Betamethasone CAS 378-44-9 Mimo 97.0% ~ 103.0% API Factory High Purity Ifaworanhan Aworan

Betamethasone CAS 378-44-9 Mimọ 97.0%~103.0% API Factory High Purity

Apejuwe kukuru:

Orukọ Kemikali: Betamethasone

CAS: 378-44-9

Irisi: Funfun tabi Fere White Crystalline Powder

Mimọ: 97.0% ~ 103.0% ti C22H29FO5, lori ipilẹ ti o gbẹ

API Didara Giga, Iṣelọpọ Iṣowo

Olubasọrọ: Dokita Alvin Huang

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E-Mail: alvin@ruifuchem.com

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378-44-9 - Apejuwe:

Ipese Iṣowo Betamethasone pẹlu Mimo Giga ati Didara Idurosinsin
Orukọ Kemikali: Betamethasone
CAS: 378-44-9

378-44-9 -Kemikali Properties:

Orukọ Kemikali	Betamethasone
Awọn itumọ ọrọ sisọ	Ipilẹ Betamethasone;9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dion;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dion
Nọmba CAS	378-44-9
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular	C22H29FO5
Òṣuwọn Molikula	392.47
Ojuami Iyo	235.0 ~ 237.0 ℃
Sowo Ipò	Labẹ Ibaramu otutu
COA & MSDS	Wa
Brand	Ruifu Kemikali

378-44-9 -Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun tabi Fere White Crystalline Powder
Idanimọ A	Gbigba infurarẹẹdi
Idanimọ B	Tinrin-Layer Idanimọ Chromatographic
Specific Optical Yiyi	+ 118.0° si +126.0° (Ṣiṣiro lori ipilẹ ti o gbẹ)
Olukuluku Aimọ	≤1.00%
Lapapọ Awọn Aimọ	≤2.00%
Ajẹkù Solvents kẹmika	≤3000ppm
Awọn ohun elo ti o ku chloroform	≤60ppm
Pipadanu lori Gbigbe	≤0.50% (Gbẹ ni 105 ℃, awọn wakati 3)
Aloku lori Iginisonu	≤0.20%
Mimọ / Analysis Ọna	97.0% ~ 103.0% ti C22H29FO5 Ti ṣe iṣiro lori ipilẹ gbigbe
Igbeyewo Standard	Pharmacopoeia Kannada (CP);EP10.0 ati USP 42
Iṣakojọpọ ati Ibi ipamọ	Fipamọ ninu awọn apoti ti o nipọn.Tọju laarin 2 ℃ ati 30 ℃.
Ohun elo	Ohun elo elegbogi ti nṣiṣe lọwọ (API)

Package & Ibi ipamọ:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apoti naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 30 ℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Duro kuro lati ina to lagbara ati ooru, ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

Awọn anfani:

FAQ:

378-44-9 - Ewu ati Aabo:

Awọn koodu Ewu R40 - Ẹri to lopin ti ipa carcinogenic kan
R48/20/21 -
R61 - Le fa ipalara si awọn unborn ọmọ
Apejuwe Aabo S22 - Maṣe simi eruku.
S36 - Wọ aṣọ aabo to dara.
S45 - Ni ọran ti ijamba tabi ti o ba ni ailara, wa imọran iṣoogun lẹsẹkẹsẹ (fi aami han nigbakugba ti o ṣee ṣe.)
S53 - Yago fun ifihan - gba awọn ilana pataki ṣaaju lilo.
WGK Germany 2
RTECS TU4000000
HS koodu 2937229000
Majele ti LD50 ẹnu ni Asin:> 4500mg/kg

378-44-9 -Ohun elo:

Betamethasone (CAS: 378-44-9), jẹ ti awọn corticosteroids adrenal, o jẹ isomer ti dexamethasone , ati ipa ti betamethasone jẹ iru si prednisolone ati dexamethasone , o ni egboogi-iredodo, egboogi-rheumatic, egboogi-allergic ati titẹkuro. ti ajẹsara ati awọn ipa elegbogi miiran, ipa ipakokoro-egbogi rẹ lagbara ju dexamethasone, triamcinolone, hydrocortisone ati bẹbẹ lọ, o le dinku ati dena idahun tissu si iredodo ati imukuro ooru, pupa ati wiwu ti o ṣẹlẹ nipasẹ iredodo ti ko ni arun agbegbe, nitorinaa dinku iṣẹ iredodo, ipa egboogi-iredodo ti ọja yii 0.3mg jẹ dogba si dexamethasone 0.75mg, prednisone 5mg tabi 25mg cortisone.Ipa idaduro iṣuu soda Betamethasone jẹ igba ọgọrun diẹ sii ju hydrocortisone, ni hypofunction adrenal akọkọ, o le ṣee lo pẹlu glucocorticoid fun aropo itọju ailera, ati pe o lo fun idilọwọ tabi idilọwọ idahun ajẹsara ti sẹẹli, idaduro awọn aati aleji ati idinku ajesara akọkọ. Imugboroosi idahun, o ti lo fun renin kekere ati aarun aldosterone kekere ati aiṣan-ẹjẹ ti ara ẹni ti o fa idamu orthostatic hypotension.Lọwọlọwọ betamethasone tun ti wa ni lilo fun awọn itọju ti nṣiṣe lọwọ rheumatoid Àgì, rheumatoid Àgì, lupus, àìdá ikọ-fèé, àìdá dermatitis, ńlá lukimia, atopic dermatitis, àléfọ, neurodermatitis, seborrheic dermatitis, ati pruritus ati okeerẹ itọju ti awọn àkóràn.Ọja naa jẹ contraindicated ni itan-akọọlẹ ọpọlọ ti o lagbara, ọgbẹ duodenal ti nṣiṣe lọwọ, anastomosis nipa ikun ati inu aipẹ, osteoporosis ti o wuwo, àtọgbẹ, haipatensonu nla, ọlọjẹ, kokoro arun, awọn akoran olu eyiti o kuna lati ṣakoso nipasẹ lilo awọn aṣoju antimicrobial, thrombophlebitis, awọn akoran awọ ara, bii bi impetigo, tinea, jock itch ati be be lo.

