Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl) hydrazono] acetate Purity ≥99.0% (HPLC)

Apejuwe kukuru:

Ethyl Chloro[(4-Methoxyphenyl)hydrazono] acetate

CAS: 27143-07-3

Mimọ: ≥99.0% (HPLC)

Irisi: Imọlẹ Yellow to Yellow Powder

Agbedemeji ti Apixaban (CAS: 503612-47-3)

Olubasọrọ: Dokita Alvin Huang

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E-Mail: alvin@ruifuchem.com


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Apejuwe:

Ruifu Kemikali jẹ oludari asiwaju ti Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) pẹlu didara to gaju, agbedemeji ti Apixaban (CAS: 503612-47-3).Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, kekere ati awọn iwọn olopobobo ti o wa.Ra Apixaban agbedemeji, E-mail: alvin@ruifuchem.com

Apixaban Intermediates:

Kemikali Properties:

Orukọ Kemikali Ethyl Chloro[(4-Methoxyphenyl)hydrazono] acetate
Awọn itumọ ọrọ sisọ Ethyl 2-Chloro-2- [2- (4-Methoxyphenyl) hydrazono] acetate;(Z) -Ethyl 2-Chloro-2- (2- (4-Methoxyphenyl) hydrazono) acetate;2-Chloro-2- [2- (4-Methoxyphenyl) hydrazinylidene];Apixaban-2;Apixaban aimọ 3
Iṣura Ipo Ni Iṣura, Iṣowo Iṣowo
Nọmba CAS 27143-07-3
Fọọmu Molecular C11H13ClN2O3
Òṣuwọn Molikula 256,69 g / mol
Ojuami Iyo 94℃
iwuwo 1.23
COA & MSDS Wa
Ipilẹṣẹ Shanghai, China
Ẹka Agbedemeji ti Apixaban (CAS: 503612-47-3)
Brand Ruifu Kemikali

Awọn pato:

Awọn nkan Ayewo Standards Esi
Ifarahan Ina Yellow to Yellow Powder Ibamu
Pipadanu lori Gbigbe <0.50% 0.23%
Mimọ / Analysis Ọna ≥99.0% (HPLC) 99.3%
Infurarẹẹdi julọ.Oniranran Ni ibamu si Eto Ibamu
1 H NMR julọ.Oniranran Ni ibamu pẹlu Eto Ibamu
Ipari Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun

Package/Ipamọ/Gbigbe:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

27143-07-3 - Ona Sintetiki:

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Akojọ ti awọn ohun elo ti a lo ninu iṣelọpọ

Rara. Oruko CAS No. Fọọmu Molecular
1 Ethyl acetate CAS: 141-78-6 C4H8O2
2 Dichloromethane CAS: 75-09-2 CH2Cl2
3 Ethyl Ọtí CAS: 64-17-5 C2H5OH

27143-07-3 - Ọna idanwo:

