1-Boc-4- (4-Bromopyrazol-1-yl) piperidine CAS 877399-50-3 Purity ≥98.0% (HPLC)
Shanghai Ruifu Kemikali Co., Ltd jẹ olupese ti 1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) pẹlu didara to gaju, agbedemeji ti Crizotinib (CAS: 877399- 52-5).Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 1-Boc-4- (4-Bromopyrazol-1-yl) piperidine |
| Awọn itumọ ọrọ sisọ | Crizotinib-D;tert-Butyl 4- (4-Bromopyrazol-1-yl) piperidine-1-Carboxylate;4- (4-Bromopyrazol-1-yl) piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4- (4-Bromopyrazol-1-yl) piperidine;1- (4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4- (4-Bromo-1-Pyrazolyl) piperidine;4-Bromo-1- (N-Boc-Piperidin-4-yl) -1H-Pyrazole;tert-butyl 4- (4-Bromo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;1- (4-Boc-1-Piperidinyl) -4-Bromopyrazole;Crizotinib aimọ 4 |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 877399-50-3 |
| Fọọmu Molecular | C13H20BrN3O2 |
| Òṣuwọn Molikula | 330,23 g / mol |
| Ojuami Iyo | 77.0 si 81.0 ℃ |
| iwuwo | 1.43 |
| Solubility | Tiotuka ni kẹmika |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | Agbedemeji ti Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | White Ri to | White Ri to |
| Ojuami Iyo | 77.0 si 81.0 ℃ | Ibamu |
| Omi nipa Karl Fischer | <0.50% | 0.11% |
| Mimọ / Analysis Ọna | ≥98.0% (HPLC) | 99.3% |
| 1H NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ibi | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Awọn aami ewu Xn - ipalara
Awọn koodu Ewu 22 - Ipalara ti o ba gbemi
1-Boc-4- (4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) ni a lo gẹgẹbi agbedemeji ti Crizotinib (CAS: 877399-52-5).Crizotinib (orukọ iṣowo Xalkori,) jẹ oogun egboogi-akàn ti n ṣiṣẹ bi ALK (anaplastic lymphoma kinase) ati inhibitor ROS1 (c-ros oncogene 1), ti a fọwọsi fun itọju diẹ ninu awọn carcinoma ẹdọfóró sẹẹli ti kii ṣe kekere (NSCLC) ni AMẸRIKA ati diẹ ninu awọn orilẹ-ede miiran, ati awọn idanwo ile-iwosan ti n ṣe idanwo aabo ati imunadoko rẹ inaplastic ti o tobi cell lymphoma, neuroblastoma, ati awọn èèmọ to ti ni ilọsiwaju miiran ni awọn agbalagba ati awọn ọmọde.
Ni Oṣu Kẹjọ ọdun 2011, Amẹrika FDA fọwọsi Crizotinib (PF-02341066) fun itọju ti lymphoma kinase anaplastic (ALK) ṣe atunṣe akàn ẹdọfóró ti kii-kekere-kekere (NSCLC).Crizotinib jẹ oludaniloju ifigagbaga ATP meji ti tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ati ALK (cellular IC50 = 20 nM), mejeeji ti awọn ibi-afẹde pataki fun chemotherapy akàn.Nigbati a ṣe idanwo Crizotinib fun yiyan si awọn kinases miiran o rii pe o ni henensiamu IC50's laarin 100-fold multiples ti c-MET fun 13 ti 120 kinases idanwo.Ninu awọn igbelewọn cellular, Crizotinib ni a rii lati ṣe idiwọ RON (recepteur d’origine nantais) kinase pẹlu window yiyan 10-fold lori c-MET.
