Lapatinib Ditosylate Monohydrate CAS 388082-78-8 Mimọ>99.0% (HPLC)
Orukọ Kemikali | Lapatinib Ditosylate Monohydrate |
Awọn itumọ ọrọ sisọ | N-[3-chloro-4-[(3-fluorophenyl) methoxy] phenyl] -6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
Nọmba CAS | 388082-78-8 |
Iṣura Ipo | O wa |
Fọọmu Molecular | C29H26ClFN4O4S·2(C7H8O3S)·H2O |
Òṣuwọn Molikula | 943.48 |
COA & MSDS | Wa |
Ipilẹṣẹ | Shanghai, China |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Bia Yellow to Yellow Crystalline Powder |
Mimọ / Analysis Ọna | ≥99.0% (HPLC) |
Ojuami Iyo | 240.0 ~ 242.0 ℃ |
Ọrinrin (KF) | 1.9 ~ 2.4% |
Aimọ Kanṣoṣo | ≤0.50% |
Lapapọ Awọn Aimọ | ≤1.00% |
Awọn irin Heavy (gẹgẹbi Pb) | ≤20ppm |
Igbeyewo Standard | Standard Enterprise |
Lilo | API;Fun itọju awọn alaisan ti o ni ọgbẹ igbaya |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8) jẹ iyọ ditosylate tiCAS 231277-92-2, sintetiki kan, quinazoline ti nṣiṣe lọwọ ẹnu pẹlu iṣẹ ṣiṣe antineoplastic ti o pọju.O tun ṣe idiwọ phosphorylation ti olugba idagba ifosiwewe epidermal (EGFR), ErbB2, ati Erk-1 ati-2 ati AKT kinases;o tun ṣe idiwọ awọn ipele amuaradagba cyclin D ninu awọn laini sẹẹli tumo eniyan ati awọn xenografts.EGFR ati ErbB2 ti ni ipa ninu idagbasoke ti ọpọlọpọ awọn oriṣi tumo.O ti ṣe ifilọlẹ fun itọju ti ilọsiwaju tabi metastatic HER2 (ErbB2) akàn igbaya rere ninu awọn obinrin ti o ti gba itọju ailera iṣaaju.Oogun naa jẹ awari ati idagbasoke nipasẹ GlaxoSmithKline.