Candesartan CAS 139481-59-7 Mimọ> 99.0% (HPLC) Ile-iṣẹ
Ipese Kemikali Ruifu Candesartan Cilexetil Intermediate Pẹlu Iwa-mimọ giga
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Triyl Candesartan Cilexetil CAS 170791-09-0
Orukọ Kemikali | Candesartan |
Awọn itumọ ọrọ sisọ | CV-11974;2-Ethoxy-1-[[2'- (1H-tetrazol-5-yl) [1,1'-biphenyl] -4-yl]methyl] -1H-Benzimidazole-7-Carboxylic Acid;3-[[2'- (1H-Tetrazol-5-yl) biphenyl-4-yl]methyl] -2-ethoxy-3H-Benzimidazole-4-Carboxylic Acid;Candesartan M1;Candesartan Cilexetil EP Impurity G |
Nọmba CAS | 139481-59-7 |
NỌMBA CAT | RF-PI1889 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Ilana molikula | C24H20N6O3 |
Òṣuwọn Molikula | 440.45 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun Powder |
Idanimọ-HPLC | Akoko Idaduro Iru si Standard |
Idanimọ-IR | Iru si Standard |
Mimọ / Analysis Ọna | > 99.0% (HPLC) |
Ojuami Iyo | 183.0 ~ 185.0 ℃ |
Pipadanu lori Gbigbe | <0.50% |
Ọrinrin (KF) | <0.50% |
Aloku lori Iginisonu | <0.50% |
Awọn irin Heavy | <20ppm |
Olukuluku Aimọ | <1.00% (HPLC) |
Lapapọ Awọn Aimọ | <1.00% (HPLC) |
Atọka Refractive | n20 / D 1.745 ~ 1.747 |
Igbeyewo Standard | Standard Enterprise |
Lilo | API;Fun itọju Haipatensonu |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Candesartan (CAS: 139481-59-7) jẹ angiotensin II antagonist olugba pẹlu IC50 ti 0.26 nM.Ifojusi: Angiotensin II Olugba candesartan jẹ itọkasi fun itọju haipatensonu.Candesartan Cilexetil ni a fọwọsi ni akọkọ ni GB ni Oṣu Kẹrin Ọjọ 29, Ọdun 1997, lẹhinna fọwọsi nipasẹ Ile-iṣẹ Ounje ati Oògùn AMẸRIKA (FDA) ni Oṣu Karun ọjọ 4, ọdun 1998, ati fọwọsi nipasẹ Awọn elegbogi ati Ile-iṣẹ Awọn Ẹrọ Iṣoogun ti Japan (PMDA) ni Oṣu Kẹta Ọjọ 12, Ọdun 1999. O jẹ idagbasoke nipasẹ AstraZeneca, lẹhinna ṣe tita bi Atacand nipasẹ AstraZeneca ni GB ati AMẸRIKA, ati tita bi Blopress nipasẹ Takeda ni JP.Candesartan Cilexetil jẹ blocker olugba angiotensin II (ARB), o ṣe idiwọ vasoconstrictor ati awọn ipa ikọkọ aldosterone ti angiotensin II nipa yiyan dina asopọ ti angiotensin II si olugba AT1 ni ọpọlọpọ awọn ara, gẹgẹ bi isan dan ti iṣan ati ẹṣẹ adrenal.Atacand jẹ itọkasi fun itọju ti haipatensonu ninu awọn agbalagba ati awọn ọmọde 1 si <17 ọdun ti ọjọ ori, ikuna ọkan (NYHA kilasi II-IV) ati pe a lo lati dinku iku ẹjẹ ọkan ati ile iwosan ikuna ọkan.