Celecoxib CAS 169590-42-5 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Celecoxib (CAS: 169590-42-5) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Celecoxib,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Celecoxib |
| Awọn itumọ ọrọ sisọ | Celebrex;Ayẹyẹ;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4- [5- (4-Methylphenyl) -3- (Trifluoromethyl) -1H-Pyrazol-1-yl] benzenesulfonamide;5- (4-Methylphenyl) -1- (4-Sulfamoylphenyl) -3- (Trifluoromethyl) pyrazole |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 169590-42-5 |
| Fọọmu Molecular | C17H14F3N3O2S |
| Òṣuwọn Molikula | 381,37 g / mol |
| Ojuami Iyo | 160.0 si 165.0 ℃ |
| iwuwo | 1,43 ± 0,10 g / cm3 |
| Omi Solubility | Ailopin ninu Omi |
| Solubility | Tiotuka pupọ ni kẹmika;Soluble ni Ethanol |
| COA & MSDS | Wa |
| Apeere | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Funfun tabi Fere White Crystalline Powder | Ibamu |
| Ayẹwo | 98.0 ~ 102.0% | 99.8% |
| Ojuami Iyo | 160.0 si 165.0 ℃ | 162.2 ℃ |
| Omi nipa Karl Fischer | <0.50% | 0.11% |
| Aloku lori Iginisonu | <0.20% | 0.05% |
| Awọn Irin Eru (Pb) | ≤20ppm | <10ppm |
| Agbo ti o jọmọ Celecoxib A | <0.40% | <0.20% |
| Celecoxib Jẹmọ Agbo B | <0.10% | <0.10% |
| Olukuluku aimọ ti ko ni pato | <0.10% | <0.10% |
| Lapapọ awọn idoti | <0.50% | 0.20% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| 1H NMR julọ.Oniranran | Ni ibamu pẹlu Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Celecoxib
C17H14F3N3O2S 381.4
4- [5- (4-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide;
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide [169590-42-5]
ITUMO
Celecoxib ni NLT 98.0% ati NMT 102.0% ti C17H14F3N3O2S, iṣiro lori ipilẹ anhydrous
Ìdámọ̀
A. INFRED ABSORPTION <197>: [Awọn ọna AKIYESI <197A>, <197K>, tabi <197M> labẹ gbigba Infurarẹẹdi le ṣee lo.]
[AKIYESI-Ti o ba jẹ pe iwoye ti o gba ni afihan awọn iyatọ, tu nkan ti o yẹ lati ṣe ayẹwo ati Itọkasi Itọkasi lọtọ ni ọti isopropyl, yọ kuro si gbigbẹ, ki o ṣe igbasilẹ iwoye tuntun.]
• B. Awọn akoko idaduro ti awọn pataki tente oke ti awọn Ayẹwo ojutu ni ibamu si awọn ti Standard ojutu, bi gba ninu awọn Assay.
ASAY
• Ilana
Idaduro: 2.7 g/L ti fosifeti potasiomu monobasic ti a ṣatunṣe pẹlu phosphoric acid si pH ti 3.0 ± 0.2
Ipele alagbeka: kẹmika, acetonitrile, ati Buffer (3:1:6)
Diluent: kẹmika ati omi (3: 1)
Ojutu ibaamu eto: 0.5 mg/mL ti USP
Celecoxib RS ati 2.4 µg/mL kọọkan ti USP Celecoxib Jẹmọ Compound A RS ati USP Celecoxib Jẹmọ Compound B RS ni Diluent
Ojutu boṣewa: 0.5 mg/mL ti USP Celecoxib RS ni Diluent
Ojutu ayẹwo: 0.5 mg/mL ti Celecoxib ni Diluent
Eto Chromatographic
(Wo Chromatography <621>, Ibamu Eto.)
Ipo: LC
Oluwadi: UV 215 nm
Ọwọn: 4.6-mm × 25-cm;5-µm iṣakojọpọ L11
Iwọn otutu: 60°
Oṣuwọn sisan: 1.5 milimita / min
Iwọn abẹrẹ: 25 µL
Akoko ṣiṣe: Nipa awọn akoko 1.5 celecoxib tente oke elution
Ibamu eto
Awọn apẹẹrẹ: Ojutu ibamu eto ati ojutu Standard
Awọn ibeere ibamu
Ipinnu: NLT 1.8 laarin idapọ ti o ni ibatan celecoxib A ati Celecoxib ati NLT 1.8 laarin Celecoxib ati Celecoxib ti o ni ibatan agbo-ara B, ojutu ibamu eto
Ojulumo boṣewa iyapa: NMT 0.73%, Standard ojutu
Onínọmbà
Awọn apẹẹrẹ: Ojutu boṣewa ati ojutu Ayẹwo
Ṣe iṣiro ipin ogorun C17H14F3N3O2S ni apakan ti Celecoxib ti o mu:
Esi = (rU/rS) × (CS/CU) × 100
rU = idahun ti o ga julọ lati inu ojutu Ayẹwo
rS = idahun ti o ga julọ lati ojutu Standard
CS = ifọkansi ti ojutu Standard (mg/mL)
CU = ifọkansi ti ojutu Ayẹwo (mg/mL)
Awọn ibeere gbigba: 98.0% ~ 102.0% lori ipilẹ anhydrous
ALÁÌṢẸ́
Awọn Egbin Aiṣedeede
• Awọn irin eru: NMT 20 ppm
Diluent: Acetone ati omi (17: 3)
Ojutu boṣewa: Dilute 1.0 milimita ti Solusan Lead Standard, ti a pese silẹ bi a ti ṣe itọsọna labẹ Awọn irin Heavy <231>, Awọn Reagents Pataki, pẹlu Diluent si 20 milimita.
