CAS 361442-04-8 Mimo>99.0% (HPLC) API Aworan Ifihan

CAS 361442-04-8 Mimọ>99.0% (HPLC) API

Apejuwe kukuru:

Awọn itumọ ọrọ: BMS-477118;Onglyza

CAS: 361442-04-8

Mimọ:> 99.0% (HPLC)

Irisi: White Powder

API, Didara Giga, Ṣiṣejade Iṣowo

E-Mail: alvin@ruifuchem.com

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Apejuwe:

Ruifu Kemikali Ipese Intermediates ibatan
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2- (3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Kemikali Properties:

Awọn itumọ ọrọ sisọ	BMS-477118;Onglyza;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxytricyclo [3.3.1.13,7] dec-1-yl) acetyl] -2-Azabicyclo [3.1.0] hexane -3-Carbonitrile
Nọmba CAS	361442-04-8
NỌMBA CAT	RF-PI1991
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular	C18H25N3O2
Òṣuwọn Molikula	315.41
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun Powder
Òórùn	Iwa
idanimọ	A: IR B: Aago Idaduro HPLC
Mimọ / Analysis Ọna	> 99.0% (HPLC)
Wipe Omi Solusan	Sihin, Alailowaya, Ko si Awọn ọrọ Idaduro
Sieve onínọmbà	100% Pass 80 Mesh
Ojuami Iyo	202.0 ~ 212.0 ℃
Pipadanu lori Gbigbe	<0.50%
Sulfated Ash	<0.20%
Yiyi pato	+ 174,0 ° ~ + 186,0 °
Aimọ Kanṣoṣo	<0.50%
Lapapọ Awọn Aimọ	<1.00%
Awọn irin Heavy	<10ppm
Arsenic (Bi)	<2.0ppm
Asiwaju (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Awọn ohun elo ti o ku	<100ppm
Ipakokoropaeku ti o ku	Odi
Microbiology
Apapọ Awo kika	<1000cfu/g
Iwukara & Mold	<100cfu/g
E. Kọli	Odi
S. Aureus	Odi
Salmonella	Odi
Igbesi aye selifu	Awọn oṣu 24 Lati Ọjọ iṣelọpọ ti o ba wa ni ipamọ daradara
Igbeyewo Standard	Standard Enterprise
Lilo	API;Iru 2 Àtọgbẹ mellitus

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

(BMS-477118) (CAS: 361442-04-8) jẹ agbara, yiyan, iyipada, ifigagbaga ati ẹnu ti nṣiṣe lọwọ dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.BMS-477118 ni peotential fun iwadii àtọgbẹ iru 2.BMS-477118jẹ oogun àtọgbẹ iru 2 ti o le mu ki oronro ṣiṣẹ lati ṣe agbejade insulin diẹ sii lẹhin ounjẹ.O ti de nipasẹ ifowosowopo ti AstraZeneca ati Bristol-Myers Squibb Company ati pe o jẹ ti inhibitor DPP-IV.BMS-477118ṣe ipa naa nipasẹ idilọwọ ibajẹ GLP-l.GLP-I jẹ awọn homonu ti a ṣẹda nipa ti ara ti o wa ninu ifun lẹhin ti o mu ounjẹ.O le ṣe ilana yomijade ti hisulini ati teramo lilo glukosi ninu awọn sẹẹli agbeegbe.Oogun ẹyọkan ti BMS-477118 le mu iṣakoso glukosi ẹjẹ pọ si ati oogun apapọ ti BMS-477118 pẹlu Metformin, Sulfonylurea ati Thiazolidinediones le mu ipa imularada pọ si.O yori si eewu kekere ti hypoglycemia ati awọn aati buburu rẹ jẹ iru si pilasibo, ti n ṣafihan ifarada ti o dara julọ.Ni Oṣu Keje Ọjọ 31, Ọdun 2009, BMS-477118 awọn tabulẹti (Onglyza), oogun tuntun ti iru àtọgbẹ 2, ṣe iwadii apapọ ati idagbasoke AstraZeneca ati Bristol-Myers Squibb ti fọwọsi nipasẹ US FDA.O le mu lẹẹkan lojoojumọ lati tọju iru àtọgbẹ 2 ni idapo pẹlu iṣakoso Ounjẹ ati adaṣe.