Risperidone CAS 106266-06-2 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Risperidone (CAS: 106266-06-2) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Risperidone,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Risperidone |
| Awọn itumọ ọrọ sisọ | 3-[2-[4- (6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl] ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1] ,2-a] pyrimidin-4-ọkan;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 106266-06-2 |
| Fọọmu Molecular | C23H27FN4O2 |
| Òṣuwọn Molikula | 410,49 g / mol |
| Ojuami Iyo | 170.0 si 174.0 ℃ |
| iwuwo | 1,38 ± 0,10 g / cm3 |
| Kíláàsì ewu | 6.1;Majele |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Awọn pato | Esi |
| Ifarahan | Funfun to Pa-White Powder | Ibamu |
| Idanimọ A | Gbigba infurarẹẹdi | Ibamu |
| Idanimọ B | Akoko Idaduro: Ni ibamu si nkan Itọkasi | Ibamu |
| Pipadanu lori Gbigbe | <0.50% | 0.12% |
| Aloku lori Iginisonu | <0.10% | 0.07% |
| Awọn irin Heavy | <0.001% | <0.001% |
| Awọn akojọpọ ibatan | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Eyikeyi Aimọ Aimọ | <0.10% | <0.10% |
| Lapapọ Awọn Aimọ | <0.30% | <0.30% |
| Ayẹwo | 98.0 ~ 102.0% (Iṣiro lori ipilẹ Gbẹ) | 100.52% |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu Standard USP 35 | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido [1,2-a] pyrimidin-4-ọkan, 3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) -1-piperidinyl] ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-ọkan [106266-06-2].
»Risperidone ko kere ju 98.0 ogorun ati pe ko ju 102.0 ogorun ti C23H27FN4O2, ṣe iṣiro lori ipilẹ ti o gbẹ.
Iṣakojọpọ ati ibi ipamọ- Ṣetọju ni awọn apoti ti o ni pipade daradara.Fipamọ ni iwọn otutu yara.
Awọn ajohunše Itọkasi USP <11>-
USP Risperidone RS
3- [2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-ọkan 410.48 CAS-106266-06-2
USP Risperidone System Ibamu Adalu RS
Ni ninu risperidone ati nipa 0.2% ti ọkọọkan awọn atẹle:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ọkan.
9-Hydroxyrisperidone- (6RS) -3- [2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ọkan.
6-Methylrisperidone- (6RS) -3- [2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ọkan.
[Akiyesi-Idapọ yii ni risperidone, Z-oxime, 9-hydroxyrisperidone, ati 6-methylrisperidone.]
Idanimọ-
A: Gbigba infurarẹẹdi <197K>.
B: Akoko idaduro ti tente oke pataki ni chromatogram ti igbaradi Assay ni ibamu si pe ninu chromatogram ti igbaradi Standard, bi a ti gba ni Assay.
Pipadanu lori gbigbe <731> - Gbẹ ni igbale ni 80 fun wakati mẹrin: ko padanu diẹ sii ju 0.5% ti iwuwo rẹ.
Aloku lori ina <281>: ko ju 0.1% lọ, apẹrẹ idanwo 2.0-g ti a lo.
Awọn irin ti o wuwo, Ọna II <231>: 0.001%.
Awọn akojọpọ ti o jọmọ-
Ojutu ifipamọ, Solusan A, Solusan B, Alakoso Alagbeka, Diluent, Ojutu ibamu eto, ati eto Chromatographic-Mura bi a ti ṣe itọsọna ni Assay.
Ojutu Boṣewa-Lo igbaradi Standard, pese sile bi a ti ṣe itọsọna ni Assay.
Idanwo ojutu-Lo Assay igbaradi.