Ojutu ayẹwo: tu 0.50 g Celecoxib ni 20mL ti Diluent.
Ojutu òfo: 20 milimita ti Diluent
Onínọmbà
Awọn apẹẹrẹ: Ojutu boṣewa, Ojutu òfo, ati ojutu Ayẹwo
Si ojutu kọọkan, ṣafikun 2 mL ti pH 3.5 Acetate Buffer ti a pese silẹ gẹgẹbi a ti ṣe itọsọna labẹ Awọn irin Heavy <231>, Ọna I. Mix, ati ṣafikun si ojutu kọọkan 1.2 mL ti thioacetamide-glycerin mimọ TS.Illa lẹsẹkẹsẹ, ki o jẹ ki o duro fun iṣẹju 2.Ṣe awọn ojutu nipasẹ àlẹmọ ti iwọn pore 0.45-µm.Ṣe afiwe awọn aaye lori awọn asẹ ti a gba lati ọkọọkan awọn ojutu.
Awọn ibeere gbigba: Awọ-awọ-awọ-awọ-awọ-awọ-awọ ti aaye ti o waye lati inu ojutu Ayẹwo ko ni iwọn diẹ sii ju ti aaye ti o waye lati ojutu Standard.Idanwo naa ko wulo ti ojutu Standard ko ba ṣe afihan awọ brownish-dudu ni akawe si ojutu Ofo.
• IKU LORI IGNITION <281>: NMT 0.2%, ni lilo crucible platinum kan
Organic impurities
• Ilana
Ifipamọ, Alagbeka Alagbeka, Diluent, Ojutu ibamu eto, Ojutu Ayẹwo, ati eto Chromatographic: Tẹsiwaju bi a ti ṣe itọsọna ni Assay.
Ojutu boṣewa: 0.5 µg/ml ti USP Celecoxib RS ni Diluent
Ibamu eto
Awọn apẹẹrẹ: Ojutu ibamu eto ati ojutu Standard
Awọn ibeere ibamu
Ipinnu: NLT 1.8 laarin idapọ ti o ni ibatan Celecoxib A ati Celecoxib ati NLT 1.8 laarin Celecoxib ati Celecoxib ti o ni ibatan agbo-ara B, ojutu ibamu eto
Ipin ifihan agbara-si-ariwo: NLT 20, Ojutu Standard
Onínọmbà
Awọn apẹẹrẹ: Ojutu boṣewa ati ojutu Ayẹwo
Ṣe iṣiro ipin ogorun aimọ kọọkan ni apakan ti Celecoxib ti o mu:
Esi = (rU/rS) × (CS/CU) × 100
rU = idahun ti o ga julọ fun aimọ kọọkan ninu ojutu Ayẹwo
rS = idahun ti o ga julọ ti celecoxib ni ojutu Standard
CS = ifọkansi ti celecoxib ninu ojutu Standard (mg/mL)
CU = ifọkansi ti Celecoxib ninu ojutu Ayẹwo (mg/mL)
Awọn ilana gbigba
Awọn aimọ ẹni kọọkan: Wo Tabili 1.
[AKIYESI-Kiyesi eyikeyi tente aimọ ti o kere ju 0.05%.]
Tabili 1
| Oruko | Ojulumo Idaduro Time | Ilana gbigba NMT (%) |
| Celecoxib ti o ni ibatan agbo Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Celecoxib ti o ni ibatan agbo Bb | 1.1 | 0.10 |
| Olukuluku aimọ ti ko ni pato | - | 0.10 |
| Lapapọ awọn idoti | - | 0.5 |
a 4- [5- (3-Methylphenyl)) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
b 4- [3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
Awọn idanwo pataki
• Ipinnu OMI, Ọna I <921>: NMT 0.5%, lilo apẹẹrẹ 400-mg
Awọn ibeere afikun
• Iṣakojọpọ ati Ipamọ: Fipamọ sinu awọn apoti ti o nipọn, aabo lati ina ati ọrinrin.Fipamọ ni iwọn otutu yara
• USP awọn Ilana itọkasi <11>
USP Celecoxib RS
p-[5-p-Tolyl-3- (trifluoromethyl) pyrazol-1-yl] benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Jẹmọ Agbo A RS
4- [5- (3-Methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Jẹmọ Agbo B RS
4- [3- (4-Methylphenyl) -5- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide.
