D-(+) -Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory Didara Didara
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ti D- (+) -Cycloserine (CAS: 68-41-7) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, kekere ati awọn iwọn olopobobo ti o wa.Ra D-(+) -Cycloserine,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | D- (+) -Cycloserine |
| Awọn itumọ ọrọ sisọ | D-Cycloserine;(+) - Cycloserine;(R) (+) - Cycloserine;(R)-(+) -4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Iṣura Ipo | O wa |
| Nọmba CAS | 68-41-7 |
| Ilana molikula | C3H6N2O2 |
| Òṣuwọn Molikula | 102,09 g / mol |
| Ojuami Iyo | 137 ℃ |
| Ni imọlara | Afẹfẹ Sensitive, Ooru kókó |
| Solubility | Tiotuka ninu Omi.Tiotuka die-die ni kẹmika ati Propylene Glycol.Ailopin ninu Chloroform ati Eteri. |
| Ibi ipamọ otutu. | Itura & Ibi Gbẹ (2 ~ 8℃) |
| COA & MSDS | Wa |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Awọn abajade |
| Ifarahan | Funfun tabi Bia Yellowish Crystalline Powder | Ibamu |
| Yiyi pato [α] 20/D | +108.0° si +114.0° (C=5, 2N NaOH) | + 111,9 ° |
| Idanimọ | Awọ buluu Dididiẹ ni idagbasoke | Awọ Buluu |
| Condensation Products | ≤0.80% (ni 286nm) | 0.08% |
| Pipadanu lori Gbigbe | <1.00% | 0.38% |
| Aloku lori Iginisonu | <0.50% | 0.10% |
| Awọn Irin Eru (Pb) | ≤10ppm | <10ppm |
| Idoti Alailowaya | ||
| - kẹmika | ≤500ppm | <500ppm |
| - acetone | ≤500ppm | <500ppm |
| Agbeyewo (Awọn oogun aporo-oogun-iṣayẹwo microbial) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 si 6.5 | 5.98 |
| FTIR | Ni ibamu | Ni ibamu |
| IR julọ.Oniranran | Ni ibamu | Ni ibamu |
| NMR julọ.Oniranran | Ni ibamu | Ni ibamu |
| Ipari | Ọja yii nipasẹ awọn ibamu ayewo pẹlu boṣewa USP-35 | |
Cycloserine [68-41-7].
Cycloserine ni agbara ti ko din ju 900µg ti C3H6N2O2 fun miligiramu.
Iṣakojọpọ ati ibi ipamọ-Fipamọ sinu awọn apoti ti o muna.
Awọn ajohunše Itọkasi USP <11>-
USP Cycloserine RS
Idanimọ-tu nipa miligiramu 1 ninu 10 milimita ti 0.1 N sodium hydroxide.Si 1 milimita ti ojutu Abajade ṣafikun 3 milimita ti 1 N acetic acid ati 1 milimita ti adalu, pese sile fun wakati kan ṣaaju lilo, ti awọn ẹya dogba ti ojutu nitroprusside sodium (1 ni 25) ati 4 N sodium hydroxide: awọ buluu diėdiẹ ndagba.
Awọn ọja ifunmọ-Iwọn gbigba rẹ (wo Spectrophotometry ati Itupa Imọlẹ <851>) ni 285 nm, ti a pinnu ni 0.1 N iṣuu soda hydroxide ojutu ti o ni 0.40 mg fun milimita ko ju 0.80 lọ.
Yiyi pato <781S>: laarin 108° ati 114°.Ojutu idanwo: 50 mg fun milimita, ni 2 N sodium hydroxide.
Crystallinity <695>: pàdé awọn ibeere
pH <791>: laarin 5.5 ati 6.5, ni ojutu kan (1 ni 10).
Pipadanu lori gbigbe <731>-Gbẹ nipa 100 miligiramu ninu igo capillar y-stoppered ni igbale ni 60℃ fun wakati 3: ko padanu diẹ sii ju 1.0% ti iwuwo rẹ.
