1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole CAS 877399-73-0 Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ ti 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) pẹlu didara to gaju, agbedemeji ti Crizotinib (CAS: 877399-52) -5).Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | 1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Awọn itumọ ọrọ sisọ | 1-Boc-4- (4-Iodo-1H-Pyrazol-1-yl) piperidine;tert-Butyl 4- (4-Iodo-1H-Pyrazol-1-yl) piperidine-1-Carboxylate;tert-Butyl 4- (4-Iodopyrazolyl) piperidinecarboxylate;Crizotinib aimọ 16 |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 877399-73-0 |
| Fọọmu Molecular | C13H20IN3O2 |
| Òṣuwọn Molikula | 377,22 g / mol |
| Ojuami Iyo | 97℃ |
| iwuwo | 1,60 ± 0,10 g / cm3 |
| Ni imọlara | Imọlẹ Imọlẹ |
| Ibi ipamọ otutu. | 2 ~ 8 ℃, Daabobo Lati Imọlẹ |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Ẹka | Agbedemeji ti Crizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Funfun to Light Yellow ri to | White Ri to |
| Mimọ / Analysis Ọna | ≥99.0% (HPLC) | 99.58% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| 1 H NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| ESI+ | Ni ibamu | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
1- (1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) pẹlu didara to gaju, agbedemeji ti Crizotinib (CAS: 877399-52-5).Crizotinib jẹ oogun itọju ailera ti a fojusi fun akàn ẹdọfóró sẹẹli ti kii-kekere ti o dagbasoke nipasẹ Pfizer, AMẸRIKA, secorri jẹ aala ati oogun ti n ṣe epoch ni aaye ti itọju ìfọkànsí fun akàn ẹdọfóró.O ti fọwọsi fun tita ni Ilu Amẹrika ni Oṣu Kẹjọ ọdun 2011 ati pe a kọ sinu awọn ilana itọju akàn ẹdọfóró kariaye ni opin ọdun bi oogun laini akọkọ fun awọn alaisan ALK.Co-fọwọsi pẹlu Crizotinib jẹ ọna ayẹwo jiini akọkọ nipa lilo fluorescence ni situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, eyi ni ọna ti a lo lọwọlọwọ ni awọn idanwo ile-iwosan agbaye lati ṣawari awọn Jiini fusion EML4-ALK ni NSCLC.Idanwo yii yoo ṣe iranlọwọ idanimọ awọn alaisan ti o le ni anfani lati itọju Crizotinib.lori 25, yi ni akọkọ oògùn lati ṣee lo ninu awọn itọju ti awọn alaisan pẹlu tibile to ti ni ilọsiwaju tabi metastatic ti kii-kekere cell ẹdọfóró akàn (NSCLC) ti o jẹ anaplastic lymphoma kinase (ALK) -rere bi ṣiṣe nipasẹ ohun SFDA-fọwọsi igbeyewo.
Crizotinib (PF-02341066) Crizotinib jẹ c-Met ti o lagbara ati inhibitor ALK, awọn iye IC50 ninu ayẹwo sẹẹli jẹ 11 nM ati 24 nM, lẹsẹsẹ.O tun jẹ inhibitor ti o lagbara ti ROS1 pẹlu iye Ki ti o kere ju 0.025 nM.Crizotinib le fa autophagy ni ọpọlọpọ awọn laini sẹẹli akàn ẹdọfóró nipasẹ didi ọna STAT3.