Ilana-Tọ awọn iwọn dogba (bii 10 µL) ti ojutu Standard ati ojutu idanwo sinu chromatograph, ki o ṣe igbasilẹ chromatogram.Ṣe idanimọ awọn aimọ ni lilo awọn akoko idaduro ibatan ti a fun ni Tabili 1, ati wiwọn awọn idahun ti o ga julọ.Ṣe iṣiro ipin ipin kọọkan ti o ni ibatan risperidone ni apakan ti Risperidone ti o mu nipasẹ agbekalẹ:
100(CS/CU)(rU/rS)(1/F)
ninu eyiti CS ati CU jẹ awọn ifọkansi, ni mg fun milimita, ti risperidone ni ojutu Standard ati ojutu Idanwo lẹsẹsẹ;rU jẹ agbegbe ti o ga julọ ti aimọ kọọkan ti a gba lati inu ojutu Idanwo;rS jẹ agbegbe ti o ga julọ ti risperidone ti a gba lati ojutu Standard;ati F jẹ ifosiwewe idahun ojulumo fun aimọ aimọ kọọkan si risperidone.Ni afikun si ko kọja awọn opin ni Tabili 1, ko ju 0.10% ti aimọ eyikeyi ti aimọ (lilo F iye ti 1.0) ni a rii ati pe ko ju 0.30% ti awọn idoti lapapọ ni a rii.Fojusi awọn oke alaimọ ti o kere ju 0.05%.
Tabili 1
Àkókò Ìdánimọ́ Ìbátan Ìbápọ̀ Ìbápọ̀ (RRT) Opin Ìdáhùn Ìbátan (F) (%)
E-oxime1 0,60 1,0 NMT 0,20
Z-oxime2 0,67 0,63 NMT 0,20
9-hydroxyrisperidone3 0,76 0,92 NMT 0,20
5-fluororisperidone4 0,94 1,0 NMT 0,20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1,2 0,95 NMT 0,20
1 3- [2-[4- (E)-(2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido [1,2-a] pyrimidin-4-ọkan
2 3- [2-[4- (Z)-(2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H -pyrido [1,2-a] pyrimidin-4-ọkan
3 (9RS) -3- [2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ọkan
4 3-[2-[4- (5-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ọkan
5 (6RS) -3- [2-[4- (6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ọkan
Ayẹwo-
Ojutu ifipamọ- Tu 15.4 g ti ammonium acetate sinu 1 L ti omi.Ṣatunṣe pẹlu 10% acetic acid si pH ti 6.5, ati dapọ.
Solusan A-Dapọ 100 milimita ti ojutu Buffer pẹlu 150 milimita ti kẹmika ti kẹmika ninu ọpọn iwọn didun 1000-mL, ati dilute pẹlu omi si iwọn didun.
Solusan B- Illa 100 milimita ti ojutu Buffer pẹlu 850 milimita ti kẹmika ti methanol ninu ọpọn iwọn didun 1000-mL, ati dilute pẹlu omi si iwọn didun.
Alakoso Alagbeka-Lo awọn akojọpọ oniyipada ti Solusan A ati Solusan B gẹgẹbi a ti ṣe itọsọna fun eto Chromatographic.Ṣe awọn atunṣe ti o ba jẹ dandan (wo Ibaramu Eto labẹ Chromatography 621).
Diluent-Dapọ 100 milimita ti ojutu Buffer pẹlu 900 milimita ti omi ati 1000 milimita ti kẹmika.
Ojutu ìbójúmu eto-Mura 1 miligiramu fun ojutu milimita kan ti USP Risperidone System Suitability Mixture RS ni Diluent.
Standard igbaradi-tu ohun deede wọn opoiye ti USP Risperidone RS ni Diluent, ki o si dilute quantitatively, ati stepwise ti o ba wulo, pẹlu Diluent lati gba a ojutu nini a mọ fojusi ti nipa 1.0 miligiramu fun milimita.
Assay igbaradi-tu ohun deede iwon opoiye ti Risperidone ni Diluent, ki o si dilute quantitatively, ati stepwise ti o ba wulo, pẹlu Diluent lati gba a ojutu nini kan ifọkansi ti nipa 1.0 miligiramu fun milimita.
Eto Chromatographic (wo Chromatography <621>) - Kromatograph olomi ti ni ipese pẹlu aṣawari 275-nm ati iwe 4.6-mm × 10-cm ti o ni iṣakojọpọ 3-µm L1.Iwọn sisan jẹ nipa 1.5 milimita fun iṣẹju kan.Awọn iwọn otutu ọwọn ti wa ni itọju ni 35. Awọn chromatograph ti wa ni siseto gẹgẹbi atẹle.
