4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)
Shanghai Ruifu Kemikali jẹ olupese ti 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| Awọn itumọ ọrọ sisọ | 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo [b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Prucalopride Aimọ A;Prucalopride Succinate Aimọ-2 |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 123654-26-2 |
| Fọọmu Molecular | C9H8ClNO3 |
| Òṣuwọn Molikula | 213,62 g / mol |
| Ojuami Iyo | 242 ℃ (oṣu kejila) |
| Ojuami farabale | 406,5 ± 45,0 ℃ |
| iwuwo | 1.566 |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | Agbedemeji ti Prucalopride Succinate (CAS: 179474-85-2) |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Pa-White to Light-Pupa ri to | Light-Pupa ri to |
| Omi nipa Karl Fischer | ≤1.00% | 0.35% |
| Aloku lori Iginisonu | <0.20% | 0.08% |
| Awọn Irin Eru (Pb) | ≤20ppm | <10ppm |
| Aimọ Kanṣoṣo | ≤1.00% | Ibamu |
| Lapapọ Awọn Aimọ | ≤2.00% | Ibamu |
| Mimọ / Analysis Ọna | ≥98.0% (HPLC) | 99.6% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| 1 H NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Ọja yii jẹ 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, akoonu ti C12H12ClNO4 kii yoo kere ju 98.0%, iṣiro lori ipilẹ anhydrous.
[Awọn ohun-ini] Ọja yii jẹ funfun si ina-pupa ti o lagbara.
[Ṣayẹwo]
Mu iye ti o yẹ fun ọja yii (nipa 0.5g) ti omi, fi epo kun (methanol: N, N-dimethylformamide = 50:50), ki o si tu ni ibamu si ọna ipinnu omi (Afikun Ⅷ M, ọna akọkọ A).Lo idanwo Fisher silẹ lati pinnu titi ti ojutu yoo fi yipada lati ofeefee ina si pupa-pupa pupa ti n tọka aaye ipari, ati ṣe idanwo òfo miiran.Ṣe iṣiro ni ibamu si agbekalẹ atẹle: akoonu omi ko yẹ ki o kọja 1.00%.
Akoonu ọrinrin (%) = (AB) F/W×100%
Nibo, A jẹ iwọn didun omi Fisher ti o jẹ nipasẹ ọja idanwo (milimita);
B jẹ iwọn didun omi idanwo Fisher ti o jẹ nipasẹ aaye òfo, milimita;
F jẹ iwuwo ojutu idanwo Fisher deede si omi fun milimita 1, mg;
W jẹ iwuwo ọja idanwo, mg
Ohun elo ti o jọmọ
Gẹgẹbi ọna ti o wa labẹ “Nkan wiwọn akoonu”, ti o ba jẹ pe awọn oke alaimọkan wa ninu chromatogram ti ojutu idanwo, agbegbe tente oke ti aimọ kan ko ni tobi ju awọn akoko 10 (1.0%) ti agbegbe tente oke akọkọ ti iṣakoso. ojutu, ati apapọ agbegbe ti o ga julọ ti gbogbo awọn aimọ ko ni tobi ju awọn akoko 20 (2.0%) ti agbegbe tente oke akọkọ ti ojutu iṣakoso.
[Ipinnu Akoonu] Ni ibamu si iṣẹ ṣiṣe giga kiromatografi omi (Afikun VI D).
Octadecylsilane ti o ni asopọ silica gel jẹ lilo bi kikun fun awọn ipo kiromatogirafi ati awọn idanwo ibamu eto.Ojutu buffer Phosphate (1.36g potasiomu dihydrogen fosifeti, tituka ultrasonic ni omi 1L, phosphoric acid ti a ṣatunṣe si PH 3.0) ni a lo bi apakan alagbeka A. Acetonitrile jẹ apakan alagbeka B, ati elution gradient ni a ṣe ni ibamu si tabili atẹle:
Akoko (min) Alakoso alagbeka A alakoso alagbeka B
080 20
15 80 20
30 50 50
45 50 50
Gigun oju wiwa jẹ 254 nm.Iwọn sisan jẹ 1.0 milimita / min.Nọmba awọn abọ imọ-jinlẹ ko kere ju 2000 ni ibamu si oke ti 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Oke ti furanoformic acid ko kere ju 2000.
Ọna ipinnu:
Mu 10mg ti ọja idanwo naa, wọn ni deede, fi sinu igo 10ml, tu ultrasonic pẹlu apakan alagbeka A-mobile alakoso B (70:30) bi epo, dilute o si iwọn, gbọn daradara, ki o si mura kan ojutu pẹlu ifọkansi ti 1 miligiramu / milimita.20 l ti konge ti a itasi sinu chromatograph omi, ati awọn chromatogram ti a gba silẹ.Iwa mimọ tente akọkọ ko kere ju 98.0% ni ibamu si ọna isọdọtun agbegbe ti tente oke
Ọwọn: Dionex Acclaim C18, 4.6 * 250mm, 5um
Iwọn otutu: 40 ℃
Oṣuwọn sisan: 1.0ml/min
Wifulfulenti: 254nm
Iwọn apẹẹrẹ: 10μL
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), le ṣee lo bi agbedemeji fun iṣelọpọ ti Prucalopride Succinate (CAS: 179474-85-2), agonist olugba olugba 5-HT4 ti o yan ti a lo munadoko fun àìrígbẹyà onibaje.Prucalopride Succinate, dihydrobenzofurancarboxamide akọkọ-ni-kilasi, jẹ serotonin ti o yan (5-HT4) agonist olugba.Oogun naa, ti o ta ọja labẹ orukọ iyasọtọ Resolor®, ni iṣẹ ṣiṣe enterokinetic ati pe o jẹ idagbasoke nipasẹ ile-iṣẹ elegbogi ti o da lori Belijiomu Movetis.Prucalopride ṣe iyipada awọn ilana motility colonic nipasẹ serotonin 5-HT4 imudara olugba, ti nfa agbara ifasilẹ aarin fun igbẹgbẹ.