Ajẹkù lori iginisonu <281>: ko ju 0.5% lọ, iyoku gbigbo jẹ tutu pẹlu 2 milimita nitric acid ati 5 silė ti sulfuric acid.
Ayẹwo-
pH 6.8 Phosphate buffer-Murasilẹ bi a ti ṣe itọsọna ni Awọn Solusan Buffer labẹ Awọn Solusan ni apakan Reagents, Awọn Atọka, ati Awọn Solusan.
Mobile alakoso-tu 0.5 g ti iṣuu soda 1-decanesulfonate ni 800 milimita ti omi, fi 50 milimita ti acetonitrile ati 5 milimita ti glacial acetic acid, ati ki o dapọ.Ṣatunṣe pẹlu 1 N sodium hydroxide si pH ti 4.4.Àlẹmọ, ati degas.Ṣe awọn atunṣe ti o ba jẹ dandan y (wo Ibaramu Eto labẹ Chromatography <621>).
Igbaradi boṣewa-ni pipo tu ohun deede iwọn opoiye ti USP Cycloserine RS ni pH 6.8 Phosphate ifipamọ lati gba ojutu kan nini ifọkansi ti a mọ ti nipa 0.4 mg fun milimita.
Assay igbaradi-Gbigbe lọ si iwọn 20 miligiramu ti Cycloserine, ni iwọn deede, si ọpọn iwọn didun 50-mL, tu sinu ati dilute pẹlu pH 6.8 Phosphate buffer si iwọn didun, ati dapọ.
Eto Chromatographic (wo Chromatography <621>)) -Kromatograph olomi ti ni ipese pẹlu aṣawari 219-nm ati iwe 4.6-mm × 25-cm ti o ni iṣakojọpọ 5-µm L1.Iwọn sisan jẹ nipa 1 milimita fun iṣẹju kan.Iwọn otutu ọwọn ti wa ni itọju ni iwọn 30 °.Chromatograph the Standard igbaradi, ati ki o gbasilẹ awọn idahun ti o ga julọ bi a ti ṣe itọsọna fun Ilana: ifosiwewe iru ko ju 1.8 lọ;ati iyapa boṣewa ojulumo fun awọn abẹrẹ ẹda ko ju 2.0%.
Ilana-Lọtọ ara awọn iwọn didun dogba (nipa 10 µL) ti igbaradi Standard ati igbaradi Assay sinu chromatograph, ṣe igbasilẹ awọn chromatogram, ati wiwọn awọn idahun ti o ga julọ fun cycloserine.Ṣe iṣiro iye, ni µg, ti C3H6N2O2 ninu miligiramu kọọkan ti Cycloserine ti a mu nipasẹ agbekalẹ:
50,000(C/W)(rU/rS)
ninu eyiti C jẹ ifọkansi, ni mg fun milimita, ti USP Cycloserine RS ni igbaradi Standard;W jẹ opoiye, ni mg, ti Cycloserine ti a mu lati ṣeto igbaradi Assay;ati rU ati rS jẹ awọn idahun ti o ga julọ fun cycloserine ti a gba lati igbaradi Assay ati igbaradi Standard, lẹsẹsẹ.
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti edidi ni itura ati ki o gbẹ (2 ~ 8℃) ile itaja kuro lati awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
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S38 - Ni ọran ti aipe afẹfẹ, wọ awọn ohun elo atẹgun ti o dara.
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D- (+) - Cycloserine (CAS: 68-41-7) ni iseda hygroscopic ti o lagbara, o jẹ tiotuka ninu omi, tiotuka diẹ ninu awọn ọti-lile kekere, acetone ati dioxane, ati pe ko ṣee ṣe ni chloroform ati ether epo.O jẹ iduroṣinṣin diẹ ninu ojutu ipilẹ ati decomposes ni iyara ni ekikan tabi awọn ojutu didoju.Gẹgẹbi oogun aporo ti o gbooro, cycloserine jẹ inhibitive lodi si pupọ julọ Gram-positive ati Gram-negative kokoro arun, rickettsia ati diẹ ninu awọn protozoa, pẹlu ayafi ti Mycobacterium iko., O tun munadoko lori diẹ ninu awọn igara iko-ara Mycobacterium pẹlu ifarada si streptomycin vinactane para-aminosalicylic acid, isoniazid ati pyrazinamide.Cycloserine jẹ mimuuṣiṣẹpọ diẹ pẹlu isoniazid ni idinamọ ti Mycobacterium tuberculosis H37RV, ṣugbọn ko ṣiṣẹpọ tabi atako lodi si streptomycin.Ọja naa jẹ oluranlowo bacteriostatic, ati nitorinaa kii yoo ṣe ipa kokoro-arun paapaa nigba ti o pọ si iwọn lilo tabi gigun akoko iṣe pẹlu awọn kokoro arun.
