlu thiophenol, lẹhinna o dinku ati pin pẹlu borane lati gba 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -ọkan, ati nikẹhin bọtini thiazepine ajeku. 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-ọti ni a gba labẹ idinku iṣuu borohydride.Lilo 3- (benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid lati fesi pẹlu tert-butyl formate lẹhin esterification lati gba 3- (benzyloxy) -1- ((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, ati lẹhinna pẹlu 2- (2-, 2-dimethoxyethoxy) ethylamine faragba iyipada urethane paṣipaarọ, ati lẹhinna cyclizes labẹ iṣẹ ti methanesulfonic acid lati gba 7- (benzyloxy) -3, (benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, lẹhinna o jẹ condensed pẹlu (R) -tetrahydrofuran -2-formic acid, lẹhinna crystallized ati ipinnu, ati lẹhinna a ti yọ ẹgbẹ oluranlọwọ chiral kuro lati gba moleku obi obi chiral bọtini (R) -7- (benzyloxy) -3,4,12, 12a-tetrahydro-1H- [1,4] oxazino [3,4-c] pyrido [2,1-f] [1,4] Triazine-6, 8-dione.Lẹhinna a lo molikula oruka obi bọtini lati ṣe paṣipaarọ pẹlu n-hexanol labẹ iṣe ti Grignard reagent, ati lẹhinna pẹlu bọtini thiazepine ajeku 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-ọti-docking ọti. , ati nipari debutylation ati condensation pẹlu methyl chloroformate lati gba ik ọja Baloxavir Marboxil.