378-44-9 - USP35 Standard:

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16) -.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone ko kere ju 97.0 ogorun ati pe ko ju 103.0 ogorun ti C22H29FO5, ṣe iṣiro lori ipilẹ ti o gbẹ.
Iṣakojọpọ ati ibi ipamọ-Fipamọ sinu awọn apoti ti o muna.Tọju laarin 2 ℃ ati 30 ℃.
Awọn ajohunše Itọkasi USP <11>-
USP Betamethasone RS
Idanimọ-
A: Gbigba infurarẹẹdi <197M>.
B: Tinrin-Layer Idanimọ idanimọ Chromatographic <201>-
Idanwo ojutu-Mura ojutu ti Betamethasone ninu ọti ti a gbẹ ti o ni 0.5 mg fun milimita kan.
Idagbasoke eto epo: adalu chloroform ati diethylamine (2: 1).
Ilana-Tẹsiwaju bi a ti ṣe itọsọna ni ori-iwe, ayafi lati wa awọn aaye naa nipa fifẹ die-die pẹlu dilute sulfuric acid (1 ni 2) ati alapapo lori awo gbigbona tabi labẹ fitila titi awọn aaye yoo han.
Yiyi pato <781S>: laarin +118 ati +126, iṣiro lori ipilẹ ti o gbẹ.
Ojutu idanwo: 5 miligiramu fun milimita, ni methanol.
Isonu lori gbigbe 731-Gbẹ ni 105 fun wakati 3: o padanu ko ju 1.0% ti iwuwo rẹ lọ.
Aloku lori iginisonu 281: ko ju 0.2% lọ, a nlo crucible Pilatnomu.
Awọn idoti deede 466-
Ojutu idanwo: kẹmika.
Standard ojutu: kẹmika.
Iwọn ohun elo: 10 µL.
Eluant: adalu toluene, acetone, methyl ethyl ketone, ati formic acid (55:20:20:5), ninu iyẹwu ti ko ni idiwọn.
Ìwòran: 5.
Ayẹwo-
Mobile alakoso-Mura a filtered ati degassed adalu omi ati acetonitrile (63:37).Ṣe awọn atunṣe ti o ba jẹ dandan (wo Ibaramu Eto labẹ Chromatography 621).
Ojutu boṣewa inu-Mura ojutu kan ti propylparaben ninu oti nini ifọkansi ti a mọ ti nipa 0.25 miligiramu fun milimita kan.
Igbaradi boṣewa-Tu opoiye iwọn deede ti USP Betamethasone RS ninu ọti lati gba ojutu kan ti o ni ifọkansi ti a mọ ti bii 0.2 mg fun miligiramu.Gbigbe 10.0 milimita ti ojutu yii si vial ti o dara, ati ṣafikun 10.0 milimita ti ojutu boṣewa Inu, lati gba igbaradi Standard kan ti o mọ awọn ifọkansi ti 0.1 miligiramu ti betamethasone ati nipa 0.125 miligiramu ti propylparaben fun milimita.
Assay igbaradi-Lilo nipa 80 miligiramu ti Betamethasone, wọn deede, mura bi a ti dari fun Standard igbaradi.
Eto Chromatographic (wo Chromatography 621)-Kromatograph olomi ti ni ipese pẹlu aṣawari 240-nm ati iwe 4.6-mm × 25-cm ti o ni iṣakojọpọ L1.Iwọn sisan jẹ nipa 1.0 milimita fun iṣẹju kan.Chromatograph awọn Standard igbaradi, ati ki o gbasilẹ awọn idahun tente bi a ti ṣe itọsọna fun Ilana: awọn akoko idaduro ojulumo jẹ nipa 1.0 fun betamethasone ati 1.4 fun propylparaben;ipinnu, R, laarin betamethasone ati propylparaben ko kere ju 3.0;ati iyapa boṣewa ojulumo fun awọn abẹrẹ ẹda ko ju 2.0%.
Ilana-Lọtọ ara awọn iwọn didun dogba (bii 10 µL) ti igbaradi Standard ati igbaradi Assay sinu chromatograph, ṣe igbasilẹ awọn chromatogram, ati wiwọn awọn idahun fun awọn oke pataki.Ṣe iṣiro iye, ni mg, ti C22H29FO5 ni apakan ti Betamethasone ti o mu nipasẹ agbekalẹ:
800C(RU/RS)
ninu eyiti C jẹ ifọkansi, ni mg fun milimita, ti USP Betamethasone RS ni igbaradi Standard;ati RU ati RS jẹ awọn ipin giga giga ti tente oke betamethasone ati peak boṣewa inu ti a gba lati igbaradi Assay ati igbaradi Standard, lẹsẹsẹ.