CAS 945667-22-1 Mimo>99.0% (HPLC) API Aworan Ifihan

CAS 945667-22-1 Mimọ>99.0% (HPLC) API

Apejuwe kukuru:

CAS: 945667-22-1

Mimọ:> 99.0% (HPLC)

Irisi: White Powder

API, Didara Giga, Ṣiṣejade Iṣowo

E-Mail: alvin@ruifuchem.com

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ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates ibatan
CAS 361442-04-8
CAS 945667-22-1
(R) -1-Boc-3-Aminoperidine CAS 188111-79-7
(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2- (3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Kemikali Properties:

Awọn itumọ ọrọ sisọ	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ] hexane-3-Carbonitrile Hydrate
Nọmba CAS	945667-22-1
NỌMBA CAT	RF-PI1992
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular	C18H25N3O2·H2O
Òṣuwọn Molikula	333.43
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun Powder
idanimọ	A: IR B: Aago Idaduro HPLC
Mimọ / Analysis Ọna	> 99.0% (HPLC, Lori ipilẹ gbigbe)
Akoonu Omi (KF)	5.3% ~ 7.3%
Aloku lori Iginisonu	<0.20%
Aimọ Kanṣoṣo	<0.50%
Lapapọ Awọn Aimọ	<1.00%
Awọn irin Heavy	<10ppm
Arsenic (Bi)	<2ppm
Microbiology
Apapọ Awo kika	<1000cfu/g
Iwukara & Mold	<100cfu/g
E. Kọli	Odi
S. Aureus	Odi
Salmonella	Odi
Igbesi aye selifu	24 osu
Igbeyewo Standard	Standard Enterprise
Lilo	API;Ti a lo fun Itọju Iru II Àtọgbẹ

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

API (CAS: 945667-22-1) jẹ yiyan ati iparọ dipeptidyl peptidase-4 (DPP4) inhibitor ti o le ṣee lo lati ṣe agbekalẹ itọju fun àtọgbẹ 2 iru.O jẹ oludaniloju DPP4 ti o yan ati iyipada pẹlu IC50 ti 26 nM ati Ki ti 1.3 nM.IC50 iye: 26 nM.Ibi-afẹde: DPP4 in vitro: O ni idinamọ nigbagbogbo Ki ti 1.3 nM fun idinamọ DPP4, eyiti o jẹ 10-agbo diẹ sii ju Sitagliptin (awọn inhibitors DPP4 meji miiran) pẹlu Ki ti 13 ati 18 nM.Ni afikun, O ṣe afihan iyasọtọ nla fun DPP4 ju fun boya DPP8 tabi awọn enzymu DPP9 (400- ati 75-fold, lẹsẹsẹ).Metablite ti nṣiṣe lọwọ rẹ jẹ ilọpo meji kere si agbara ju obi lọ.Mejeeji (CAS: 945667-22-1) ati metabolite rẹ jẹ yiyan pupọ (> 4000-fold) fun idena ti DPP4 ni akawe pẹlu ọpọlọpọ awọn proteases miiran.(CAS: 945667-22-1) dinku ibajẹ ti homonu incretin glucagon-like peptide-1, nitorinaa mu awọn iṣe rẹ pọ si, ati pe o ni nkan ṣe pẹlu ilọsiwaju iṣẹ β-cell ati idinku ti secretion glucagon.in vivo: O munadoko pupọ. ni jijade awọn imudara igbẹkẹle iwọn lilo ti o samisi ni imukuro glukosi ni iwọn iwọn lilo 0.13-1.3 mg/kg ninu awọn eku ob/ob ni ibatan si awọn iṣakoso.