Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid CAS 486460-00-8 Purity ≥99.5% (HPLC) Sitagliptin Phosphate Monohydrate Intermediate
Ipese Sitagliptin Phosphate Monohydrate Awọn agbedemeji ibatan:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Agbedemeji CAS 486460-21-3
Orukọ Kemikali | Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid |
Awọn itumọ ọrọ sisọ | (R) - Sitagliptin N-Boc-Acid Aimọ |
Nọmba CAS | 486460-00-8 |
NỌMBA CAT | RF-PI1192 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Ilana molikula | C15H18F3NO4 |
Òṣuwọn Molikula | 333.31 |
Ojuami Iyo | 136.0 ~ 138.0 ℃ |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun to Pa-White Powder |
Idanimọ nipa HPLC | Akoko Idaduro ti Ayẹwo jẹ Concordant Pẹlu Iwọn Itọkasi |
Pipadanu lori Gbigbe | ≤0.50% |
Sulfated Ash | ≤0.50% |
Awọn Irin Eru | <20ppm |
Isomer | ≤0.50% |
Awọn nkan ti o jọmọ | |
Aimọ́ A | ≤0.50% |
Eyikeyi miiran Single aimọ | ≤0.50% |
Lapapọ Awọn Aimọ | ≤0.50% |
Mimo | ≥99.5% (HPLC) |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.
Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid (CAS: 486460-00-8) jẹ agbedemeji pataki fun igbaradi ti sitagliptin.Sitagliptinphosphate ni akọkọ dipeptidase -IV(DPP-4) inhibitor ti a fọwọsi nipasẹ FDA ni ọdun 2006. O jẹ lilo fun itọju iru II diabetes mellitus.O ni ipa hypoglycemic ti o han gbangba nigba lilo nikan tabi ni apapo pẹlu metformin ati pioglitazone, ati pe o jẹ ailewu lati mu, farada daradara, pẹlu awọn aati ikolu diẹ.Ni Oṣu Kẹjọ ọdun 2009, oogun naa ti fọwọsi nipasẹ European Union bi oogun laini akọkọ fun itọju iru àtọgbẹ 2.Lẹhin ọdun 2011, ọkan lẹhin awọn orilẹ-ede miiran ti fọwọsi apapo ti sitagliptin fosifeti ati awọn inhibitors alpha glycosidase tabi hisulini.Sitagliptin fosifeti ni akọkọ FDA-fọwọsi dipeptidyl peptidase-IV inhibitor lati ṣee lo ninu itọju iru àtọgbẹ 2 ni ọna jijin, labẹ orukọ iṣowo Januvia.