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Ibrutinib Intermediate CAS 330792-70-6 Mimo> 98.0% (HPLC) Aworan ti o ni ifihan
  • Ibrutinib Intermediate CAS 330792-70-6 Mimọ>98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Mimọ>98.0% (HPLC)

Apejuwe kukuru:

5-Amino-3- (4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Mimọ:> 98.0% (HPLC)

Irisi: Pa-White to Light Yellow Powder

Agbedemeji ti Ibrutinib (CAS: 936563-96-1) 

Olubasọrọ: Dokita Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Awọn agbedemeji ti Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S) -1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo [3,4-d] pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d] pyrimidine CAS 151266-23-8
Ibrutinib Deacryloylpiperidine CAS 330786-24-8
5-Amino-3- (4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Kemikali Properties:

Orukọ Kemikali 5-Amino-3- (4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Awọn itumọ ọrọ sisọ Ibrutinib Intermediate N-3;3-Amino-5- (4-Phenoxyphenyl) pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5- (4-Phenoxyphenyl) pyrazole;5-Amino-3- (4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Nọmba CAS 330792-70-6
Iṣura Ipo Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Ilana molikula C16H12N4O
Òṣuwọn Molikula 276.29
iwuwo 1,37 ± 0,10 g / cm3
COA & MSDS Wa
Ipilẹṣẹ Shanghai, China
Brand Ruifu Kemikali

Awọn pato:

Nkan Awọn pato
Ifarahan Pa-White to Light Yellow Powder
Mimọ / Analysis Ọna > 98.0% (HPLC)
Pipadanu lori Gbigbe <1.00%
Aloku lori Iginisonu <0.50%
Lapapọ Awọn Aimọ <2.00%
Awọn irin Heavy (gẹgẹbi Pb) <20ppm
1 H NMR julọ.Oniranran Ni ibamu pẹlu Eto
Igbeyewo Standard Standard Enterprise
Lilo Agbedemeji ti Ibrutinib (CAS: 936563-96-1)

Package & Ibi ipamọ:

Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.

Awọn anfani:

1

FAQ:

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330792-70-6 - Ohun elo:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) jẹ agbedemeji ti Ibrutinib (CAS: 936563-96-1).Ibrutinib ṣe afihan ipa inhibitory ti o lagbara ati ti ko le yipada ati yiyan fun iṣẹ enzymatic Btk.Ni laini sẹẹli DOHH2 ti BCR ti mu ṣiṣẹ, Ibrutinib ṣe idiwọ autophosphorylation ti Btk, phosphorylation ti Btk's physiological substrate PLCγ, ati phosphorylation ti kinase sisale siwaju, ERK pẹlu IC50 ti 11 nM, 29 nM ati 13 nM lẹsẹsẹ.Ibrutinib ṣe afihan iwọn-iwọn lilo pataki ati ifakalẹ ti o gbẹkẹle akoko ti cytotoxicity ninu awọn sẹẹli lymphocytic onibaje (CLL).Ni afikun, Ibrutinib nfa iku sẹẹli da lori imuṣiṣẹ ipa ọna caspase ati atako agbara ti awọn sẹẹli CLL lati pọsi lẹhin ifihan TLR.

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