Vardenafil Intermediate CAS 224789-21-3 Mimọ> 99.0% (HPLC)
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ti 2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F] [1,2,4] triazin-4 (3H) -ọkan (CAS: 224789-21-3) pẹlu didara to gaju, agbedemeji ti Vardenafil.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F][1,2,4]triazin-4 (3H) -ọkan |
| Awọn itumọ ọrọ sisọ | Vardenafil Dessulfonyl Aimọ;2- (2-Ethoxyphenyl) -5-Methyl-7-Propyl-3H-Imidazo [5,1-F] [1,2,4] triazin-4-ọkan;Vardenafil Propyl Imidazotriazinone Aimọ;Agbo ti o jọmọ Vardenafil 1 |
| Iṣura Ipo | Ninu Iṣura, Agbara iṣelọpọ 2 Toonu fun oṣu kan |
| Nọmba CAS | 224789-21-3 |
| Fọọmu Molecular | C17H20N4O2 |
| Òṣuwọn Molikula | 312,37 g / mol |
| Ojuami Iyo | 142.0 ~ 148.0 ℃ |
| iwuwo | 1,26 ± 0,10 g / cm3 |
| Ibi ipamọ igba pipẹ | Itura & Ibi Gbẹ (2 ~ 8℃) |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Awọn pato | Esi |
| Ifarahan | Pa-White to Bia Yellow Powder | Pa-White Powder |
| Ojuami Iyo | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Pipadanu lori Gbigbe | <1.00% (102℃, 3h) | 0.23% |
| Awọn Irin Eru (Pb) | ≤20ppm | <20ppm |
| Mimọ / Analysis Ọna | > 99.0% (HPLC) | 99.79% |
| 1H NMR julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
| Ohun elo | Agbedemeji ti Vardenafil / Vardenafil Hydrochloride | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati orun ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
1. Irisi: Fi ayẹwo naa sori iwe funfun ati ki o ṣe akiyesi irisi, ni pipa-funfun si iyẹfun awọ-ofeefee.
2. Itupalẹ:
2.1 Ipinnu Oju Iyọ ni ibamu si ofin (Pharmacopoeia ti Ilu Kannada 2010 Edition II Afikun ⅥC) Aaye yo jẹ 142.0 ~ 148.0℃.
2.2 Pipadanu lori Gbigbe: Ipinnu gẹgẹbi ofin (Afikun ⅧL, Apá II, 2010 Edition of Chinese Pharmacopoeia).Iwọn iwọn deede ti ọja yii, gbẹ ni 102 ℃ fun awọn wakati 3, pipadanu iwuwo kii yoo ju 1.00%.
2.3 Awọn irin Heavy: Ipinnu gẹgẹbi ofin (Orilẹ-ede Republic of China Pharmacopoeia 2010 Edition, Apá II Àfikún ⅧH) Ipinnu nipasẹ ọna keji.
Iwọn deede 1.0g ti ọja idanwo, sisun laiyara titi di carbonized patapata, dara, fi 0.5-1.0ml sulfuric acid, jẹ ki o tutu, ooru ni iwọn otutu kekere titi ti sulfuric acid yoo fi rẹwẹsi, fi 0.5ml nitric acid, nya gbẹ, titi Omi afẹfẹ nitrogen ti re, itura, gbona ni 500-600 ℃ si carbonized patapata, dara, ṣafikun 2ml hydrochloric acid, Lẹhin gbigbe ninu iwẹ omi kan, ṣafikun omi 15ml, ju ojutu idanwo amonia silẹ titi o fi di didoju si itọkasi phenolphthalein ojutu, fi 2ml acetate buffer (ph3.5), ati die-die ooru tu, gbe lọ si Nachner colorimetric tube, ki o si dilute o sinu 25ml pẹlu omi.Mu reagent miiran fun igbaradi ojutu idanwo, ki o tan sinu satelaiti tanganran, ṣafikun 2ml acetate buffer (PH3.5) ati omi 15ml si ooru diẹ Lẹhin itusilẹ, gbe tube Nath colorimetric tube, ṣafikun iye kan ti ojutu asiwaju boṣewa, ati lẹhinna di dilute pẹlu omi si 25ml.Ayẹwo awọ-ara ni a ṣe laarin ojutu idanwo ati ojutu boṣewa lati gba.Standard ojutu igbaradi ni ibamu si (People's Republic of China Pharmacopoeia 2010 àtúnse II Àfikún Ⅷ Heavy irin igbeyewo ọna) akọkọ ọna.Awọn irin ti o wuwo ko gbọdọ kọja awọn ẹya 20 fun miliọnu kan.
3. Ti nw: Ni ibamu si ga iṣẹ-giga chromatography omi, pinnu gẹgẹ bi ofin (Chinese Pharmacopoeia 2010 àtúnse II Àfikún VD).
Awọn ipo Chromatographic:
Ọwọn: C18, 200mm × 4.6mm, 5μm;
Ipele alagbeka: Ifipamọ Phosphate (ṣe iwọn 2.72g potasiomu dihydrogen fosifeti, fi omi kun lati tu ati dilute si 1000ml, ṣatunṣe pH=3.5) : acetonitrile: = 35:65;
Gigun wiwa: 254nm;
Oṣuwọn sisan: 1.0ml/min.
Ọna ipinnu: Mu nipa 30mg ti ọja yii, ṣe iwọn rẹ ni deede, dilute rẹ pẹlu apakan alagbeka lati ṣe ifọkansi ti 0.3mg/milimita, mu 20μl sinu chromatograph omi, ṣe igbasilẹ chromatogram naa.Gẹgẹbi ọna deede agbegbe, mimọ ko kere ju 99.0%.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F][1,2,4]triazin-4 (3H) -ọkan (CAS: 224789-21-3) jẹ agbedemeji ti Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil jẹ inhibitor PDE5 tuntun ti a ṣe ifilọlẹ fun itọju ẹnu ti aiṣedeede erectile ọkunrin ati pe o ni ibajọra igbekalẹ pataki pẹlu sildenafil (Viagra), eyiti o jẹ inhibitor PDE5 akọkọ ti a ṣe ni 1998 fun itọkasi yii.
Vardenafil jẹ aṣoju keji lati wa ni tita ati pe o ni anfani pe akoko ibẹrẹ rẹ ko dinku nipasẹ gbigbe oogun naa ni ikun ni kikun.O jẹ awọn akoko 30 diẹ sii bi oludaniloju PDE5 (tumọ si IC50, 3.9 nM) ju sildenafil ati awọn akoko 10 diẹ sii ju tadalafil lọ, pẹlu yiyan ti o tobi ju (> 1,000 igba) fun eniyan PDE5 ju fun eniyan PDE2, PDE3, ati PDE4 ati yiyan yiyan (> 80 igba) fun PDE1.Aṣayan inhibitory PDE ati mejeeji in vitro ati agbara in vivo ti inhibitor PDE5 tuntun vardenafil.Vardenafil ṣe pataki ni idiwọ hydrolysis ti cGMP nipasẹ PDE5, pẹlu IC50 ti 0.7 nM (sildenafil 6.6 nM).IC50 ti vardenafil fun PDE1 jẹ 180 nM, fun PDE6 11 nM, ati fun PDE2, PDE3 ati PDE4 diẹ sii ju 1,000 nM.
