Carvedilol CAS 72956-09-03 Mimo> 99.0% (HPLC) Aworan ti a ṣe afihan

Carvedilol CAS 72956-09-03 Mimọ>99.0% (HPLC)

Apejuwe kukuru:

Orukọ Kemikali: Carvedilol

CAS: 72956-09-03

Mimọ:> 99.0% (HPLC)

Irisi: White Crystalline Powder

Olubasọrọ: Dokita Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Apejuwe:

Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Carvedilol (CAS: 72956-09-03) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Carvedilol,Please contact: alvin@ruifuchem.com

Jẹmọ Intermediates:

Jẹmọ Intermediates ti Carvedilol

N- (2- (2-Methoxyphenoxy) ethyl) benzylamine Hydrochloride	CAS: 3246-03-5
2- (2-Methoxyphenoxy) ethylamine Hydrochloride Hydrate	CAS 64464-07-9
2- (2-Methoxyphenoxy) ethylamine	CAS 1836-62-0
4- (2,3-Epoxypropoxy) carbazole	CAS 51997-51-4
4-Hydroxycarbazole	CAS 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9
Carvedilol	CAS 72956-09-03
Carvedilol Phosphate Hemihydrate	CAS 610309-89-2

Kemikali Properties:

Orukọ Kemikali	Carvedilol
Awọn itumọ ọrọ sisọ	1- (9H-Carbazol-4-yloxy) -3- [[2- (2-Methoxyphenoxy) ethyl] amino] -2-Propanol;Olorin;Cadilan;Carca;Cardivas;Carloc;Carfasi;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardiiki;Korvasan;Kredex;Querto;Talliton;BM-14190
Iṣura Ipo	Ninu Iṣura, Iṣowo GMP
Nọmba CAS	72956-09-3
Fọọmu Molecular	C24H26N2O4
Òṣuwọn Molikula	406,48 g / mol
Ojuami Iyo	115.0 si 119.0 ℃
iwuwo	1,250 ± 0,06 g / cm3
Solubility ninu Omi	Ailopin ninu Omi
Solubility	Tiotuka ni kẹmika.Tiotuka diẹ ni Ethanol, Eteri
Ibi ipamọ otutu.	Itura & Ibi Gbẹ (2 ~ 8℃)
COA & MSDS	Wa
Brand	Ruifu Kemikali

Awọn pato:

Awọn nkan	Ayewo Standards	Esi
Ifarahan	Funfun Crystalline Powder	Ibamu
Pipadanu lori Gbigbe	≤0.50% (105℃ fun wakati 3)	0.25%
Aloku lori Iginisonu	≤0.10%	0.07%
Awọn nkan ti o jọmọ
Lapapọ Awọn Aimọ	≤0.50%	Ibamu
Aimọ́ A	≤0.20%	Ibamu
Iwa aimọ C	≤0.02%	Ibamu
Eyikeyi miiran Olukuluku aimọ	≤0.10%	Ibamu
Awọn Irin Eru (Pb)	≤10ppm	<10ppm
Mimọ / Analysis Ọna	> 99.0% (HPLC)	99.72%
Infurarẹẹdi julọ.Oniranran	Ni ibamu si Eto	Ibamu
Ipari	Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato

Package/Ipamọ/Gbigbe:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Tọju ni wiwọ titi eiyan.Fipamọ sinu itura, gbigbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

Awọn anfani:

Agbara to to: Awọn ohun elo to ati awọn onimọ-ẹrọ

Iṣẹ Ọjọgbọn: Iṣẹ rira iduro kan

OEM Package: Aṣa package ati aami wa

Ifijiṣẹ Yara: Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta

Ipese Idurosinsin: Ṣetọju ọja iṣura ti o tọ

Atilẹyin imọ-ẹrọ: Ojutu imọ-ẹrọ wa

Iṣẹ Iṣọkan Aṣa: Larin lati giramu si kilos

Didara to gaju: Ṣeto eto idaniloju didara pipe

FAQ:

Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.

Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.

Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.

DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl

Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.

Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.

MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.

Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.

Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.

Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.

Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.

Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.

72956-09-3 - Alaye Abo:

Awọn koodu ewu N, Xn
Awọn alaye Ewu 51/53-36/37/38-20/21/22
Awọn alaye Aabo 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardClass IRRTANT
IṣakojọpọGroup III
Data Awọn nkan elewu 72956-09-3(Data Awọn nkan elewu)
Majele ti LD50 ẹnu ni aja:> 1gm/kg

72956-09-3 -Ohun elo:

Carvedilol (CAS: 72956-09-03) jẹ vasodilating beta-blocker ti o wulo ni itọju haipatensonu ati angina pectoris.Ni afikun si idinku titẹ ẹjẹ silẹ, carvedilol dinku lapapọ resistance iṣọn-ẹjẹ laisi tachycardia reflex nigbagbogbo n waye pẹlu awọn vasodilators.O ti royin pe o farada daradara pẹlu awọn ipa ifoju kidirin.

Carvedilol ni akọkọ ṣe ifilọlẹ ni Bẹljiọmu ni ọdun 1985. Ọja yii le dina alpha ati awọn olugba beta, ko si iṣẹ inu, ni awọn ifọkansi giga ti aṣa pẹlu antagonism kalisiomu.O ni ipa to lagbara ti didi awọn olugba beta, eyiti o le faagun awọn ohun elo ẹjẹ, dinku resistance agbeegbe ati titẹ ẹjẹ kekere, ati pe o ni ipa diẹ lori iṣelọpọ ọkan ati oṣuwọn ọkan.Ile-iwosan le ṣee lo fun haipatensonu akọkọ ati angina pectoris.

72956-09-3 - USP 35 Standard:

ITUMO

Carvedilol ni NLT 98.0% ati NMT 102.0% ti C24H26N2O4, iṣiro lori ipilẹ ti o gbẹ.

Ìdámọ̀

• A. Gbigba infurarẹẹdi <197K>

• B. Awọn akoko idaduro ti awọn pataki tente oke ti awọn Ayẹwo ojutu ni ibamu si awọn ti Standard ojutu, bi gba ninu awọn Assay.

ASAY

• Ilana

Idaduro: 2.72 g/L ti fosifeti potasiomu monobasic.Ṣatunṣe pẹlu dilute phosphoric acid si pH ti 2.0.

Abala alagbeka: Acetonitrile ati Buffer (31:69)

Ojutu ibaamu eto: 0.05 mg/mL kọọkan ti USP Carvedilol RS ati USP Carvedilol Compound ti o jọmọ A RS ni apakan Alagbeka

Ojutu boṣewa: 0.04 mg/mL ti USP Carvedilol RS ni alakoso Alagbeka

Ojutu ayẹwo: 0.04 mg / mL ti Carvedilol ni alakoso Alagbeka

Eto Chromatographic

(Wo Chromatography <621>, Ibamu Eto.)

Ipo: LC

Oluwadi: UV 240 nm

Ọwọn: 4.6-mm × 15-cm;5-µm iṣakojọpọ L7

Iwọn otutu: 55 ℃

Oṣuwọn sisan: 1 milimita / min

Akoko ṣiṣe: 60 min

Iwọn abẹrẹ: 10 µL

Ibamu eto

Apeere: Eto ibamu ojutu

Awọn ibeere ibamu

Ipinnu: NLT 4.0 laarin carvedilol ati carvedilol ti o ni ibatan agbo A

Idiwọn tailing: NMT 1.5 fun oke carvedilol

Iyatọ boṣewa ibatan: NMT 2%

Onínọmbà

Awọn apẹẹrẹ: Ojutu boṣewa ati ojutu Ayẹwo

Ṣe iṣiro ipin ti carvedilol (C24H26N2O4) ni apakan ti ayẹwo ti o mu:

