2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Agbedemeji Mimọ>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ ti 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) pẹlu didara to gaju, agbedemeji Perampanel (CAS: 380917-97-5).Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra awọn agbedemeji Perampanel, Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Awọn itumọ ọrọ sisọ | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2- (1,3,2-Dioxaborinan-2-yl) benzonitrile |
| Nọmba CAS | 172732-52-4 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Ilana molikula | C10H10BNO2 |
| Òṣuwọn Molikula | 187.01 |
| Ojuami Iyo | 46.0 ~ 51.0 ℃ (tan.) |
| iwuwo | 1,13 ± 0,10 g / cm3 |
| Solubility | Tiotuka ni kẹmika |
| Iduroṣinṣin | Hygroscopic |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun to Light Yellow lulú to Crystal |
| Mimọ / Analysis Ọna | > 99.0% (HPLC) |
| Pipadanu lori Gbigbe | <0.50% |
| Aloku lori Iginisonu | <0.20% |
| Nikan Aimọ | <0.50% |
| Lapapọ Awọn Aimọ | <1.00% |
| Awọn irin Heavy (gẹgẹbi Pb) | <20ppm |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Agbedemeji ti Perampanel (CAS: 380917-97-5) |
Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.
Awọn aami ewu Xi - Irritant
Awọn koodu ewu
R20/21/22 - Ipalara nipasẹ ifasimu, ni olubasọrọ pẹlu awọ ara ati ti o ba gbe.
R36 / 37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Abo
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S36/37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju.
UN ID 3439
WGK Germany 3
TSCA No
Akọsilẹ ewu Irritant
2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) ni a lo ninu iṣelọpọ ti Perampanel (CAS: 380917-97-5), antagonist olugba AMPA kan.Perampanel (asẹ ni 2012) jẹ iran-kẹta AED ti a mọ pẹlu orukọ ami iyasọtọ ti Fycompa® (Eisai, Hatfield) ni UK ati Banzel® (Eisai, Hatfield) ni AMẸRIKA.Ni Oṣu Kẹwa Ọdun 2012, US FDA fọwọsi perampanel fun itọju awọn ikọlu ibẹrẹ apakan ni awọn alaisan warapa ti o kere ju ọdun 12 ọdun.Perampanel jẹ alatako olugba olugba AMPA akọkọ lati gba ifọwọsi FDA bi AED.Awọn olugba AMPA glutamate ni a rii ni akọkọ lori awọn neuronu postsynaptic ninu ọpọlọ.Gẹgẹbi yiyan, antagonist ti ko ni idije ti AMPA, parampanel ṣe idiwọ ṣiṣi ikanni ion ati dinku itankale agbara iṣe.Perampanel ti fọwọsi nipasẹ European EMA ati US FDA ni Oṣu Keje ati Oṣu Kẹwa Ọdun 2012 ni atele, o jẹ lilo fun itọju adjuvant ti awọn alaisan ti o ni awọn ikọlu apa kan ju ọdun 12 lọ pẹlu tabi laisi awọn ikọlu eto eto keji.Ni Oṣu Karun ọjọ 22, Ọdun 2015, Eisai kede pe US FDA ti fọwọsi imugboroja ti itọkasi Pirenparanide hydrate (Fycompa) gẹgẹbi itọju adjuvant fun awọn ijagba tonic-clonic akọkọ ni awọn alaisan pẹlu warapa ti ọjọ ori 12 ati loke.
