3-Chloro-4- (3-Fluorobenzyloxy) aniline CAS 202197-26-0 Lapatinib Intermediate Purity> 98.0% (HPLC)
Shanghai Ruifu Kemikali Co., Ltd jẹ olupese ti 3-Chloro-4- (3-Fluorobenzyloxy) aniline (CAS: 202197-26-0) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Lapatinib Intermediates,Please contact: alvin@ruifuchem.com
Orukọ Kemikali | 3-Chloro-4- (3-Fluorobenzyloxy) aniline |
Awọn itumọ ọrọ sisọ | 3-Chloro-4- [(3-Fluorophenyl) methoxy] aniline;4- (3-Fluorobenzyloxy) -3-Chlorobenzenamine;Lapatinib Intermediate B |
Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
Nọmba CAS | 202197-26-0 |
Fọọmu Molecular | C13H11ClFNO |
Òṣuwọn Molikula | 251,69 g / mol |
Ojuami Iyo | 78.0 si 82.0 ℃ |
iwuwo | 1.306 ± 0,06 g / cm3 |
COA & MSDS | Wa |
Apeere | Wa |
Ipilẹṣẹ | Shanghai, China |
Brand | Ruifu Kemikali |
Awọn nkan | Ayewo Standards | Esi |
Ifarahan | Brown to Black Powder | Ibamu |
Ojuami Iyo | 78.0 si 82.0 ℃ | 80.7 ℃ |
Pipadanu lori Gbigbe | <1.00% | Ibamu |
Aloku lori Iginisonu | <0.50% | Ibamu |
Jẹmọ impurities nipa HPLC | <2.00% | 0.64% |
Mimọ / Analysis Ọna | > 98.0% (HPLC) | 99.36% |
1H NMR julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
Ohun elo | Agbedemeji ti Lapatinib / Lapatinib Ditosylate Monohydrate |
Apo:Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati fipamọ sinu itura, gbigbẹ ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
UN ID 3077
HS koodu 2921420090
Ewu Kilasi 9
Iṣakojọpọ Ẹgbẹ III
3-Chloro-4- (3-Fluorobenzyloxy) aniline (CAS: 202197-26-0) jẹ agbedemeji ninu iṣelọpọ ti Lapatinib / Lapatinib Ditosylate Monohydrate.
Lapatinib jẹ oogun ti o fojusi akàn igbaya ti o ni idagbasoke nipasẹ Ilu Gẹẹsi GlaxoSmithKline Co. Awọn olugba ErbB Human ErbB jẹ ti idile olugba I tyrosine kinase (TK), pẹlu ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), ati ErbB4 (HER4) .Awọn olugba ErbB-1 (EGFR) ati ErbB-2 (HER-2) jẹ igbagbogbo pupọju tabi bibẹẹkọ yipada ninu awọn alaisan alakan.Olugba ifosiwewe idagba eniyan epidermal 2 (ErbB-2, HER-2) ni a mọ lati jẹ onkogene eniyan ti o ni ibatan pẹkipẹki pẹlu alakan igbaya.Ikosile giga rẹ ni akàn igbaya nigbagbogbo n sọ asọtẹlẹ metastasis apa iho-ara ati iyatọ tumo ti ko dara, pẹlu asọtẹlẹ ti ko dara.HER-2 jẹ ọkan ninu awọn moleku ibi-afẹde fun itọju ailera kan-akàn igbaya.Lapatinib le ṣiṣẹ ni nigbakannaa lori mejeeji Her-1 Her-2.Awọn ipa ti ibi-ara ti ọna yii ti o dẹkun ilọsiwaju ati idagbasoke ti awọn sẹẹli tumo jẹ tobi pupọ ju ṣiṣe nikan ni ibi-afẹde kan.Apapo Lapatinib pẹlu Capecitabine ni a lo lati ṣe itọju awọn alaisan ti o ni ilọsiwaju tabi aarun igbaya igbaya metastatic ti o pọju ti olugba eniyan epidermal receptor2, ti a ti tọju tẹlẹ pẹlu anthracyclines, paclitaxel, ati trastuzumab.Awọn idanwo ile-iwosan ti fihan pe Lapatinib tun ṣe itọju awọn alaisan akàn iru HER2 pẹlu imunadoko Herceptin.