Ipilẹ Lapatinib CAS 231277-92-2 Mimọ ≥99.0% (HPLC)

Apejuwe kukuru:

Orukọ Kemikali:Lapatinib Ipilẹ

CAS: 231277-92-2

Mimọ: ≥99.5% (HPLC)

Fere Funfun tabi Ina Yellow Crystalline Powder

Olubasọrọ: Dokita Alvin Huang

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E-Mail: alvin@ruifuchem.com

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Lapatinib Intermediates:

Lapatinib Ipilẹ	CAS 231277-92-2
Lapatinib Ditosylate Monohydrate	CAS 388082-78-8
Iṣuu soda Methanesulfinate	CAS 20277-69-4
3-Chloro-4- (3-Fluorobenzyloxy) aniline	CAS 202197-26-0
2-Aminoethyl Methyl Sulfone Hydrochloride	CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	CAS 98556-31-1
6-Iodo-4-Hydroxyquinazoline	CAS 16064-08-7
5-Formyl-2-Furanboronic Acid	CAS 27329-70-0
5-[4-[3-Chloro-4- (3-Fluorobenzyloxy) anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	CAS 231278-84-5

Kemikali Properties:

Orukọ Kemikali	Lapatinib Ipilẹ
Awọn itumọ ọrọ sisọ	Lapatinib;N-[3-Chloro-4-[(3-fluorobenzyl) oxy] phenyl] -6-[5-[[(2- (methylsulfonyl) ethyl]amino] methyl]furan-2-yl] quinazolin-4-amine ; N-[3-Chloro-4-[(3-fluorobenzyl) oxy] phenyl] -6-[5-[[2- (methylsulfonyl) ethyl] amino] methyl] -2-furyl] -4-quinazolinamine
Nọmba CAS	231277-92-2
Iṣura Ipo	O wa
Fọọmu Molecular	C29H26ClFN4O4S
Òṣuwọn Molikula	581.06
Ojuami Iyo	141.0 ~ 149.0 ℃
iwuwo	1,381 ± 0,06 g / cm3
COA & MSDS	Wa
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Fere Funfun tabi Ina Yellow Crystalline Powder
Idanimọ	IR;HPLC
Mimọ / Analysis Ọna	≥99.0% (HPLC)
Ojuami Iyo	141.0 ~ 149.0 ℃
Pipadanu lori Gbigbe	≤0.50%
Aloku lori Iginisonu	≤0.10%
Awọn irin Heavy (gẹgẹbi Pb)	≤20ppm
Organic Iyipada impurities	Pade Awọn ibeere
Awọn nkan ti o jọmọ
Aimọ Kanṣoṣo	≤0.30%
Lapapọ Awọn Aimọ	≤1.00%
Igbeyewo Standard	Standard Enterprise
Igbesi aye selifu	Awọn ọdun 2 Nigbati Ti fipamọ daradara
Lilo	API, Itọju Ẹnu fun Akàn Ọyan

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

231277-92-2 - Ohun elo:

API (CAS: 231277-92-2)jẹ itọju ti a fojusi ti oogun aarun igbaya igbaya, jẹ inhibitor tyrosine kinase, o le ṣe idiwọ imunadoko olugba idagbasoke idagbasoke eniyan -1 (ErbB1) ati olugba idagba ifosiwewe idagba eniyan (ErbB2) iṣẹ tyrosine kinase ti -2.O jẹ alailẹgbẹ ni pe o le ṣe ipa ni awọn ọna oriṣiriṣi, ki awọn sẹẹli alakan igbaya ko le gba ifihan agbara ti o nilo fun idagbasoke.Ilana ti iṣe ni lati ṣe idiwọ EGFR intracellular (ErbB-1) ati HER2 (ErbB-2) awọn aaye ATP lati ṣe idiwọ phosphorylation ati ṣiṣiṣẹ ti awọn sẹẹli tumo, ati lati ṣe idiwọ ilana-isalẹ ti ifihan nipasẹ EGFR (ErbB-1) ati HER2 (ErbB-1) isokan ati orisirisi awọn akojọpọ meji.Apapo ti (CAS: 231277-92-2) pẹlu Capecitabine ni a lo lati ṣe itọju awọn alaisan ti o ni ilọsiwaju tabi aarun igbaya igbaya metastatic pẹlu overexpression ti eda eniyan epidermal receptor2, ti a ti tọju tẹlẹ pẹlu anthracyclines, paclitaxel, ati trastuzumab.Awọn idanwo ile-iwosan ti fihan pe o tun ṣe itọju awọn alaisan alakan iru HER2 pẹlu imunadoko Herceptin.

231277-92-2 - Awọn itọkasi:

Lapatinib ni apapo pẹlu Capecitabine jẹ o dara fun itọju awọn alaisan ti o ni ilọsiwaju tabi metastatic igbaya aarun igbaya pẹlu HER2 (ErbB-2 overexpression) ati itọju iṣaaju pẹlu anthracyclines, paclitaxel ati trastuzumab.