Esi = (rU/rS) × (CS/CU) × 100

rU=	tente esi ti carvedilol lati Ayẹwo ojutu
rS=	tente esi ti carvedilol lati Standard ojutu
CS=	ifọkansi ti carvedilol ninu ojutu Standard (mg/mL)
CU=	ifọkansi ti Carvedilol ni ojutu Ayẹwo (mg/mL)

Awọn ilana gbigba: 98.0% -102.0% lori ipilẹ ti o gbẹ

ALÁÌṢẸ́

• Aloku lori Iginisonu <281>: NMT 0.1% lati 1 g

• Awọn irin Heavy, Ọna II <231>: NMT 10 ppm

• Organic impurities, Ilana 1: [Akiyesi-Lori awọn ipilẹ ti awọn impurities bayi, ṣe boya Organic impurities, Ilana 1 tabi Organic impurities, Ilana 2. Organic impurities, Ilana 2 ti wa ni niyanju nigbati carvedilol jẹmọ yellow F jẹ kan ti o pọju aimọ.]

Buffer ati Alagbeka alakoso: Mura bi a ti ṣe itọsọna ni Assay.

Ojutu ibaamu eto: 0.05 mg/mL kọọkan ti USP Carvedilol RS ati USP Carvedilol Jẹmọ Compound C RS ni apakan Alagbeka

Ojutu boṣewa: 1 µg/mL kọọkan ti USP Carvedilol RS, USP Carvedilol ibatan Compound A RS, USP Carvedilol ibatan Compound B RS, USP Carvedilol Jẹmọ Compound D RS, ati USP Carvedilol Jẹmọ Compound E RS, ati 0.2 µg/mL ti USP Carvedil Jẹmọ yellow C RS ni Mobile alakoso

Ojutu ayẹwo: 1 mg / mL ti Carvedilol ni alakoso Alagbeka

Eto Chromatographic

(Wo Chromatography <621>, Ibamu Eto.)

Ipo: LC

Oluwadi: Meji wefulenti, UV 220 ati 240 nm.Lo 220 nm fun pipo carvedilol ti o ni ibatan yellow E, ati lo 240 nm fun carvedilol ati gbogbo awọn agbo ogun ti o jọmọ.

Ọwọn: 4.6-mm × 15-cm;5-µm iṣakojọpọ L7

Iwọn otutu: 55 ℃

Oṣuwọn sisan: 1 milimita / min

Iwọn abẹrẹ: 20µL

Ibamu eto

Apeere: Eto ibamu ojutu

Awọn ibeere ibamu

Ipinnu: NLT 17 laarin carvedilol ati carvedilol ti o ni ibatan agbo C

Onínọmbà

Awọn apẹẹrẹ: Ojutu boṣewa ati ojutu Ayẹwo

Ṣe iṣiro ipin ogorun ti carvedilol ti o ni ibatan A, carvedilol ti o ni ibatan B, carvedilol ti o ni ibatan C, carvedilol ti o jọmọ yellow D, carvedilol ti o ni ibatan yellow E, ati eyikeyi aimọ kọọkan miiran ni ipin ti Carvedilol ti o mu:

Esi = (rU/rS) × (CS/CU) × 100

rU	=	esi ti o ga julọ ti agbo ti o ni ibatan ti o baamu tabi eyikeyi aimọ miiran lati inu ojutu Ayẹwo
rS	=	tente esi ti awọn ti o baamu jẹmọ yellow lati Standard ojutu.Lati ṣe iṣiro ipin ogorun ti eyikeyi aimọ kọọkan miiran lo idahun ti o ga julọ ti carvedilol.
CS	=	ifọkansi ti idapọ ti o ni ibatan ti o baamu ni ojutu Standard (mg/mL).Lati ṣe iṣiro ipin ogorun eyikeyi awọn idoti miiran fun CS, lo ifọkansi ti USP Carvedilol RS.
CU	=	ifọkansi ti Carvedilol ni ojutu Ayẹwo (mg/mL)

Ilana gbigba: Wo Tabili 1.