Ilana ti D-cycloserine's antibacterial igbese ni lati ṣe idiwọ biosynthesis ti peptidoglycan ti ogiri sẹẹli.Bi o ṣe jẹ afọwọṣe igbekale ti D-alanine, D-cycloserine le ṣe idiwọ awọn iṣẹ ṣiṣe ti alanine racemase ati D-alanyl-D-alanine synthetase, eyiti o jẹ awọn enzymu pataki meji ni iṣelọpọ peptidoglycan.D-cycloserine ṣe afihan iṣẹ ṣiṣe idilọwọ alailagbara lodi si iko-ara Mycobacterium eyiti o jẹ 1/10 si 1/20 nikan ti streptomycin.Anfani ti ọja naa ni pe o munadoko lori awọn igara iko-ara Mycobacterium ti ko ni oogun ati pe o kere julọ lati fa idamu oogun.Ọja naa le ṣee lo pẹlu awọn oogun egboogi-ikọ-ara miiran ni itọju ti iko ti o fa nipasẹ iko-ara Mycobacterium ti ko ni oogun.
Cycloserine jẹ oogun atako-ila-keji.O le ṣe idiwọ idagba ti iko-ara Mycobacterium, ṣugbọn ipa naa jẹ alailagbara diẹ sii ju ti awọn oogun laini akọkọ.Ipa rẹ ninu itọju iko jẹ kekere diẹ.Lo oogun naa nikan le ṣe agbejade resistance oogun, ṣugbọn resistance naa waye laiyara ni akawe pẹlu ti awọn oogun egboogi-ikọ-ara miiran.Ko si atako-agbelebu laarin cycloserine ati awọn oogun egboogi-ikọ-ara miiran.Ilana ti igbese antibacterial rẹ ni lati ṣe idiwọ iṣelọpọ ti peptidoglycan ti ogiri sẹẹli kokoro-arun, ti nfa abawọn ninu faaji ogiri sẹẹli.Ẹya ipilẹ akọkọ ti ogiri sẹẹli kokoro-arun jẹ peptidoglycan, eyiti o jẹ ti N-acetylglucosamine (GNAc) ati N-acetylmuramic acid (MNAc).N-acetylmuramic acid jẹ asopọ pẹlu pentapeptide ati so N-acetylglucosamine so pọ ni ọna ti o tun ṣe ati yiyan.Ibiyi ti cytoplasmic peptidoglycan ṣaaju le jẹ idilọwọ nipasẹ cycloserine, bi igbehin le ṣe idiwọ racemase ati synthetase ti D-Alanine, ati nitorinaa ṣe idiwọ dida N-acetylmuramic acid.
D-Cycloserine le ṣee gba nipasẹ ilana bakteria tabi nipasẹ iṣelọpọ taara.Awọn kokoro arun ti a lo ninu bakteria jẹ Actinomyces laven-dulae.Awọn alabọde bakteria oriširiši dextrin, dextrose, sitashi, soybean lulú, iwukara lulú, ammonium sulfate, ammonium iyọ, kalisiomu carbonate, soda kiloraidi, magnẹsia sulfate ati soybean epo.Ninu ilana iṣelọpọ, D-Cycloserine ni a gba lati β-Aminooxy alanine ethyl ester hydrochloride nipasẹ ifaseyin pẹlu potasiomu hydroxide ni iṣesi cyclization.
