CAS 945667-22-1 Mimọ>99.0% (HPLC) API
Ruifu Kemikali Ipese Intermediates ibatan
CAS 361442-04-8
CAS 945667-22-1
(R) -1-Boc-3-Aminoperidine CAS 188111-79-7
(R)-(-)-3-Aminopperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2- (3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7
Awọn itumọ ọrọ sisọ | BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2- [(2S) -2-Amino-2- (3-Hydroxy-1-Adamantyl) acetyl] -2-Azabicyclo [3.1.0] hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ] hexane-3-Carbonitrile Hydrate |
Nọmba CAS | 945667-22-1 |
NỌMBA CAT | RF-PI1992 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C18H25N3O2·H2O |
Òṣuwọn Molikula | 333.43 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun Powder |
idanimọ | A: IR B: Aago Idaduro HPLC |
Mimọ / Analysis Ọna | > 99.0% (HPLC, Lori ipilẹ gbigbe) |
Akoonu Omi (KF) | 5.3% ~ 7.3% |
Aloku lori Iginisonu | <0.20% |
Aimọ Kanṣoṣo | <0.50% |
Lapapọ Awọn Aimọ | <1.00% |
Awọn irin Heavy | <10ppm |
Arsenic (Bi) | <2ppm |
Microbiology | |
Apapọ Awo kika | <1000cfu/g |
Iwukara & Mold | <100cfu/g |
E. Kọli | Odi |
S. Aureus | Odi |
Salmonella | Odi |
Igbesi aye selifu | 24 osu |
Igbeyewo Standard | Standard Enterprise |
Lilo | API;Ti a lo fun Itọju Iru II Àtọgbẹ |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
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API (CAS: 945667-22-1) jẹ yiyan ati iparọ dipeptidyl peptidase-4 (DPP4) inhibitor ti o le ṣee lo lati ṣe agbekalẹ itọju fun àtọgbẹ 2 iru.O jẹ oludaniloju DPP4 ti o yan ati iyipada pẹlu IC50 ti 26 nM ati Ki ti 1.3 nM.IC50 iye: 26 nM.Ibi-afẹde: DPP4 in vitro: O ni idinamọ nigbagbogbo Ki ti 1.3 nM fun idinamọ DPP4, eyiti o jẹ 10-agbo diẹ sii ju Sitagliptin (awọn inhibitors DPP4 meji miiran) pẹlu Ki ti 13 ati 18 nM.Ni afikun, O ṣe afihan iyasọtọ nla fun DPP4 ju fun boya DPP8 tabi awọn enzymu DPP9 (400- ati 75-fold, lẹsẹsẹ).Metablite ti nṣiṣe lọwọ rẹ jẹ ilọpo meji kere si agbara ju obi lọ.Mejeeji (CAS: 945667-22-1) ati metabolite rẹ jẹ yiyan pupọ (> 4000-fold) fun idena ti DPP4 ni akawe pẹlu ọpọlọpọ awọn proteases miiran.(CAS: 945667-22-1) dinku ibajẹ ti homonu incretin glucagon-like peptide-1, nitorinaa mu awọn iṣe rẹ pọ si, ati pe o ni nkan ṣe pẹlu ilọsiwaju iṣẹ β-cell ati idinku ti secretion glucagon.in vivo: O munadoko pupọ. ni jijade awọn imudara igbẹkẹle iwọn lilo ti o samisi ni imukuro glukosi ni iwọn iwọn lilo 0.13-1.3 mg/kg ninu awọn eku ob/ob ni ibatan si awọn iṣakoso.
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CAS 361442-04-8 Mimọ>99.0% (HPLC) API
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CAS 945667-22-1 Mimọ>99.0% (HPLC) API
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