Tabili 1

Oruko	Ojulumo Idaduro Time	Awọn Ilana Gbigba, NMT (%)
Carvedilol ti o ni ibatan pẹlu Ea	0.35	0.1
Carvedilol ti o ni ibatan si Ab	0.52	0.1
Carvedilol bisalkylpyrocatechol itọsẹ (ti o ba wa)c	0.70	0.15
Carvedilol	1.0	-
Carvedilol ti o ni ibatan Cd	3.6	0.02
Carvedilol ti o ni ibatan De	5.0	0.1
Carvedilol ti o ni ibatan pẹlu Bf	8.5	0.1
Eyikeyi miiran ti olukuluku aimọ	-	0.10
Lapapọ awọn idoti	-	0.5g
2- (2-Methoxyphenoxy) ethyl amine. b 1- (4- (2-Hydroxy-3---2--methoxyphenoxy) ethylamino) aṣoju-9H-carbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol. e 4- (Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3 ¢ (2- (2-Methoxyphenoxy) ethylazanediyl) bis (1- (9H-carbazol-4-yloxy) propan-2-ol). g Fojusi eyikeyi aimọ ti o kere ju 0.01%.

• Awọn Egbin Organic, Ilana 2

Solusan A: Acetonitrile ati trifluoroacetic acid (100: 0.1)

Solusan B: Trifluoroacetic acid ati omi (0.1: 100)

Diluent: Acetonitrile, trifluoroacetic acid, ati omi (22:0.1:78)

Ipele Alagbeka: Wo Tabili 2

Tabili 2

Aago (iṣẹju)	Ojutu A (%)	Ojutu B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Ojutu ìbójúmu eto: 1.0 mg/mL ti USP Carvedilol System Imudara Adalu RS ni Diluent

Ojutu ayẹwo: 1 mg / mL ti Carvedilol ni Diluent

Eto Chromatographic

(Wo Chromatography <621>, Ibamu Eto.)

Ipo: LC

Oluwadi: UV 240 nm

Ọwọn: 4.6-mm x 15-cm;5-µm iṣakojọpọ L68

Iwọn otutu: 30 ℃

Oṣuwọn sisan: 1.4 milimita / min

Iwọn abẹrẹ: 20µL

Ibamu eto

Apeere: Eto ibamu ojutu

Awọn ibeere ibamu

Ipinnu: NLT 1.8 laarin carvedilol ati carvedilol ti o ni ibatan agbo F

Onínọmbà

Apeere: Apeere ojutu

Ṣe iṣiro ipin ogorun aimọ kọọkan ni apakan ti Carvedilol ti o mu:

Abajade = (rU/rT) × 100

rU	=	idahun ti o ga julọ fun aimọ kọọkan ninu ojutu Ayẹwo
rT	=	apao gbogbo awọn idahun ti o ga julọ ni ojutu Ayẹwo

Ilana gbigba: Wo Tabili 3.

Tabili 3

Oruko	Ojulumo Idaduro Aago	Gbigba Awọn ilana, NMT (%)
Carvedilol ti o ni ibatan si Aa	0.7	0.1
Carvedilol	1.0	-
Carvedilol idapọmọra Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Carvedilol ti o ni ibatan Ce	1.8	0.02
Carvedilol ti o ni ibatan pẹlu Bf	2.1	0.1
Biscarbazoleg	3	0.1
Eyikeyi miiran ti olukuluku aimọ	-	0.1
Lapapọ awọn idoti	-	0.5
a 1- (4- (2-Hydroxy-3-- (2--methoxyphenoxy) ethylamino) propoxy) -9Hcarbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2-ol . b 1- (2- (2-Methoxyphenoxy) ethylamino) -3- (6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol. c Iwa aimọ yii jẹ iwọn ni lilo ilana labẹ Awọn aiṣedeede Organic, Ilana 3: Compound ibatan Carvedilol F. d 1- (H-Carbazol-4-yloxy) -3-[[2- (2-methoxyphenoxy) ethyl] N-isopropylamino] -2-propanol. e 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol. f 3,3'- (2- (2-Methoxyphenoxy) ethylazanediyl) bis (1- (9H-carbazol-4-yloxy) propan-2-ol). g 1,3-Bis- (9H-carbazol-4-yloxy) -2-propanol.

