TMC207 CAS 843663-66-1 Mimọ>99.5% (HPLC)
Awọn agbedemeji ti o jọmọ TMC207:
TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Orukọ Kemikali | TMC207 |
| Awọn itumọ ọrọ sisọ | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α- [2- (dimethylamino) ethyl] -2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1- (6-Bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2- (1-naphthyl) 2-butanol |
| Nọmba CAS | 843663-66-1 |
| NỌMBA CAT | RF2336 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C32H31BrN2O2 |
| Òṣuwọn Molikula | 555.516 |
| Ojuami Iyo | 104℃ |
| iwuwo | 1.322 ± 0,06 g / cm3 |
| Ni imọlara | Hygroscopic.Imọlẹ Imọlẹ, Afẹfẹ Ifamọ |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Pa-White Powder |
| Mimọ / Analysis Ọna | > 99.5% (HPLC) |
| Pipadanu lori Gbigbe | <0.50% |
| Aloku lori Iginisonu | <0.20% |
| Eyikeyi Olukuluku aimọ | <0.10% |
| Isomer | <0.10% |
| Lapapọ Awọn Aimọ | <0.50% |
| Awọn irin Heavy (gẹgẹbi Pb) | <20ppm |
| Arsenic (Bi) | <2.0ppm |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto |
| Proton NMR julọ.Oniranran | Ni ibamu si Eto |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
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DidaraIdaniloju?Idaniloju didara ti o gbẹkẹle, iṣakoso ti o muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
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Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ okun.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa.
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(CAS: 843663-66-1), (ti a mọ ni TMC207 ati R207910), ti a ta labẹ orukọ iṣowo Sirturo, jẹ aramada diarylquinoline antimycobacterial oogun ti o ni ipa lori iko nipa didi iṣẹ ṣiṣe ti M. tuberculosis ATP synthase proton pump.Iṣọkan ATP ti mycobacteria ṣe ipa antibacterial ati awọn ipakokoro.Ti a lo ni ile-iwosan lati ṣe itọju iko-ara ti ko ni oogun pupọ (MDR-PTB).TMC207 ni o ni kanna bactericidal aṣayan iṣẹ-ṣiṣe lodi si M. iko kókó igara ati sooro igara, ati ki o tun ni o dara sterilization ipa lori dormant kokoro arun.Ni Oṣu Kejila ọdun 2012, US FDA fọwọsi TMC207 gẹgẹ bi apakan ti itọju apapọ fun itọju ti iko-ara ti o ni oogun pupọ (MDRTB).TMC207 jẹ oogun akọkọ ti a fọwọsi fun MDR-TB ati pe o jẹ ifọwọsi akọkọ lati ọdọ kilasi tuntun ti awọn aṣoju antituberculosis ni ọdun 40 sẹhin.Nitori iwulo aini iṣoogun giga fun atọju MDR-TB, FDA funni ni ifọwọsi isare TMC207 ti o da lori awọn abajade Ipele II, pese awọn alaisan ni iwọle si oogun lakoko awọn iwadii ile-iwosan ni afikun.TMC207 jẹ diarylquinoline ti a ṣe awari lati ọna-giga, ilana ibojuwo gbogbo-cell pẹlu Mycobacterium smegmatis ti a lo bi aropo fun M. iko.TMC207 jẹ enantiomer kan ti kọlu iboju akọkọ.TMC207 ni o ni agbara ati aṣayan aṣayan iṣẹ-ṣiṣe lodi si mycobacteria, ati ki o jẹ lọwọ lodi si awọn oogun-kókó ati oògùn-sooro M. iko.Ilana iṣe ti TMC207 jẹ alailẹgbẹ laarin awọn oogun egboogi-TB ati pe o kan idinamọ ti mycobacterial ATP synthase;ko ṣiṣẹ lodi si ATP synthase eniyan.TMC207 ni iṣẹ-ṣiṣe ni vivo ni ọpọlọpọ awọn awoṣe preclinical ti ikolu TB, nikan ati ni apapo pẹlu awọn aṣoju egboogi-TB miiran, ati pe o ni iṣẹ-ṣiṣe kokoro-arun ni awọn awoṣe ikolu TB ti iṣeto.TMC207 jẹ iṣelọpọ ni awọn igbesẹ marun lati 3-Phenylpropionic Acid ati para-Bromoaniline.Ni atẹle idasile amide, itọju pẹlu POCl3 ati DMF labẹ awọn ipo Vilsmeier-Hack fun ọja 2-Chloroquinoline kan.Itọju pẹlu iṣuu soda methoxide, ti o tẹle pẹlu condensation pẹlu 3- (Dimethylamino) -1- (naphthalen-1-yl) propan-1-one, ati iyapa awọn isomers fun TMC207.