Akoko (iṣẹju) Solusan A (%) Solusan B (%) Elution
0–1 70 30 isocratic
1–20 70®5 30®95 itesiwaju laini
20–25 5 95 isocratic
25–27 5®70 95®30 itesiwaju laini
27–35 70 30 tun-equilbrationGba ojutu ibaamu eto.Ṣe igbasilẹ awọn idahun ti o ga julọ bi a ti ṣe itọsọna fun Ilana, ki o ṣe idanimọ awọn giga julọ nitori Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, ati risperidone nipa lilo awọn akoko idaduro ibatan (RRT) lati Tabili 1;ipinnu, R, laarin Z-oxime ati 9-hydroxyrisperidone ko kere ju 2.8;ifosiwewe tailing fun risperidone ko ju 1.5 lọ;ati iyapa boṣewa ojulumo fun awọn abẹrẹ ẹda ko ju 2.0% fun tente oke risperidone.
Ilana- Lọtọ ara awọn ipele dogba (bii 10 µL) ti igbaradi Standard ati igbaradi Assay sinu chromatograph, ki o wọn awọn idahun fun tente oke risperidone.Ṣe iṣiro iye naa, ni ida ọgọrun ti C23H27FN4O2, ni apakan Risperidone ti o mu nipasẹ agbekalẹ:
100(CS/CU)(rU/rS)
ninu eyiti CS ati CU jẹ awọn ifọkansi, ni mg fun mL, ti risperidone ni igbaradi Standard ati igbaradi Assay, lẹsẹsẹ;ati rU ati rS jẹ awọn idahun ti o ga julọ ti a gba lati igbaradi Assay ati igbaradi Standard, lẹsẹsẹ.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Awọn koodu ewu R25 - Majele ti o ba gbe
R23/24/25 - Majele nipasẹ ifasimu, ni olubasọrọ pẹlu awọ ara ati ti o ba gbe.
R11 - Gíga flammable
Apejuwe Aabo S28 - Lẹhin olubasọrọ pẹlu awọ ara, wẹ lẹsẹkẹsẹ pẹlu ọpọlọpọ ọṣẹ-suds.
S36 - Wọ aṣọ aabo to dara.
S45 - Ni ọran ti ijamba tabi ti o ba ni ailara, wa imọran iṣoogun lẹsẹkẹsẹ (fi aami han nigbakugba ti o ṣee ṣe.)
S36/37 - Wọ aṣọ aabo ati awọn ibọwọ to dara.
S16 - Jeki kuro lati awọn orisun ti iginisonu.
UN ID 3249
WGK Germany 3
RTECS UV1164800
HS koodu 2934999099
Ewu Kilasi 6.1(a)
Iṣakojọpọ Ẹgbẹ II
Risperidone (CAS: 106266-06-2) ni ipa antagonism lori awọn olugba 5HT2 ati awọn olugba D2.A lo Risperidone fun schizophrenia nla ati onibaje.Awọn oogun antipsychotic.A lo Risperidone fun itọju ti schizophrenia nla ati onibaje ati ọpọlọpọ awọn ipo psychotic miiran ti o han awọn aami aiṣan rere (gẹgẹbi awọn hallucinations, iruju, rudurudu ero, ikorira, ifura) ati awọn aami aiṣan odi pataki (gẹgẹbi aibikita, aibalẹ ẹdun ati aibikita awujọ, ti diẹ awọn ọrọ).Paapaa o le dinku awọn aami aiṣan ti o ni nkan ṣe pẹlu schizophrenia (bii: ibanujẹ, ẹbi, aibalẹ).Fun awọn alaisan ti Risperidone jẹ doko si fun itọju nla, ni ipele itọju ti itọju, Risperidone le tẹsiwaju lati mu ipa ile-iwosan rẹ ṣiṣẹ.Risperidone, nitorinaa, ni iṣe itọju ailera lori mejeeji rere ati awọn ami aiṣedeede ti schizophrenia ati pe o ṣe agbejade awọn ipa ẹgbẹ diẹ ni pataki paapaa awọn ami aisan extrapyramidal ni akawe pẹlu awọn antipsychotics D2 antagonist funfun ti a lo nigbagbogbo.O tun ni agbara fun iṣakoso yiyọkuro oti ati afẹsodi kokeni.
