Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Mimọ>98.0% (HPLC)
Shanghai Ruifu Kemikali Co., Ltd jẹ oludari ti Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, kekere ati awọn iwọn olopobobo ti o wa.Ra Daclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Di-tert-Butyl (2S,2'S) -2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di (1-Pyrrolidinecarboxylate) |
| Awọn itumọ ọrọ sisọ | Daclatasvir Intermediate Ⅱ;Dacaltasvir Intermediate 02;Daclatasvir T-Butyl Ester;Bis (2-Methyl-2-Propanyl) (2S,2'S) -2,2'- [4,4'-Biphenyldiylbis (1H-Imidazole-4,2-diyl)] di (1-Pyrrolidinecarboxylate);Di-tert-butyl 2,2′-([1,1'-Biphenyl] -4,4'-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- Carboxylate);(2S,2'S)-2,2'-([1,1'-Biphenyl] -4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Daclatasvir aimọ 4 |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 1007882-23-6 |
| Fọọmu Molecular | C40H51ClN8O6 |
| Òṣuwọn Molikula | 775,35 g / mol |
| Ojuami farabale | 890.2± 65.0℃ ni 760 mmHg |
| iwuwo | 1.220 ± 0,06 g / cm3 |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | Agbedemeji ti Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Brand | Ruifu Kemikali |
| Awọn nkan | Awọn pato | Esi |
| Ifarahan | Ina Yellow to Yellow Powder | Imọlẹ Yellow Powder |
| Pipadanu lori Gbigbe | <1.00% | 0.65% |
| O pọju Nikan Aimọ | <1.00% | 0.45% |
| Lapapọ Awọn Aimọ | <2.00% | 1.24% |
| Mimọ / Analysis Ọna | > 98.0% (HPLC) | 98.76% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| 1H NMR julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
| Ohun elo | Agbedemeji ti Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Apo:Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati fipamọ sinu itura, gbigbẹ ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Di-tert-Butyl (2S,2'S) -2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di (1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) jẹ agbedemeji ti Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir (Daklinza) ti gba ipo “atunyẹwo akọkọ”, ni idapo pẹlu Sorafenib fun itọju genotype III awọn alaisan agbalagba ti o ni jedojedo onibaje C. Daklinza ti jẹ oogun akọkọ ti a ti fihan pe o munadoko ninu itọju genotype III ọlọjẹ jedojedo C. ikolu lai si ifowosowopo pẹlu interferon tabi ribavirin.Interferon ati Ribavirin jẹ awọn oogun meji ti FDA fọwọsi fun itọju ti ikolu arun jedojedo C.Hepatitis C jẹ arun ti o gbogun ti o le fa igbona ti ẹdọ, ti o mu ki iṣẹ ẹdọ dinku tabi ikuna ẹdọ.Pupọ awọn alaisan ti o ni arun jedojedo C ko ni awọn ami aisan titi ti ibajẹ ẹdọ yoo han, eyiti o le gba ọdun pupọ.Ni agbaye, genotype III jedojedo C jẹ keji ti o wọpọ julọ ti arun jedojedo C lẹhin genotype 1 jedojedo C ati pe a gba pe o jẹ ọkan ninu awọn arun genotype ti o ni itara julọ.Daklinza jẹ pan-genotype NS5A inhibitor isodipupo, pẹlu ipa ti idinamọ ti ẹda RNA ati apejọ gbogun ti, ipa antiviral meji.Fun awọn ẹkọ in vitro, Daklinza ti ṣe afihan lati ni ipa egboogi-viral lodi si genotype 1 ~ 6 ọlọjẹ jedojedo C.Daklinza wa pẹlu ikilọ pe apapọ amiodarone, Daklinza ati Sofosbuvir le fa idinku oṣuwọn ọkan ti o lagbara.Daklinza jẹ tabulẹti ẹnu pẹlu iwọn lilo ti a ṣe iṣeduro ti 60 miligiramu fun awọn akoko 1/d, ni apapo pẹlu Sofosbuvir fun apapọ ọsẹ mejila.
Iwadi ati ile-iṣẹ idagbasoke: Bristol-Myers Squibb.
Iwe itọsi: WO 2008021927A2 (August 9, 2007).
Akoko ti tita: July 24, 2015 akojọ si ni awọn United States, isowo orukọ Daklinza.
Awọn itọkasi: Ti a lo ni apapo pẹlu Sofosbuvir fun itọju genotype 3 onibaje jedojedo C (HCV) ikolu.
Ilana iṣe: HCV amuaradagba aiṣedeede 5A (NS5A) inhibitors.Awọn aati ikolu: awọn efori ati rirẹ.
Ilana ati awọn pato: Awọn tabulẹti, 30 ati 60mg.