C17H14F3N3O2S 381.4
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
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DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
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| Awọn aami ewu | Xn - ipalara |
| Awọn koodu ewu | R20/21/22 - Ipalara nipasẹ ifasimu, ni olubasọrọ pẹlu awọ ara ati ti o ba gbe. |
| R52 - ipalara si awọn oganisimu omi | |
| R61 - Le fa ipalara si awọn unborn ọmọ | |
| R60 - Le impair irọyin | |
| Apejuwe Abo | S22 - Maṣe simi eruku. |
| S24/25 - Yago fun olubasọrọ pẹlu ara ati oju. | |
| S28 - Lẹhin olubasọrọ pẹlu awọ ara, wẹ lẹsẹkẹsẹ pẹlu ọpọlọpọ ọṣẹ-suds. | |
| S37/39 - Wọ awọn ibọwọ ti o dara ati aabo oju / oju | |
| UN ID | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | DB2944937 |
| HS koodu | 2935900090 |
| Kíláàsì ewu | IKANU |
Celecoxib ati Rofecoxib jẹ awọn inhibitors COX-2 meji ti a lo lọwọlọwọ.Ni aṣeyọri ni idagbasoke nipasẹ GD Searle & Pfizer Co. (US,) ti a tu silẹ ni ọdun 1999, orukọ iṣowo: Celebrex.Celecoxib jẹ aiṣe-sitẹriọdu, aṣoju egboogi-iredodo pẹlu analgesic pataki ati awọn ipa-iredodo, nfa iṣẹlẹ ti o kere julọ ti awọn ọgbẹ inu ikun ati inu ati awọn ilolu miiran.Ti a lo ni ile-iwosan lati tọju osteoarthritis nla ati onibaje ati arthritis rheumatoid, pẹlu ipa analgesic egboogi-iredodo, yiyọ awọn ami ati awọn aami aiṣan ti osteoarthritis ati arthritis rheumatoid.
Celecoxib (CAS: 169590-42-5), Fun iderun ati iṣakoso ti osteoarthritis (OA), arthritis rheumatoid (RA), arthritis rheumatoid ti ọmọde (JRA), spondylitis ankylosing, irora nla, dysmenorrhea akọkọ ati afikun ẹnu si itọju deede fun awọn alaisan. pẹlu polyposis adenomatous idile.
Celecoxib (CAS: 169590-42-5) ni egboogi-iredodo ati ipa analgesic ti awọn NSAIDs.Nitori eto kemikali rẹ, o le ni idapo pelu COX-2, yiyan idilọwọ COX-2.Ẹgbẹ phenyl rẹ sopọ pẹlu ikanni hydrophobic ti COX-2, ati hydrophilic sulfonamide rẹ ṣe apẹrẹ ẹwọn hydrogen kan pẹlu 513 arginine ati 90 histidine ninu COX-2 “apo ẹgbẹ.”O tun wa ni isunmọ pẹlu arginine ni ipo COX-2120 ati pe o ṣe ipa ninu idinamọ COX-2 lati yiyipada arachidonic acid si awọn prostaglandins eyiti o jẹ ipalara si ara eniyan. -2, Celecoxib ko le wọ inu moleku COX-1, tabi ṣe idiwọ iyipada rẹ ti arachidonic acid sinu prostaglandins. Bayi, o ni egboogi-iredodo ati awọn ipa analgesic ti o dara, ṣe aabo fun mucosa inu, ṣe idaabobo sisan ẹjẹ kidirin, ṣe atunṣe iṣakojọpọ platelet, ati ipinnu Awọn iṣoro híhún inu ti awọn NSAID ti a lo nigbagbogbo.
Celecoxib (CAS: 169590-42-5) jẹ itọkasi fun itọju osteoarthritis ati arthritis rheumatoid.Lilo rẹ jẹ contraindicated ni awọn ẹni-kọọkan pẹlu ifamọ si sulfonamides tabi awọn NSAID miiran.O yẹ ki o lo pẹlu iṣọra ni awọn eniyan ti o ni arun ẹdọ.Awọn ibaraẹnisọrọ waye pẹlu awọn oogun miiran ti o fa CYP2C9 (fun apẹẹrẹ rifampin rifampin) tabi ti njijadu fun iṣelọpọ agbara nipasẹ enzymu yii (fun apẹẹrẹ fluconazole, leflunomide).Awọn aati ikolu ti o wọpọ julọ si celecoxib jẹ ìwọnba si awọn ipa GI iwọntunwọnsi bii dyspepsia, gbuuru, ati irora inu.GI to ṣe pataki ati awọn ipa kidirin ti ṣẹlẹ ṣọwọn.
