Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ti (R) -5-Bromo-3- [1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] pyridin-2-Amine (CAS: 877399-00) -3) pẹlu didara to gaju, agbedemeji ti Crizotinib (CAS: 877399-52-5).Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | (R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Awọn itumọ ọrọ sisọ | Crizotinib Intermediate;Crizotinib Bromide Aimọ;5-Bromo-3- [(1R) -1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] -2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amin |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 877399-00-3 |
| Fọọmu Molecular | C13H10BrCl2FN2O |
| Òṣuwọn Molikula | 380,04 g / mol |
| Ojuami Iyo | 108.0 si 113.0 ℃ |
| iwuwo | 1.643 |
| COA & MSDS | Wa |
| Apeere | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | Agbedemeji ti Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Ina Yellow To Yellow Powder to Crystal | Ibamu |
| Ojuami Iyo | 108.0 si 113.0 ℃ | Ibamu |
| Mimọ (Agbegbe HPLC) | ≥98.0% | 99.1% |
| Excess Enantiomeric (EE) | ≥99.0% | 99.5% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| 1 H NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja yii ti ni idanwo & ni ibamu pẹlu awọn pato | |
| Igbesi aye selifu | Awọn ọdun 2 ti o ba fipamọ daradara | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy] pyridin-2-Amine (CAS: 877399-00-3) ni a lo bi agbedemeji ti Crizotinib (CAS: 877399-52-5).
Crizotinib jẹ pato oogun egboogi-akàn di alk (anaplastic lymphoma kinase) ati ros1 (c-ros oncogene 1) inhibitor, ti a fọwọsi fun itọju diẹ ninu awọn carcinoma ẹdọfóró sẹẹli ti kii-kekere (NSCLC) ni AMẸRIKA ati diẹ ninu awọn orilẹ-ede miiran, ati Ti n gba awọn iwadii lọpọlọpọ ti n ṣe idanwo aabo ati ipa rẹ ni anaplastic cell lymphoma nla, neuroblastoma, ati awọn èèmọ to lagbara to ti ni ilọsiwaju ninu awọn agbalagba ati awọn ọmọde.
Crizotinib jẹ oogun itọju ailera ti a fojusi fun akàn ẹdọfóró sẹẹli ti kii-kekere ti o dagbasoke nipasẹ Pfizer, AMẸRIKA, secorri jẹ aala ati oogun ti n ṣe epoch ni aaye ti itọju ìfọkànsí fun akàn ẹdọfóró.O ti fọwọsi fun tita ni Ilu Amẹrika ni Oṣu Kẹjọ ọdun 2011 ati pe a kọ sinu awọn ilana itọju akàn ẹdọfóró kariaye ni opin ọdun bi oogun laini akọkọ fun awọn alaisan ALK.Co-fọwọsi pẹlu Crizotinib jẹ ọna ayẹwo jiini akọkọ nipa lilo fluorescence ni situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, eyi ni ọna ti a lo lọwọlọwọ ni awọn idanwo ile-iwosan agbaye lati ṣawari awọn Jiini fusion EML4-ALK ni NSCLC.Idanwo yii yoo ṣe iranlọwọ idanimọ awọn alaisan ti o le ni anfani lati itọju Crizotinib.
Crizotinib jẹ oludena olugba olugba tyrosine kinase ti o yan ti a lo ninu itọju ailera ti awọn ọran ti a yan ti akàn ẹdọfóró ti kii-kekere sẹẹli ti ilọsiwaju.O jẹ oludena ifigagbaga ATP meji ti tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ati ALK (cellular IC50 = 20 nM), mejeeji ti awọn ibi-afẹde pataki fun chemotherapy akàn.Nigbati a ṣe idanwo Crizotinib fun yiyan si awọn kinases miiran o rii pe o ni henensiamu IC50's laarin 100-fold multiples ti c-MET fun 13 ti 120 kinases idanwo.Ninu awọn igbelewọn cellular, Crizotinib ni a rii lati ṣe idiwọ RON (recepteur d’origine nantais) kinase pẹlu window yiyan 10-fold lori c-MET.Lapapọ, aṣoju yii ṣe idiwọ idagbasoke sẹẹli tumo.XALKORI®(Crizotinib) jẹ oogun oogun ti a lo lati tọju awọn eniyan ti o ni akàn ẹdọfóró ti kii ṣe kekere (NSCLC) ti o ti tan si awọn ẹya ara miiran ti o fa nipasẹ abawọn ninu boya jiini ti a npe ni ALK (anaplastic lymphoma kinase) tabi Jiini ti a npe ni ROS1.A ko mọ boya XALKORI jẹ ailewu ati munadoko ninu awọn ọmọde.