• Awọn aimọ Organic, Ilana 3: Agbo ibatan Carvedilol F (ti o ba wa)

Solusan A: Trifluoroacetic acid ati omi (0.5: 100)

Solusan B: Methanol ati trifluoroacetic acid (100: 0.5)

Diluent: Omi ati acetonitrile (1:1)

Ipele Alagbeka: Solusan A ati Solusan B (65:35)

Ojutu ìbójúmu eto: 1.5 mg/mL ti USP Carvedilol System Imudara Adalu RS ni Diluent

Ojutu ayẹwo: 1.5 mg / mL ti Carvedilol ni Diluent ti pese sile gẹgẹbi atẹle.Lo nipa 1.9 milimita ti Diluent fun miligiramu ti Carvedilol, ati sonicate ni ṣoki lati dẹrọ itu.

Eto Chromatographic

(Wo Chromatography <621>, Ibamu Eto.)

Ipo: LC

Oluwadi: UV 226 nm

Ọwọn: 4.6-mm × 30-mm;3-µm iṣakojọpọ L7

Iwọn otutu: 40 ℃

Oṣuwọn sisan: 2 milimita / min

Iwọn abẹrẹ: 10 µL

Ibamu eto

Apeere: Eto ibamu ojutu

Awọn ibeere ibamu

Ipinnu: NLT 2.0 laarin carvedilol ati carvedilol ti o ni ibatan agbo F

Onínọmbà

Apeere: Apeere ojutu

Ṣe iṣiro ipin ti carvedilol ti o ni ibatan agbo F ni apakan ti ayẹwo ti o mu:

Abajade = (rU/rT) × (1/F) × 100

rU	=	esi ti o ga julọ ti carvedilol ti o ni ibatan agbo F lati inu ojutu Ayẹwo
rT	=	apao awọn idahun ti o ga julọ ti carvedilol ati carvedilol ti o ni ibatan agbo F lati inu ojutu Ayẹwo
F	=	ojulumo esi ifosiwewe, 1.1

Ilana gbigba: NMT 0.1%

Awọn idanwo pataki

• Isonu lori Gbigbe <731>: Gbẹ ayẹwo ni 105 ℃ fun 3 h: o padanu NMT 0.5% ti iwuwo rẹ.

Awọn ibeere afikun

• Iṣakojọpọ ati Ibi ipamọ: Fipamọ sinu awọn apoti ti o nipọn, ati tọju ni iwọn otutu yara iṣakoso.

• Ifi aami: Ti o ba ti lo idanwo fun Organic impurities nipasẹ HPLC yatọ si Ilana 1, lẹhinna aami naa sọ idanwo pẹlu eyiti nkan naa ṣe.

• Awọn Ilana Itọkasi USP <11>

USP Carvedilol RS

USP Carvedilol Jẹmọ yellow A RS
1- (4- (2-Hydroxy-3- (2---methoxyphenoxy) ethylamino) propoxy) -9H-carbazol-9-yl) -3- (2- (2-methoxyphenoxy) ethylamino) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Jẹmọ Agbo B RS
3,3'- (2- (2-Methoxyphenoxy) ethylazanediyl) bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Jẹmọ Agbo C RS
1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl) amino) propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Jẹmọ Agbo D RS
4- (Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Jẹmọ Agbo E RS
2- (2-Methoxyphenoxy) ethyl amin.
C9H13NO2 167.21

USP Carvedilol System Ibamu Adalu RS
Adalu ti isunmọ 0.1% carvedilol ti o ni ibatan agbo F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) ni a matrix ti carvedilol oògùn nkan na.