5.3.1 Irisi: O yẹ ki o jẹ ina ofeefee to ofeefee lulú.Ni oju, dubulẹ iye ọja idanwo to to (laisi iwọn) ninu satelaiti gara mimọ lori ipilẹ funfun kan (bii iwe funfun) labẹ ina adayeba.
5.3.2 Idanimọ: 1H-NMR ni o ni kanna be bi bošewa.10 ~ 15mg ti ayẹwo ni a ṣe iwọn sinu tube magnetic iparun, ati 0.5mL ti deuterium DMSO ni a fi kun lati tu ayẹwo naa ni kikun, ati lẹhinna ni idanwo pẹlu ohun elo imudani ti o pọju ti 400MHz.
5.3.3 Pipadanu lori gbigbe: Ṣe iwọn ayẹwo nipa 1.0g ki o gbẹ fun 3h ni adiro gbigbe ni 85 ℃.Iṣiṣẹ kan pato fun iṣiro pipadanu iwuwo yoo ṣee ṣe ni ibamu si awọn ipese ti SOP-AP-QC-002-01 fun Ipinnu Ipadanu iwuwo Gbigbe.
5.3.4.1 Awọn ipo Chromatographic:
Awọn atunda idanwo: 1) acetonitrile fun chromatography 2) omi mimọ 3) phosphoric acid
Ọwọn: WondaCrac ODS-2 4.6*250mm*5um (8520-39993)
Ipele alagbeka: A: Iwọn deede 1.0ml phosphoric acid ati omi 1000ml, àlẹmọ ultrasonic degassing.
B: Acetonitrile.
Ilana Gradient: tabili atẹle
Akoko alagbeka alakoso A (%) Alagbeka ipele B (%)
390 10
10 25 75
200 100
25 0100
Awari: 210nm
Iwọn otutu: 35 ℃
Iyara sisan: 1.0ml/min
Iwọn apẹẹrẹ: 5µl
5.3.4.2 Igbaradi ojutu:
5.3.4.3 diluent: acetonitrile
5.3.4.4 Òfo ojutu: diluent li ao lo bi òfo ojutu.
5.3.4.5 Idanwo ojutu ọja: Ṣe iwọn ọja idanwo nipa 12.5mg ni igo 25ml volumetric kan ati ki o tu pẹlu diluent si iwọn.
5.3.4.6 Ilana iṣiṣẹ: Lẹhin ipilẹ ipilẹ ti ohun elo jẹ iduroṣinṣin, ọkan si meji awọn abẹrẹ ti ojutu òfo ti ni ilọsiwaju, lẹhinna ojutu ti ọja idanwo jẹ itupalẹ.chromatogram ti wa ni fipamọ ati atupale, a yọkuro tente oke ofo, ati mimọ tente oke akọkọ ati awọn abajade aimọ ẹyọkan lori chromatogram ti ọja idanwo naa ni a gbasilẹ nipasẹ ọna isọdọtun agbegbe.Lẹhin itupalẹ, a ti tẹ chromatogram naa.

Awọn anfani:

Agbara to to: Awọn ohun elo to ati awọn onimọ-ẹrọ

Iṣẹ Ọjọgbọn: Iṣẹ rira iduro kan

OEM Package: Aṣa package ati aami wa

Ifijiṣẹ Yara: Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta

Ipese Idurosinsin: Ṣetọju ọja iṣura ti o tọ

Atilẹyin imọ-ẹrọ: Ojutu imọ-ẹrọ wa

Iṣẹ Iṣọkan Aṣa: Larin lati giramu si kilos

Didara to gaju: Ṣeto eto idaniloju didara pipe

FAQ:

Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.

Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.

Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.

DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl

Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.

Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.

MOQ?Ko si MOQ.Ibere ​​kekere jẹ itẹwọgba.

Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.

Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.

Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.

Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.

Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.

Ohun elo:

Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) ni a lo gẹgẹbi agbedemeji ni iṣelọpọ ti Apixaban (CAS: 503612-47-3).Apixaban jẹ oriṣi tuntun ti ifosiwewe ẹnu ẹnu Xa inhibitor ni apapọ nipasẹ Bristol-Myers Squibb ati Pfizer.Orukọ iṣowo jẹ Erroto.O jẹ iru tuntun ti anticoagulant ẹnu.Nipa idinamọ ifosiwewe coagulation pataki Xa, apixaban le ṣe idiwọ iṣelọpọ thrombin ati thrombosis.Apixaban ni idagbasoke nipasẹ Bristal-Myers squibb Company.O ni o dara bioavailability ati ki o ga selectivity.A ṣe akojọ rẹ ni Ilu China ni ọdun 2013. Apixaban jẹ ailewu, o ṣeeṣe ti ibaraenisepo oogun jẹ kekere, ati pe awọn ọna pupọ wa lati yọkuro rẹ, eyiti a nireti lati lo ni awọn ẹgbẹ pataki ti o jiya lati arun ẹdọ tabi ibajẹ iṣẹ kidinrin.

Kọ ifiranṣẹ rẹ nibi ki o si fi si wa