Brexpiprazole CAS 913611-97-9 Mimọ>99.0% (HPLC) Ile-iṣẹ API
Ruifu Kemikali Ipese Brexpiprazole Intermediates
Brexpiprazole CAS 913611-97-9
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Orukọ Kemikali | Brexpiprazole |
Awọn itumọ ọrọ sisọ | OPC-34712;7- (4- (4- (Benzo [b] thiophen-4-yl) piperazin-1-yl)butoxy) quinolin-2 (1H) -ọkan |
Nọmba CAS | 913611-97-9 |
NỌMBA CAT | RF-PI1982 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C25H27N3O2S |
Òṣuwọn Molikula | 433.57 |
iwuwo | 1,245 ± 0,060 g / cm3 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Pa-White Crystalline Powder |
Idanimọ | Nipasẹ IR |
RT | Labẹ chirality yẹ ki o ni ibamu |
Kloride | O funni ni esi ti kiloraidi |
Omi | 3.0% ~ 4.5% |
Ojuami Iyo | 198.0 ~ 202.0 ℃ |
Aloku lori Iginisonu | <0.20% |
Awọn irin Heavy | ≤10ppm |
Awọn nkan ti o jọmọ | |
Olukuluku Aimọ | <0.50% |
Lapapọ Awọn Aimọ | <1.00% |
EE | > 99.0% |
Mimọ / Analysis Ọna | > 99.0% (HPLC, lori ipilẹ gbigbẹ) |
Igbeyewo Standard | Standard Enterprise |
Lilo | API |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Brexpiprazole (CAS: 913611-97-9) jẹ oludije oogun ti o wulo ni itọju ati idena awọn rudurudu ọpọlọ pẹlu awọn rudurudu CNS.Brexpiprazole jẹ oogun apakokoro aramada aramada eyiti o ṣe iranṣẹ bi serotonin ® oluyipada iṣẹ ṣiṣe dopamine ati pe o ti ṣe afihan imunadoko bi itọju ajumọṣe ni awọn alaisan ti o ni rudurudu irẹwẹsi nla (MDD).Brexpiprazole ṣe afihan profaili elegbogi alailẹgbẹ kan, ti n ṣiṣẹ bi agonist apa kan ti serotonin 5-HT1A ati awọn olugba dopamine D2 ati bi antagonist kikun ti 5-HT2A ati awọn olugba noradrenaline α1B/2C, pẹlu iru isunmọ isọdọkan subnanomolar.Brexpiprazole jẹ idagbasoke nipasẹ Otsuka ati Lundbeck, ti a fọwọsi ni ọdun 2015 nipasẹ FDA fun itọju schizophrenia ati bi itọju ajunsi fun ibanujẹ.Brexpiprazole ni a gba pe o jẹ arọpo si oogun antipsychotic Otsuka aripiprazole (orukọ iṣowo Abilify) eyiti itọsi rẹ pari ni Oṣu Kẹjọ ọdun 2014.