231277-92-2 - Oògùn Ibaṣepọ:

Awọn tabulẹti Lapatinib in vitro le ṣe idiwọ CYP3A4 ati CYP2C8 ni awọn ifọkansi ti itọju ailera, ati pe o jẹ iṣelọpọ nipataki nipasẹ CYP3A4.awọn oogun ti o ṣe idiwọ iṣẹ ṣiṣe henensiamu le ṣe alekun ifọkansi oogun ẹjẹ ti Lapatinib ni pataki.Ketoconazole, 0.2g kọọkan akoko, 2 igba / d, le mu awọn AUC ti Lapatinib nipa 3 ~ 7 igba ati ki o fa awọn idaji-aye nipa 1.7 igba lẹhin 7 ọjọ.Awọn oluyọọda ti o ni ilera mu inducer CYP3A4 ni ẹnu, 100 miligiramu ni akoko kọọkan, lẹmeji ọjọ kan, ati yipada si 200mg ni akoko kọọkan lẹhin awọn ọjọ 3, pinpin awọn ọjọ 17 lẹmeji ọjọ kan.AUC ti Lapatinib dinku nipasẹ 72%.Lapatinib jẹ ilẹ gbigbe fun P-glycoprotein, ati awọn oogun ti o ṣe idiwọ glycoprotein le mu ifọkansi ẹjẹ ti oogun naa pọ si.

Oogun Tuntun fun Itọju Ifojusi ti Akàn Ọyan:

Lapatinib jẹ oogun tuntun fun itọju aifẹ ti akàn igbaya ti o dagbasoke nipasẹ GlaxoSmithKline, UK.O jẹ onidalẹkun tyrosine kinase ti o le ṣe idiwọ imunadoko eniyan ti o ni ipa-idagba idagba eniyan -1 (ErbB1) ati olugba idagba ifosiwewe idagba eniyan -2 (ErbB2) iṣẹ ṣiṣe tyrosine kinase.O jẹ alailẹgbẹ ni pe o le ṣiṣẹ ni awọn ọna oriṣiriṣi ki awọn sẹẹli alakan igbaya ko le gba awọn ifihan agbara ti o nilo fun idagbasoke.Ilana ti iṣe ni lati ṣe idiwọ awọn aaye ATP ti EGFR (ErbB-1) ati HER2 (ErbB-2) ninu awọn sẹẹli lati ṣe idiwọ phosphorylation ati ṣiṣiṣẹ ti awọn sẹẹli tumo, ati dena awọn ifihan agbara-isalẹ nipasẹ isokan ati awọn dimers oriṣiriṣi ti EGFR (ErbB) -1) ati HER2 (ErbB-1).Itọju ifọkansi molikula fun akàn igbaya n tọka si itọju awọn oncogenes ati awọn ọja ikosile ti o ni ibatan si iṣẹlẹ ati idagbasoke ti akàn igbaya.Awọn oogun ìfọkànsí molikula ṣe idiwọ tabi pa awọn sẹẹli tumo nipa didina ifihan ifihan ninu awọn sẹẹli tumo tabi awọn sẹẹli ti o jọmọ lati ṣakoso awọn iyipada ninu ikosile jiini sẹẹli.ni Oṣu Kẹta Ọjọ 14, Ọdun 2007, iṣakoso ounjẹ ati oogun AMẸRIKA fọwọsi apapo lapatinib ati xeloda (capecitabine) fun itọju awọn alaisan alakan igbaya ti o ti ni ilọsiwaju tabi metastatic ti o pọju nipasẹ olugba eniyan epidermal ifosiwewe 2 (ErbB2) ati mu pẹlu anthracyclines, paclitaxel ati trastuzumab. .Awọn idanwo ile-iwosan fihan pe ọja yii tun ni awọn ipa ile-iwosan to dara fun awọn alaisan akàn igbaya HER2 ti o ti ni idagbasoke oogun oogun si Roche's Herceptin (Herceptin).lapatinib jẹ oogun akàn ti a fojusi tuntun.O le ṣiṣẹ lori awọn ibi-afẹde Her-1 ati Her-2 ni akoko kanna.Ipa ti ẹda ti ipo iṣe yii lori ilọsiwaju ati idagbasoke ti awọn sẹẹli tumo jẹ eyiti o tobi ju ti ibi-afẹde kan ṣoṣo lọ.Ohun ti a npe ni awọn oogun oogun ti a fojusi tọka si awọn oogun ti o lo awọn olugba kan, awọn jiini tabi awọn ọlọjẹ bọtini bi awọn ibi-afẹde lati pa awọn sẹẹli tumo ti o ni ibatan ni ọna ti a fojusi.